Can SPG302 Rebuild My Brain? | Schizophrenia in 2025

Imagine a future where schizophrenia isn't just managed, but potentially healed. That's what Stephen and his dad, Steve, explore in this episode of Surviving Schizophrenia. They dive deep into the world of regenerative brain therapy and a revolutionary medication called SPG302, currently in phase two clinical trials in Australia.
Stephen opens up about his personal journey with schizophrenia, a journey that drastically altered his life 13 years ago. He went from being a straight-A student to struggling with basic math and focus after his illness began. He shares the challenges of living with debilitating negative symptoms like social withdrawal, lack of concentration, and cognitive difficulties that make everyday life, including holding a job, incredibly tough.
Steve, Stephen's dedicated father and support person, brings a unique perspective. He discusses regenerative therapy and how connections (synapses) in the brain can be damaged by schizophrenia. SPG302 aims to repair those broken connections, potentially restoring cognitive function and improving quality of life.
Stephen paints a vivid picture of his hopes for the future with this therapy. He dreams of regaining his cognitive abilities, securing a job, and being more productive. He even envisions a life where he can reduce his medication and overcome the challenges of misophonia, a condition that makes him overly sensitive to certain sounds.
This video isn't just about a new medication; it's about hope and the potential for a brighter future for those living with schizophrenia. Stephen and Steve's genuine optimism is truly inspiring.
Want to learn more about this groundbreaking research? We've included links in the description to articles about SPG302 and regenerative therapy for schizophrenia.
Join the Surviving Schizophrenia community! Subscribe to Stephen’s channel for more personal stories, informative discussions, and the latest updates on schizophrenia treatments.
We want to hear from you! Share your thoughts on regenerative therapy in the comments below. What are your hopes for the future of schizophrenia treatment?
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PSYCHIATRIC TIMES: www.psychiatri...
Synaptic Regenerative Therapy
Synaptic Regenerative Therapy, using drugs like SPG302, represents a novel approach to treating schizophrenia by focusing on regenerating lost synapses in the brain. This is a significant departure from current antipsychotic medications, which primarily target dopamine receptors to manage symptoms, but often fall short in addressing negative and cognitive symptoms, and may not work for all patients.
SPG302 specifically targets glutamatergic synapses, the primary excitatory connections between neurons, which are believed to be diminished in individuals with schizophrenia. By restoring these crucial communication pathways, SPG302 aims to reverse a core anatomical deficit thought to underlie the various symptom domains of schizophrenia, including positive symptoms (hallucinations, delusions), negative symptoms (social withdrawal, apathy), and cognitive impairments (memory and attention problems).
As of October 31, 2024, SPG302 is undergoing Phase 2 clinical trials in Australia to evaluate its safety, efficacy, tolerability, and pharmacodynamics in individuals diagnosed with schizophrenia.
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[@richardpilkington]

The excitement and happiness on your face makes me smile Stephen. I’m in Australia and had not heard about this treatment. Look forward to seeing how it develops. All the best to you and your family 🙂

[@lindaarkert9919]

Wow, this is so exciting Stephen. My son has schizophrenia, and the possibilities of this provides so much hope. Thank you both.

[@lch5524]

Hi from Australia 👋. I hope this Australian research has positive outcomes for schizophrenia and also hope it can have results with Alzheimer’s as l lost my mother to this horrible disease. Thanks Stephen for your content and positivity.

[@matthiasknaak8527]

That is wonderful news. We wish you all the strength and dilligence to be able to receive this treatment. It will be wonderful 😊. Happy New Year

[@vickismith3290]

I hope this all comes to fruition. I see it helping so many people. Keep us posted.

[@BeckyKay-m7v]

Wow! Thanks for the wonderful information! That would certainly be life-changing for my son!! Before he fell ill, he loves sports, being active, people & staying busy. Now there are days where he doesn't want to get out of his bed, shower, or eat. If that medication proves positive in people with schizophrenia, it would sure give some hope for the future!! Thanks for the update & link!!

[@catherinej2020]

I'm looking for ways to improve my schizoaffective disorder. To be able to be "my old self" would be great. Thanks for this information! It's definitely food for thought.

[@loricole1299]

That is amazing news! Praying for a "re-imagined" brain for Stephen!

[@es4242]

Exciting news, so happy about the progress in research.

[@dardan9218]

Let's hope! Thanks Stephen and dad, wish you all health and well-being : )

[@Dark89Avenger]

Hello ! First I wanna say, that as a clinical psychologist, I am so glad to hear that there is work being done on brain regenerative medication. This is going to be game changer, no, not even that - it is going to be a revolution ! Also, sadly, cognitive discfunction can be found in everyone, who is suffering from schizophrenia. In some people to a lesser extend, but it is still there. So if this medication actually works, it will help everyone, and not only people who have schizophrenia, but also many other with psychiatric and neurological conditions.

[@SurvivingSchizophrenia]

Thank you very much for your comment! I totally agree. Have a happy and healthy rest of your day! Thank you for watching and sharing!

[@Dark89Avenger]

@SurvivingSchizophrenia Thanks and take care!

[@educating3281]

Thank you for the update and new hope!

[@SurvivingSchizophrenia]

You are very welcome!

[@NavigatingthePeriphery]

This is great! I would love to have improved cognitive abilities. I feel like my schizoaffective disorder mixed type has robbed a lot from me. There is hope! 🙏

[@FeiLong-u5z]

Wow, exciting stuff !! Look your a really smart guy and have great insight to not only your illness but to yourself as a person. I can't lie this news is exciting. It's exciting but before it's completely a success it can be important to embrace your illness. I know that's completely impossible at times but to accept and embrace is empowering ( before this new treatment is a complete success ). Your special Stephen. You have a special way of receiving the world. Is that a hindrance or a gift aswell? I actually see you as a majorly successful guy. I feel like your getting down about your situation and your medication. That's just a phase. Be one with the madness. Thanks for the video. Your dad seems like nice guy ❤

[@IlikeTurtles316]

It's really promising what the future holds in terms of treatment. I hope the clinical trials go well! Thanks very much for sharing with us.

[@SurvivingSchizophrenia]

You are very welcome!

[@Yahoo.266]

It’s so strange how certain things people do would disturbe you. My brother who has had schizophrenia for over 3 decades is totally the opposite. He’s the one who is a messy eater, and just careless with all his ways with no care in the world. Unfortunately, he chooses drugs 😢. Very hard situation for my parents. He’s on the strongest monthly shot & still goes through hearing voices. 😢. All the best with your bright future. 🥰

[@SchizoKitzo]

This was a fantastic deep dive into the implications of a treatment like this! SPG302 sounds super promising, and I like how you guys didn’t sugarcoat at all here and just had a candid conversation about a treatment that might just change it all. I’m hopeful for myself as well. Thanks for this video!

[@SurvivingSchizophrenia]

Thank you so very much @SchizoKitzo ! I really appreciate that!

[@jessicarettally6534]

Hi Stephen! Hope everyone is safe, watching the fires on the news and praying for you all❤

[@SurvivingSchizophrenia]

We are safe, thank you so much for your prayers!

[@jessicarettally6534]

@SurvivingSchizophrenia So glad to hear Stephen!

[@me-cfs-strategiesforhealing]

This is absolutely the way to go Stephen, trying to rebuild your brain’s health and function from the ground up. Have you thought of hyberbaric oxygen therapy? It can help proufoundly with neurological problems, even traumatic brain injury and PTSD. Brain scans before and after course of treatment show brain regeneration. Perhaps something to try while you wait for this drug. You and your Dad are a great team.

[@SurvivingSchizophrenia]

I have not tried that, but I will look into it! Thank you and have a happy and healthy rest of your day!

[@lamoureuxtransi]

You should test for Bartonella Henselae too. I got positive in 2021 and it’s highly linked to Schizophrenia. I’m treating it and I’m beginning to feel a little better.

[@isaaclarian1827]

Thank you 🙏🙏🙏☺️

[@SurvivingSchizophrenia]

You're welcome!

[@Callie-m1x]

Im surprised to have even made it this far

[@Lisa_RNHealthHub]

Awesome news!

[@TakeGoodCare90]

Thank you for introducing this to your audience. I was not aware of it. I am in the process of switching to Cobenfy. What an exciting, promising year this has been for everyone on the schizophrenia spectrum. Two questions: 1) Is this medication only being tried on people with detectable brain damage, or is it more generally being given to anyone with a diagnosis? My MRI is normal but I have the illness, and I'm totally naive as to how medicine would target/allocate the drug's use, as I imagine synaptic/connective loss wouldn't really show up on an MRI. I'm guessing they'd give it to anyone with the diagnosis under the assumption that we're all suffering from this loss. Is that right? 2) The internet claims this medicine also restores motor connections . . . Does that imply it could be a partial treatment for EPS/TD?

[@Ekhlaas9777]

According to what I read on the account of the producing company in x This medicine works to renew brain cells and treat the following diseases: schizophrenia Alzheimer's ALS FTD

[@Christian-qu9ml]

Wow! 😮

[@somematters5713]

Hi You put very excellent videos Very informative Thank you for that. I have a question: What was the first symptom that alarmed you that there is something not going right. And did you experience day dreaming before illness. Thank you

[@jessicarettally6534]

Excellent news🎉

[@Callie-m1x]

It hurts that i cant get better and only worse😢

[@leinad5243]

How about gardening? In the spring a garden store?

[@cevatziya5387]

Hello, will this drug from Austria completely cure schizophrenia? And should it be taken constantly or what? Thank you

[@أمةالله-م7ذ]

مهتمة

[@MaddyPup19450]

How is the drug thought to work?

[@SurvivingSchizophrenia]

It helps the synapses reconnect in the brain.

[@wizardlyrhino2824]

So is this an actual cure for schizophrenia? Or is it another pill I have to take the rest of my life? Very curious.

[@lschwaier]

I believe my mom got schizophrenia because she smoked since she was 12.. i got schizophrenia from smoking cannabis at 18 and weekend drinking. and perhaps other things like the 90s-2000s food diet. You arent eating sugar are ya? Carnivore diet helps, lift weights. Dude i can tell you arent that bad man, Workout now while you are young.

[@Callie-m1x]

Still not doing well..

[@SurvivingSchizophrenia]

I’m sorry to hear that.

[@leinad5243]

Have you had a brain scan?

[@SurvivingSchizophrenia]

Yes I have had multiple brain scans.

[@SandraDoell-w5d]

🌌🙏🌌🙏🌌🙏🌌🙏🌌xo's

[@constantinhaller4391]

Ur not up to Date my Friend. They already have such a med. Out in 2026 called evenanide

[@BeckyKay-m7v]

Stephen, i sure hope you and your family are safe from the wild fires!!! Can u plz post a little something or just respond to my comment?? Prayers!!

[@SurvivingSchizophrenia]

My family and I are ok. Thank you so much for your kind comment and prayers.

[@BeckyKay-m7v]

@SurvivingSchizophrenia im sooo glad!! These fires are sooo scary!! Thanks for your response!

[@나나나-r3p]

Eat phosphatidylserine Good

[@leinad5243]

Is this a pill?

[@sandy4230]

Pray 🙏 Jesus will heal you rebuke this illness of the brain. Let Jesus fight for you ❤He can make everything new again.

[@kitandsons173]

My son can not deal with any plate scraping sounds, straws or forks hitting teeth. If he is stressed. We order pizza on paper plates.