Coagulation Cascade || USMLE

[@chrischen2256]

My silly way to remember the relationships: PTT - play table tennis (you play table tennis inside = intrinsic). Its heparIN PT - play tennis (you play tennis outside = extrinsic) By deduction warfarin is here.

[@aroushhashir960]

Chris Chen Remember War is Extrinsic .... we don't go to war intrinsically...

[@atllantiss]

or I (Intrinsic) comes after H (Heparin)in the alphabet

[@dulcetoralba1868]

Amazing thank you

[@Jeremykade]

Thank you!!

[@loving60s]

But warfarIN could work with INtrinsic too... so not ideal to solely rely on this mnemonic

[@sarahjanesalvan8202]

You can remember what drug is for which pathway by thinking of the alphabet. H for heparin is followed by I for intrinsic, W for warfarin is followed by X for eXtrinsic. (Heparin=Intrinsic; Warfarin=eXtrinsic). I just came up with this after watching your video, thanks so much!

[@MdMazidulHaque]

tnx

[@drrahul5839]

good one thank you

[@HARU.7243]

thank u

[@reachtt]

Great thinking. Thx

[@shivashankargoud422]

Thanks

[@dashcamera_daily]

Missing factors Factor 1 = Fibrinogen Factor 3 = thromboplastin Factor 4 = Calcium Factor 13 = Fibrin stabilizing factor

[@mscrawford87]

I always remember that PTT is affected by Heparin, because PTT has two "ts" next to each other (like tt, or TT) which resemble the capital letter "H" although it depends on your font/handwriting. This might just work for my brain only, but hopefully it helps others! :)

[@Doctor_Sin_Tabu]

Cool!

[@amitanandda]

Nice way of remembering......

[@yankzaddict02]

another good way to remember it is PT = playing tennis (outdoors -> extrinsic) and PTT = playing table tennis (indoors -> intrinsic)

[@Lechu1982]

@@yankzaddict02 this is gold! thank you

[@witwatersrand2486]

warfarin will affect both extrinsic pathway and common pathway...remember Vit K dependent factors 2,7,9 and 10

[@rickkarsan4491]

and protein c. you are hypercoagulable on initiating warfarin.

[@ksuar8996]

And intrinsic?

[@Baldwinthefourth-1176]

@@rickkarsan4491 also protein S :)

[@kishahimaya6043]

I remember heparin=PTT and warfarin-PT by remembering to make 10 letters for both so... it goes like this H E P A R I N ( P T T ) = 10 letters W A R F A R I N ( P T ) = 10 letters

[@annalovel5475]

And he said there's really no good way to remember this. Your memory aid is great! Thank you!!

[@pragyadwivedi2204]

Write a capital I ( the one with bars on the either end of the line) and turn it 90 degrees; it becomes H. I for intrinsic; and H for Heparin.

[@careplushospital9070]

HINT : HEPARIN INTRINSIC PATHWAY WEPT: WARFARIN EXTRINSIC PATHWAY HOPE THIS CAN HELP YOU REMEMBER .

[@daaxab]

Lol I expected that 'HOPE' was also going to be a mnemonic. 😅😂

[@marissacopasweaver2213]

I really like this mnemonic, but my OCD struggles with the final picture because the last step of the common pathway is Fibrinogen (I) to Fibrin (Ia). So I add "1" to the bottom of the common pathway and said that it stands for "One common math problem (pathway)".

[@xoxomikimouse]

I remember warfarin with extrinsic b/c "To WAR with your EX" WAR= warfarin EX= extrinsic

[@raphaelmalpica401]

Thank God for this video!!! If you go to page 383 of the Hematology and Oncology chapter in the First Aid for USMLE 2016 and look at the coagulation cascade! Thanks to this video it made it way much easier to deal with. Gracias!

[@toherstudies]

My professor had this mnemonic which actually helped bc I love Brad Pitt haha (brad) PiTT -- intrinsic pathway, PTT (I love) PeTs -- extrinsic pathway, PT Hope that helps!

[@kaitlynestes9942]

a great way to remember is we measure INR aka PT for warfarin -> warfarin blocks formation of VitK dep factors --> 2 7 9 and 10 --> 7 has the shortest half life and degrades first = easy way to check warfarin levels bc its the first factor to go

[@christophertatman7772]

E (for extrinsic) put on it's side makes a W (for warfarin).

[@spideylover4105]

two times five that's 10, minus 1 that's 9 quick maffs. ya dun know.

[@af7318]

you should really teach this stuff part time. your really good at explaining material

[@MrTiwarygunda]

(warfarin)War outside-extrinsic (Heparin )Hepatic inside body -intrinsic

[@dr.poornaprajna]

PT (physical education teacher) is always OUTside. He is FAST and always ready for the WAR! PT → OUT (extrinsic pathway) → FAST (fast reaction) → WAR (warfarin)

[@xlovelykisses21x]

I like to remember that in WAR(farin) you need a PT (physical therapist)

[@mayuribirajdar3215]

Heparin is already present in our physiological system in mast cells but inactive anticoagulant ,,,so it's present inside= Intrinsic and oppsite to it warfarin = extrensic

[@zakariyyagardee8934]

Thank you so much. Please consider making a video on Anticoagulants as a follow up to this.

[@oust4260]

This was just shared to me: PeT: PT is for Extrinsic PiTT: PTT is for intrinsic

[@melaninmonroe007]

WEPT: Warfarin Extrinsic PT

[@oyedotunodunayo406]

Heparin = Help comes from inside (Intrinsic) Warfarin = War comes from outside (Extrinsic)

[@金子裕介-g7n]

PT is influenced by coagulation system, APTT is not. An exception is vWD.

[@medicineislifeee]

We've gotta get your channel more subscribers!!

[@DirtyMedicine]

I agree!! Please share :) Thanks

[@Khewarat]

Dr. Sattar has a great pnemonic. on the floor you refer to Heparin as HEP. 3 letters. like PTT

[@DirtyMedicine]

ive never heard it referred to as Hep, but yeah that definitely works if you can envision/hear it like that in your brain

[@IrshadKhan-om6sh]

I've a question. As warfarin blocks vit K dependent factors like 2,7,9 and 10, As factor 9 is part of the intrinsic pathway so why does PTT not affected by warfarin?

[@TaniaAkter-pn4px]

This video is a a life saviour & comment section is another saviour 😂

[@amitpower9455]

thanks from delhi and keep up the great work....I finally cud cram it up. I remember like this WET your PET for 7SEX ( W=WARFARIN EX =EXTRINSIC 7=FACTOR7 IN EXTRINSIC PATHWAY ) Dr Amit

[@shahadm7875]

خططططييييررررر ، مبدع والله ✨✨✨

[@atllantiss]

or I (Intrinsic) comes after H (Heparin)in the alphabet

[@Enolaa19]

This is abso-freaking-lutely amazing ❤

[@drzainabtahir3554]

Superb.... I've always struggled with this topic.... Thank u so so much❤

[@aroushhashir960]

Remember War is Extrinsic .... we don't go to war intrinsically...

[@ARHSDA]

But then there is the civil war... lol

[@EneAbbah]

😂😂

[@admorgz]

Nice 👍

[@surdigital9851]

nice,! I recomend that after watching the video get a pen, a paper and try to do it on your own

[@tdawgt5866]

How can you remember a nemonic that makes no sense but not the actual coagulation cascade information!

[@stewartmaclean527]

Is there any chance you can do a video on cytokines? It would be great to get an explanation and some mnemonics for which cytokines are used in which responses. Thanks!

[@DirtyMedicine]

I have one.. search the channel :)

[@stewartmaclean527]

Thank you so much! Can't believe I didn't see that initially @@DirtyMedicine

[@bethiefish5915]

Play tennis outside for PT for extrinsic and play table tennis inside for PTT for intrinsic ;)

[@hennaalexander6778]

Please keep making more video.. you are a lifesaver😍

[@DrA902]

Note : calcium used in most of step except first two step ( calcium = factor 4 IV) thx❤

[@seacebedo]

I'm gonna use this. Thanks!! But what about factors I, III, and XIII? I'm gonna have to just memorize those, i guess. This makes it easier though. Also worth mentioning factor IV, which is present all over the place in the whole cascade.

[@iram1234542]

OMG this video is great, so helpful!!! Keep them coming.

[@davidpolito539]

pneumonic or mnemonic?

[@biloz2988]

I hv to tell you that this video confuses most of clinicians who memorized the cascade the way it is. 1st: memorize the cascade as it is with Roman numerals 2nd: remember that 2+7->9->10 that’s Warfarin which is given externally (PO) and thus affect the extrinsic pathway more (PT) 3rd: Heparin is given IV, that’s intrinsic and affects F XII -> F XI -> F IX 4th: heparin works faster (IV), but warfarin works way slower (PO) Pls remember that in clinical practice we rarely use either and now we use other oral inhibitors (NOACS) and SQ inhibitors (LMWH etc), which were not discussed here at all. In summary this video is way confusing and way way way out of date. Pls replace it.

[@ast1848]

Really having trouble memorizing glycogen and lysosomal diseases, Please share mnemonics for those. Thanks

[@DirtyMedicine]

I have a video for Lysosomal Storage Diseases already. Link: kzbin.info/www/bejne/babHhnpugNCBlac

[@ast1848]

Alright, a few pathway disorder (ie. galatosemia) mnemonics would be nice

[@enochbrown8178]

Sometimes, it's just better to rote memorize things. IMO

[@thitsarmin]

Why he didn’t mention factor XIII ?

[@CaseyLindstrand]

Very good video! Thank you.

[@JeremyJonathan-c9r]

You made my day. Thank you!

[@adilkhalid3736]

HePARin = PARty INside, WARFARin = warfare outside

[@AhsanKhan-wo2ql]

Summary from 6:05

[@39.shaheenkhatooncnmc70]

Bless you man❤

[@s.a4243]

Heparin intrinsic because administred IN the body (s/c or i/v), warfarin extrinsic because administred from OUTSIDE the body (oral) ;)

[@raphaelmalpica401]

H is HIGH UP there for Heparin.

[@itzBarto]

This is genius!! Thank you soo much! :))

[@suomynonaanonymous]

Did you delete some videos ?!

[@nelsongonzalez4427]

When I'm learning coagulation cascade I'm "IN Hell" and I need "EXtra WAter". Heparin for intrinsic and Warfarin for extrinsic

[@ashleynaylor8609]

This video is awesome! Thank you!

[@tonitonichoppabeingthefutu627]

i learned a lot! thank you

[@emdarich]

You are awesome, thank you

[@mohanaddablouk]

You are a genius

[@josephknight1471]

Thank you, nicely done.

[@NARESHVIDEOS]

Thank you soo much sir😊

[@jasontan6013]

holy damn. this is amazing

[@gautamdubey6526]

Awesome !

[@kamarkrayem1646]

just awesome

[@natasha1394]

You are the best

[@Palamaopa]

You saved my life

[@samg290]

pEt pItt bull pt - Extrinsic ptt - Intrinsic

[@HARU.7243]

most helpful...

[@jmorrison10]

thank you

[@bahiachibi895]

amazing

[@YuiYui-uq2nu]

Mannn... I love 10 dollars rules❤

[@thangzawna]

I like the video even before watching it. I trust you lol

[@mariamaestevens]

brilliant!

[@mychocochip]

Brilliant

[@arunabhmishra2265]

This is the bestttttttttttt

[@shagulhamad1948]

genious

[@nedakhan6959]

Great Thank uuuuuuu

[@DocLiabrary2k17]

❤❤

[@joeyelkhoury4632]

You rock!

[@Cass_i]

Ahhh the math lost me 😭

[@Notimportantatall12]

Love you ❤

[@sadianaseem568]

cool!

[@supreetraina2319]

WEPT at war W- Warfarin E- extrinsic PT affected

[@edenleave2054]

Hip Brad Pitt - heparin ptt

[@oraena5526]

Tysm🥹🥹🥹🥹🥹

[@makeitaleapyear6062]

smart !

[@stassji5041]

Ohmba balaya 😏

[@beratakn6007]

omg !

[@VIPK37]

i love u

[@casseycedricdominguez113]

War with your EX so you wePT

[@mg9935]

i love you

[@sarmadatravels]

soo silly...simple things made complex

[@oyshisarker2690]

thank you