DON'T Take Resveratrol Until You Watch This Video | 34 - Longevity Science #6

[@Tron-Jockey]

Matt Kaeberlein and Brad Stanfield, the best, most unbiased "true" medical professionals providing information on the Internet.

[@theresefarrugia1257]

But all they do is hack at others. They don't actually do anything but troll Sinclair. Where is Kaeberlein's lab? His funding? What has he published lately? Or ever really....it's ah wait...... Non existent! His cherry picking of research against resevertrol just projects his envy and shows his blaring cognitive bias. He is a troll who has no content unless he " word salads"abput david sinclair. No one is watching unless he blubs about david. anyone who All his suggestions of bad science is just his sour grapes. He is a troll and a failed academic. Yawn. Optisoan is mat kaeberlein and a lap top. Who just whines and whines and tantrums about more talented peers. Good luck with that

[@elijahmlller]

Brad stanfield is soo freaking CUTE!!!!!!

[@danrobinson9035]

Great presentation Matt !

[@raymondbrowning762]

Also many thanks for this video, I am afraid that I had always mistrusted D.S. and this really damages Harvard's reputation.

[@danmarquez3971]

Super interesting! Your knowledge and experience is very impressive! Thank you for the great video!

[@Jessica-kk1cz]

Naturally this egomaniac hearts the comment complimenting his “impressive knowledge”. This guy is just another Stanfield KZbin wannabe.

[@danmarquez3971]

@@Jessica-kk1cz ???

[@adjusted-bunny]

All that red wine.....in vain!

[@ShazWag]

🤣

[@jellybeanvinkler4878]

🍷🥴

[@EkilRevolution]

actually the ethanol might be modestly beneficial . search ethanol mouse lifespan , it cause very small increase

[@willkat64]

Given the cumulative research evidence in academia and in GSK showing that resveratrol does not activate sirtuins nor increase lifespan, Nature should retract the 2003 yeast and 2006 mice papers of the Sinclair lab, and Sinclair should not be allowed to continue tarnishing the image of Harvard Medical School and the gerontology field.

[@diamond_s]

Multiple labs have shown sirtuin activation. Resveratrol was strongest sirtuin activator and is cheap nonpatentable. Gsk was angry cause they thought sinclair would give them patentable molecules that were better or half as good.

[@Christian-cu8eo]

Many thanks. You’ve put so much effort into this and I really appreciate it. Any chance that you do a similar clarification regarding NMN? I heard so many different view points, including from Dr Brad S. and Physionic. I still have questions

[@raymondbrowning762]

Matt: This may be a premature question(s). We have multiple (now at least 12) hallmarks of aging. We have multiple intervention's, exercise, lifestyle, multiple drugs, etc. that individually contribute positively to health and life span. Is it possible to understand the cumulative effect? Is there a summation, are many of the effects overlapping, is there a key component that is missing? Each of the 12 hallmarks needs to be addressed, if one is missing you still have a problem, where are we on that?

[@olgalyubechanskaya7427]

Brain.

[@theancientsancients1769]

You are correct. The least we can do is to address

[@peterz53]

Thanks. Appreciate the deconstruction and level of detail. I took ResV for years, although at a low dose. Eventually just made sure I got a lot of polyphenols/flavonoids along with a good diet and exercise. More I learn, exercise has many benefits, not the least is maintaining immune function which is vitally important.

[@CraigHocker]

13:07 I found the Vitamin E data showed a significant positive effect. That seems to counter what had been said about supplementing with Vitamin E showed a slight increase in mortality in humans like Vitamin A supplementation.

[@lucycooper55]

I’ve been buying NMN and Resveratrol by the pounds. Thank you putting things into perspective for us 🥲

[@Live-Forever-Club]

What got me was the impact of the initial incorrect finding and the researchers' refusal to retract the paper. Wasted time (and grant money) by so many other researchers trying to replicate it Reduced confidence in the entire field of longevity research Withdrawal of big pharma from investments People buying supplements (and drinking red wine) when they could have tried something else These are serious consequences!

[@newyorkskier]

I don't think lifespan extension, but if it has other health benefits that will be good. If you take omega3 fatty acids, I don't think it increases lifespan but it has many health benefits.

[@Нфт-ц8и]

Thank you for your work ❤

[@diamond_s]

The data does back it up 92% prevention of epigenetic aging in the heart even more than CRs 90%. Similar to CR but stronger. Also shown fully rejuvenating near senescent human cells and vastly restoring their telomeres..

[@xuxiaohong888]

Resveratrol works great 👍 in my 6 years of experience taking resveratrol daily

[@fishnski9211]

I've got 2 bottles left...I'll finish them in rotation with cq10 and Astaxanthin and no more after..I had quit Res maybe 10 or more years ago when the first negative studies came out but was suckered back in..

[@gregsLyrics]

Resveratrol and its analogues such as pterostilbene give me extreme arrhythmia (reasons unknown). Because I have been prevented from taking them as a health supplement, I feel like a very lucky person after digesting this brilliant vid. Thank you Matt for all that you do to inform those will listen and heed your wisdom.

[@ats89117]

The most debunked longevity molecule in history, and also the most profitable. Yikes!

[@bangyabangyamj]

Thank you for sharing your knowledge and experience! I have a different focus to ask. You mentioned at the beginning of the introduction that “Resveratrol is found in various plants, including the skins of grapes, blueberries, raspberries, mulberries, and peanuts.” Many researchers, it seems including you, I never seen mention of peanut sprouts. Peanut sprouts contain 50 to 100 times more resveratrol than red wine, and the resveratrol content increases about 90 times as peanuts germinate. I have been trying to find an answer to why peanut sprouts are frequently excluded from discussions on resveratrol sources. I would love to hear your thoughts as it is very important. I am not a scientist, but I am eager to learn and obtain accurate information from experts. Thank you!

[@Drez1st]

Everyone saying it works for them: Is this scientifically backed by data? Did you test - supplement - re test, changing absolutely nothing else in your regime? Its so hard to quantity what aspects of one's lifestyle is contributing without doing experiments and testing in a controlled manner. I suspect everyone taking ResV exercises, eats healthy and takes other supps too.

[@chuckding5590]

They may be selling supplements or may be experiencing a placebo effect.

[@lumanliu8457]

Why is there only one data point for rapamycin? Are all the other data points inside the box?

[@in2caffeine]

Resveratrol and Co10 has helped me with iron overload. Excessive iron drives again.

[@xuxiaohong888]

My own experience with Resveratrol is outstanding. Keep it up 👍

[@chuckding5590]

Selling supplements?

[@7TheWhiteWolf]

It’s also an Endocrine Disruptor and lowers DHEA, DHEA-S and Androdenistione, and it prevent the detoxification of Estrogen in the liver. So not does it do nothing for aging, but it also lowers and messes your hormones because of it’s estrogenic activity.

[@smytharmstrong8543]

I was shocked by your graph, which supposedly showed that vitamin E was at the top of the list along with rapamycin for promoting lifespan. Vitamin E is cheap and readily available -- why is no one talking about vitamin E (type, amount and timing) as a longevity strategy? What am I missing? Could you please address vitamin E in one of your KZbin talks?

[@waisssss123]

Thank you sir for exposing the truth.

[@ernstfehr5925]

great video, very informative

[@rainerlanglotz3134]

No doubt about your conclusion on resveratrols failure to increase Livespan or even Healthspan. YET I believe the molecule can be useful because it turned out recently to be an Antagonist of the Arylhydrocarbonreceptor (AhR). Therefore Resvertrol may be a save antidote for TCDD-like toxic molecules that get more and more ubiquitious. Anecdotally I can testify there is a distinctly positive effect on brain fog.

[@xuxiaohong888]

I have taken Resveratrol for 6 years. It has been great 😊 so far

[@chuckding5590]

A great expense? In what way great? Selling supplements?

[@chris-lk4ml]

Ive drank some bottles of red wine because of resveratrol. But I was struggeling with the alc. Instead I tried reading the papers myself. It did cost me some years to get into the field, but at least I am. So in my case RES did something good but it wasn't about the lifespan thing.

[@mjiverson9105]

Ur the best💪

[@Нфт-ц8и]

It was a scam from the very beginning.

[@diamond_s]

Calorie restriction prevents 90% of epigenetic aging in the heart. Resveratrol has similar epigenetic aging effects but it prevents 92% of aging related epigenetic changes even more than CR.

[@chuckding5590]

Selling supplements perchance?

[@osmanyaldiz1983]

I have an atm heyerozygous mutation and all I care about is whether resveratrol will increase the activity of the half-produced atm protein and whether this is good for me.

[@밍하]

what about vinia piceid reveratrol? it claims it is different from normal trans resveratrol

[@charlesgreen7408]

Thank you for your hard work 🤗

[@diamond_s]

So the test on yeast cells, the test on human cells, the test on mice with mitochondrial disfunction, the test on senescent accelerated mice, the data on fasting mice, the data on obese mice, the data on shorter lived mouse strain is all wrong? As it showed rejuvenation and life extension in all of these. Keep in mind big pharma has big incentive to introduce fud just like smoking companies did. Even nasa was looking into using resveratrol given it diminishes muscle wasting upon inactivity. Multiple labs have shown sirtuin activation of resveratrol and similar molecule pterostilbene.

[@lumanliu8457]

Can you please share some of those research paper links? Would be nice to verify. Thanks.

[@diamond_s]

It is difficult to share links on youtube. Ive tried several times and youtube seems to remove replies in videos Ive tried sharing links. I can give you some references youtuber Michael Lustgarten covers the fasting mice resveratrol effects in a video, life extension magazine had an article regards the research showing life extension in both aging accelerated mice and in normal aging but shorter lived mouse strains.

[@diamond_s]

Regards Nasa check out the cnn article An antioxidant in red wine might power astronauts on Mars, study says

[@abdmus1785]

Can you make videos on other molecules which also promoted by Sinclair such as nmn, quercetin and spermidine. Thanks

[@RobertNaik]

If it’s on the Joe rogan show it can’t be good. Sinclair with this and graham hancock with fake archeology.

[@diamond_s]

Regards the artifact of fluorescent, iirc, it was found a similar molecule to the dye exists in cells confering same ability to activate sirt1 in vivo. Resveratrol also lengthened normal aging shorter lived mice strains and fasting mice. And ITP is questionable in my book they used synthetic rather than natural astaxanthin and in megadose, after that i question itp.

[@zack_120]

Powerful data 👍

[@mark-c802]

is resveratrol in food or drink truly the same as from a test tube?...i don't care about the longevity benefits but it seems the various polyphenols, tannins, amounts of vitamins and minerals are worthwhile in their natural form whether its red wine or another food

[@ShazWag]

Thanks for this. Do you have a link to the studies you've mentioned, please? As for Sinclair, yes, he's milking it! 💊🤑

[@optispan]

Glad you enjoyed it! Show notes with links to studies will be published shortly at optispan.life/podcast. - Tara

[@megaintegrator]

yes, this D.S seems big oil and snakes seller, I stopped to buy NMN and Resveratrol 1 year ago, think again, if these are sao good, why they emphasize the power of sleep so much? why we need these pills then if sleep is doing all things?

[@7TheWhiteWolf]

GSK really should go after Sinclair legally, if I were them, I would want my 720 million back. Sinclair doesn’t deserve it for all of the lies he’s spouted over all these years.

[@noahlovotti7722]

​@@7TheWhiteWolfput that 720 million towards actual longevity research.

[@Normi19]

Similar stories exist in the battery technology space within academia. Self-promotion and financial incentives by questionable professors drive this behavior. I've seen it first-hand.

[@vanguard7674]

Does David Sinclair hate you? :(

[@noahlovotti7722]

This is why we should work away from sinclair and supplements. We need to move forward and accelerate efforts for longevity.

[@jordistulen4565]

Matt sounds like a guy after 10 years we find out he filled he's pocket behind our backs, hidden agendas everywhere

[@cactuscanine3531]

This video should not have influenced anyone. You should have figured out long ago that Resveratrol was worthless.

[@diamond_s]

If you listen to big pharma. While nasa considers its use. And research shows it lengthens telomeres and rejuvenates human cells.

[@presence5426]

You should have told everyone long ago.

[@ananiadoesgaming8808]

What’s your issue with the great Dr. Sinclair…. You can’t be that ignorant and extremely negative… shame on you

[@MixtrisUFOimages]

great? i wouldnt go that far. for a start he's a louse when it comes to what he's done with NMN. though i dont take it as i think its useless; but to be fair sinclair looks way younger than Matt so there's something he's doing right given that he's also is a year older than matt . sinclair says his detractors do not take RES with fat for absorption. i didnt hear info here about that. I really dont know either way as i'm no scientist. but i do know there are experiments done in favour of resveratrol with regards to the dosing. too much is negative and a little amount show some benefits that matt is not mentioning here so i dont know.

[@chuckding5590]

Sell8ng a supplement per chance?

[@noahlovotti7722]

We will reverse aging better without him.

[@Kain17298]

Tous ceux qui critiquent David Sinclair font vieux pour leur âge, je ne sais pas s'ils sont de bons conseils.