B12 Deficiency and Neurological Disease [Explained by Neurologist]

B12 deficiency is potentially dangerous and can cause neurological diseases such as peripheral neuropathy, subacute combined degeneration of the spinal cord, optic neuropathy, and dementia. This video reviews absorption of B12, common causes of deficiency, laboratory testing, and abnormal imaging findings.
Selected Sources:
Neurological disorders in vitamin B12 deficiency: pubmed.ncbi.nlm.nih.gov/31094...
Clinical, nerve conduction and nerve biopsy study in vitamin B12 deficiency neurological syndrome with a short-term follow-up: pubmed.ncbi.nlm.nih.gov/24256...
Coma and Axonal Degeneration in Vitamin B12 Deficiency: jamanetwork.com/journals/jama...
Clinical and Brain Imaging Findings in a Child with Vitamin B12 Deficiency: www.mdpi.com/2036-7503/13/4/69
Vitamin B12 Deficiency and Impact on MRI Morphometrics: Association Between Cognitive Impairment and Neuroimaging Findings: link.springer.com/referencewo...
Vitamin B12 deficiency manifesting as reversible leukoencephalopathy and ataxia: www.neurology-asia.org/articl...
Why it's not a good idea to keep vitamin B12 a secret: case report of thrombosis in the brain and hydrocephalus in a vegan in Sri Lanka: www.christiankoeder.com/2020/...
Vitamin B12 Deficiency Causes Chiasmal Lesion: www.reviewofoptometry.com/art...
Pseudo-Foster Kennedy Syndrome as a Rare Presentation of Vitamin B12 Deficiency: www.semanticscholar.org/paper...
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Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research.
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he video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information.

[@ellieperryman591]

I am 26 years old, not vegan, and about 3 months ago became very very sick with many neurological issues. Numbness, tingling, pins and needles, brain fog and derealization, weight loss, extreme extreme fatigue, and much much more. I went to the hospital twice because I was so sick and I knew I was so sick. They chalked it up to anxiety. Neurologist did a spinal tap and told me he was eventually going to diagnose me with NFD because he didn’t know what was going on. But b12 was tested. I was 125. They put me a supplement and told me to recheck it in a few months to see if it goes up. I’ve tried explaining to doctors that i need injections as my numbers were so low, such horrible neurological issues, and being on supplement with increase my blood levels but won’t explain where my absorption issue is coming from. I still have not found help. I’ve hit roadblocks because there aren’t specialists for b12 deficiency. My pcp and neuro both say b12 deficiency is really for the elderly, vegan, or bariatric surgery patients. I’m young and not vegan and have never had that surgery. Who do I see? Where do I go? I’m so so tired.

[@BEALWAYSHAPPY266]

Mine was 136 and doctor prescribed me 7 shots of mecobalamin 1500mcg for continuous 7 days 😢

[@traceytansley1659]

Keep seeking a doctor that will help you, prescribe shots and refer you to a neurologist...insist.

[@NikolaNacevski-bf6ip]

Hi there friend. Iv been DP/DR state 4 years with weight loss , visual snow and very fatigue .. Heart palps and skipped beats. I started supplementing b12 1 month ago with 1000mcg spray oral sublingual and Omega 3-6-9 and im getting REALLY better. Go to pharmacy and ask for this dont wait on doctors because ive been and they told me its all in my head

[@NikolaNacevski-bf6ip]

Just know Oral Sublingual 1000mcg is better than injections. Do a reasearch its new method.

[@frusia123]

I've read that even people with pernicious anemia absorb a little bit of B12 from supplements, around 1%. So if you use big doses like 1000-2000 units a day, that should help. You can't really overdose on B12, because like vit C it's expelled with urine if the body has too much. I take 1000 units twice a day, and my neuropathy practically disappeared after the first dose. Also my mental health has improved really quickly.

[@NikkiSoFar]

I’m taking B12 supplements & I love broccoli 🥦 Thanks for adding some humour to your video 😊

[@rhondadeitenbeck30]

No mention of MTHFR. I wish doctors would educate themselves about this condition.

[@miloradvlaovic]

Or HoloTC testing (suggested as a GOLD standard for B12 testing by the WHO). But this MD is far, far above in his knowledge about the matter particularly when compared to an average MD. Even if the average MD specialuzes in haemathology

[@ActiveVeggieTours]

kzbin.info/www/bejne/hJbQmJl5rMqDl8ksi=V-l__3aJexoXa04H

[@jonijohnson5110]

Thank you so much for explaining B12 deficiency. My labs showed B12 deficiency but normal MMA. I was definitely experiencing cognitive effects- like an extreme brain fog and fatigue. I read at home about intrinsic factor and wondered if the issue was in my stomach. I started taking B12 2500 mcg sublingual. The symptoms resolved almost immediately. I noticed that if I miss a dose I definitely feel it within one day. I had been following a mostly Vegan diet. Lots of vegetables and a cooked serving of Salmon every day. The Salmon seems to have been pivotal in improving my MS symptoms and strength. Dr said keep it up. The only problem was the B12 deficiency. I had no idea it was so serious. Thank you for your videos. I truly appreciate your content. 😊👏

[@tc397]

I would check about having salmon everyday as over time it can increase plastics in your blood, as unfortunately the oceans are full of plastic particles and is now found in the fish. Also too much salmon can cause high levels of mercury in your blood also. I wonder if you were sent to a gastrentologist to see if you have IBD, I assume they would only do that if the B12 tablets don’t bring your levels of B12 up. I truly feel for you as mine is always extremely low, the injections helped but they have recently put me on tablets only. I was a vegetarian but I eat meat twice a week now as I know the tablets won’t do the trick, I wish you luck in your search to find a doctor who will listen and explain in detail everything about your case to you

[@billytheweasel]

@@tc397 Yes, heavy metals in too much seafood. A must-know! I was vegetarian from 78-98 and partially after that. I ended up with metabolic syndrome and was shocked. In '78 nobody mentioned B12 and there was no internet, so I'm lucky - I did eat dairy so that probably saved me.

[@kara7197]

The sponsor bit is pure genius!🤣

[@robynnepeterson3798]

My great niece had all those symptoms, seizures and hallucinations, she said she saw fire come out when she plugged something in the wall! Now she had a MRI and it showed she had 2 brain bleeds. The doctors never gave her shots just pills. I thought since it was so low she should have had the injection B-12 for a while!

[@mbbohn7402]

Oral should never be given to treat PA or B12D unless it is diet related . If your niece can not absorb B12 from food, she should be on injections. Injections are for life, once our ability to absorb is gone we can not go back. 1% of oral can be absorb passively, enough to skewer blood test. Blood test pick up both active and inactive B12, we can not use inactive (Haptocorrin), which your body will remove in time. I hope your niece gets better treatment.

[@billytheweasel]

Many people must be lazy or just hand their lives over to doctors. This Dr I'd trust but it needs to be earned and demonstrated. I study everything and if it irks a Dr that I don't immediately comply - I take that as a clue to move on.

[@sherbitrio]

Was quickly reminded to hit the like button when speaking for your sponsor. Fabulous.

[@DrBrandonBeaber]

:)

[@hackett1181]

Brilliant! Enjoyed listening and passed along. Thanks!

[@ruthe3351]

Clear and concise as always. Love the broccoli 🥦🥦🥦 advertisement!

[@aalihte3378]

Boy I wish you were my neuro. So much good info. I definitely need to take b12

[@sectionalsofa]

Excellent video. Thank you so much. And I LOVE the word from our sponsor! Brilliant.

[@DrBrandonBeaber]

:)

[@bigrigchristfollower9020]

I haven't definitively been diagnosed with Multiple Sclerosis, I have had several MRI'S of brain, Several MRI'S of back because I had L4 and L5 disc issues wich I had a Spinal Laminectomy done July 14th of 2022, have been tested for Lupus, have been tested for Lyme Disease, have had test done for JC virus, have had CBC and several other things but after my Spinal Laminectomy I was still losing balance, having fatigue and here in May of 2023 starting to have back pain again. I am changing insurance starting next month the new insurance to see another Nuerologist closer to me and I don't say the other one is bad but I don't feel that they were interested in me the patient just like Aaron Boster states about styles and I know you know him because I saw the video you two did together and I must say I love both of you for the work you do so I pray Blessings over you both ❤️.

[@Lauren-vd4qe]

get tested for lyme disease; take vit D3 every day, magnesium every night, and i hope to #### you didnt get the meddispear.

[@kocs98]

Very informative video....thanks Doc!

[@uptoeleven]

Loved the ad from your "sponsor" there. Of course if you eat broccoli in a stir fry, add eggs to introduce B12...

[@joclothier5536]

You explain everything sooo well.This is my first viewing of your channel,and as someone who has B12 injections every twelve weeks I found out about some issues that I hadn’t heard of before....So I’ve subscribed to your Channel hoping to learn more about more health issues that affect me. Thank you so much.xx

[@DrBrandonBeaber]

Thanks, though I normally make videos about multiple sclerosis.

[@mgr2599]

Doctor, I subbed to your channel just now. I’m so confused by the information on B12. Does the oral, or kind you place under the tongue truly work, or are injections of b12 required?

[@pramuanchutham7355]

​@@mgr2599i take the Kirkland sublingual 5000mcg B12 and it works right away. Leg pain disappears within a minute of taking it. Why bother with iv-injection when you can take it as a candy under your tongue? 😊

[@cognoscenticycles4351]

Prolonged use of antacids can have a profound effect on not only B12 absorption but a long list of other essential nutrients and wreaks havoc with your health.

[@KB-eu5xi]

Love the advertisement. 100% would recommend 👌

[@rayvonkidd]

Do you know any covid related problems causing drops in b12/iron/folate?

[@oppressednolonger1497]

Great material, learning lots from this. Are panic attacks/ near syncope part of neurological symptomology of a PA / long term b12 deficiency, Dr B?

[@KMx108]

I can tell you from my own experience with PA that yes, those are symptoms

[@pattiecolom4564]

I was hospitalized for PRES last year. My b12 was way out of range..very high 1700's ! Now I have pernicious anemia w/ intinsic factor. Taking Zypan and B12 injections. Cognitive and physical symptoms have improved but my energy levels are still problematic.

[@mandybell7884]

Thank you so much for this info and the manner you explain. I appreciate you and this video❤

[@DrBrandonBeaber]

I'm glad it was helpful.

[@purposewithoutlimitstv3522]

Dr. Beaber. I have had a serve case of misdiagnosed PA and B12 deficiency. It was only recently ( 18 month ago) discovered. I have been giving myself self injections for about 15 months. I am dealing with hyper-mobility shifts as my body is slowly recovering. With this radiates pain throughout my back. Do you have any insight regarding how long it takes the body to heal. I haven't always had this pain or this spontaneous shifts in my spine.

[@fin1158]

Really good concise info. It's the best broccoli commercial. !

[@MadMax2022]

Thanks doc B for this informative episode. I just saw a post that Merck sp? Is working on a vaccine for ebv if a person has ebv already would a vaccine help ?

[@freedomhigh2160]

I am going thru what is diagnosed as carpal tunnel syndrome, I did not opt for surgery as that is treating the symptom. This diagnoses doesn’t make sense to me as I don’t perform functions that would usually cause this issue. Could it be a B12 deficiency ? I do take supplemental vitamins and am not a vegan but I could have some of the intestinal disorders mentioned that are inhibiting the absorption of B12. I wish I had a doctor that could diagnose this properly. I don’t want surgery for something that only masks the underlying problem. Can you offer some advise ?

[@alisonbamford6723]

B12 can be hugely deficient at cellular level even when serum levels are ‘normal’ (whatever that ‘really’ is) or even high when the body can absorb it but not convert it to its active forms, Methylcobalamin & Adenosylcobalamin. I suspect this issue is far greater than is currently believed. Unfortunately, serum tests do not show what is going on at cellular level, nor do they determine what percentage of the serum B12 is active or inactive. If most in the bloodstream is inactive it isn’t getting into the cells & the serum test is meaningless……. That is why knowing & understanding the symptoms is at least as, & if not more important as the tests. And why a huge swathe of the population continue to struggle with B12 deficiency issues, because few doctors recognise or understand the symptoms, & most rely solely on serum test results. My own husband collapsed last year. From his symptoms I strongly suspected B12 deficiency, but when the B12 test (that I’d had to request as the doctor didn’t do it) results came back at 360 the doctor dismissed it. Faced then with the prospect of having to go into hospital for more tests, which in the CV climate scared Hub witless, he decided to try my sublingual liquid drops with both active forms. I triple dosed him (6 x half dose per day) for just over a week, but within 2 days he was starting to rally. Within about 10 he was pretty much back to normal - & with better energy. Had the doc given him loading doses his recovery might just have been quicker. All the Doc said was, “if it’s working, carry on”. Thanks for nothing, mate. Hub is 81 & a meat eater, however older people don’t always absorb or utilise it very well. Absorption & utilisation are not the same thing. B12 has to go through at least 4 stages to be available to the body & can potentially fail at any one. If you can absorb it but not use it, you may appear to have ‘plenty’ yet still be in abject deficiency-land & end up falling through the misdiagnosis or undiagnosed cracks…… One astute doctor found that at least 50% of his patients were B12 deficient whether they ate meat or not, including ones misdiagnosed with neuro issues such as MS.

[@mbbohn7402]

Many patients are misdiagnosed with MS, and many more are over looked because of false high blood serum levels. It's is a horrible epidemic.

[@emeraldbrown692]

Hi, I’ve had a bunch of neurological issues for 1.5 years from a virus I caught. I was told by someone I may need b12 injections but to go get tested first by my doctor. My doctors are ignorant when it comes to reading my bloodwork. I honestly don’t want to do b12 injections and noticed you did sublingual b12 with your husband. Is it still helping him? Also, I’ve heard when you take b12 you have to check other vitamin levels because certain vitamins work with b12.. it’s just so much and I really want to get better.

[@alisonbamford6723]

@@emeraldbrown692any kind of stress or trauma to the body, such as illness, virus, surgery, accident, bereavement, divorce, job loss, medications/drugs/Vxs, etc drain the body’s ’stress-management’ nutrients like the B vitamins & Magnesium, something awful. The B vitamins are crucial for Nervous System health, support & repair.

[@KMx108]

It's such a shame that so many doctors are ignorant of this. They are actually doing their patients harm in some cases. Some are too arrogant to listen to patients who actually know more than they do on the subject.

[@alisonbamford6723]

@@emeraldbrown692 yes, he is still taking it & it’s still working.

[@desiredecove5815]

Awesome vid Beabs. ❤ #Sharingiscaring

[@lesliex7894]

Very, very informative. Luv your sponsor. I'm WFPB so would like more info like this. I take a B12 supplement daily. How much do you recommend? Reminds me to check on blood work my new neuro ordered. Thx

[@user-jc6ok6cf7m]

Excellent video about B12. Thank you for posting this video. M

[@DrBrandonBeaber]

you're very welcome

[@lesliex7894]

Something similar on calcium would be good. Osteopenia (60yo F ) and concerned about falls.

[@sl4983]

Have you learned anything? Following

[@eval1409]

I’ve seen patients with clinical suspected deficiency, B12 in low normal range where MMA is only slightly elevated or in the upper range. Checking MMA after one singel injection with hydroxycobalamin, and observed a reduction in MMA with up to 50% after 10-12 days. Would you concider this a sign of cobalamin deficiency at a cellular level?

[@KMx108]

I'm a patient who had b12 in the normal to high range, MCV was slightly above normal, MMA was normal, but had neurological symptoms and a long list of b12 deficiency symptoms. I was told my condition was psychosomatic but Methylcobalamin injections reversed my symptoms. I then tested positive for intrinsic factor antibodies and was diagnosed with pernicious anemia. I was using a wheelchair by the time I was finally diagnosed and my MMA was still normal.

[@user-ob9zw8is8s]

In what ratio should I take Vitamin B6 & B12.anxious 74 year old who’s cognitive Brain is in my option declining.I also suffer from Sciatia and Carpal tunnel. Irish follower.

[@mec4142]

Know that a person can have levels at 2000+ and be literally dying from b12 deficiency. Wish my doctors would have been knowledgeable instead of pharma pushers and the “your labs look great, no issues” while the list of complaints exceeded 50 symptoms. But hey it’s juts anxiety or depression right. Homocysteine was not elevated nor was MMA. B12 injections saved my life. And luckily I figured it out before the wheelchair and I was able to reverse the dementia symptoms.

[@binathere2574]

Congratulations. What were your symptoms, if you dint mind sharing? I saved my own life as well. The doctors were clueless. 9 months of daily injections and I'm starting to feel normal.

[@KMx108]

Same happened to me but they told me my symptoms were psychosomatic and treated me like a pest every time I came in with a new complaint. I was permanently kicked out of 3 doctors offices for trying to advocate for myself before realizing that my shared electronic medical chart was causing them to be biased and not provide reasonable care. I ended up diagnosing myself and then sought an unbiased doctor to confirm it. I was using a wheelchair by that time. I've been told this has caused me to have medically induced trauma. Just what you want to get when you're already dealing with a long list of problems. Thanks, docs!!!

[@narasantos7229]

Hello,​@@binathere2574. I have been facing the same problem! From Hyperventilation Syndrome to Multiple Sclerosis, they have investigated everything, except my b12😢 I started taking b12 shots 1 month ago. How much b12 do you take daily?? And how do you feel now? Are most symptoms gone?? I would really appreciate if you could share your journey with us 🙌🏽

[@jaysherman4149]

Me too. Luckily I had a friend doctor who prescribes me injections.

[@nigelwoolcott2012]

In the UK we have a normal range of 38-188 pmol/L which is well below your figures. It makes my 75 pmol/L 'normal' but severely depleted by your levels?

[@michelleharisson2270]

My brother and I have multiple Cytochrome P450 faults that stop us converting B12 to a bio available form. Is this common? We both get regular injections and take folinic acid.

[@DrBrandonBeaber]

There are genetic causes of B12 deficiency, but they are extremely rare.

[@enecity]

Thanks Dr for this highly informative piece. I have lost my balance for about 4yrs now with with a terrible reflect on my knees and ankle. Tingling sensations on my feet and palm. Have discomfort around my pelvic and hips. Started experiencing erectal dysfunction about 2years ago. Ran many test with MRI but no definite conclusion that it is MS or cervical spondylitis. It was recently discovered i was low in B12. Could the b12 deficiency be the cause of those symptoms? I have been on b12 supplements for 2months now and no sign of improvement. Do i have hope?

[@DrBrandonBeaber]

I hope you get bet better, but there would be no way for me to comment on your specific situation. Symptoms related to B12 deficiency can bit wholly or partly reversible.

[@sherbitrio]

Try sublingual B12 tablets; they absorb better than pills you swallow.

[@jigar1p]

Yes, your symptoms could be related to B12 deficiency. Get MMA and homocysteine done. You probably need higher doses as may not absorbing it by mouth. Try B12 injections.

[@zuma5443]

Thank you very much!

[@joshmckinney6034]

This is very informative. My mother has pseudo dementia from pernicious anemia. Brain scans look normal and she is taking b12 supplementation. In your experience would the dementia be reversable? We started noticing symptoms a few years ago and it just kept gradually getting worse until we thought she had alzheimer's.

[@DrBrandonBeaber]

Sometimes people with b12-deficiency related neurological disease can make dramatic improvement if treated early.

[@hildazeigler4664]

Thank you ever so much - this was very informative

[@DrBrandonBeaber]

glad to be of service.

[@megamediker]

Very interesting details. Being a typ 2 diabetes patient I suffered after taking Metfromin. My working day literally ended after 4 hours. I kicked out the metformin, even though my doctor refused the motion and changed my therapy to insulin myself. (I am a pharmacologist) Sublimating B12 helped me instantly. Plus I am still in need of supplementation, even after changing to insulin and even though my nutrition is normal, except low levels of carbs in my diet. If I don’t supplement B12 constantly I get tired after about 2 weeks and my mental capabilities decrease. Thanks for this comprehensive information. What is the regular dose for supplementation? What are your eperiences. Do you have any information, what too high dosis of B12 may cause, can it be overdosed? So thank you so much. Roland from good old Germany.

[@pramuanchutham7355]

Dr.Coppola, the Nerve Doctor, suggested 10,000mcg B12 as the 'optimal dose' for neuropathy. Have no fear of overdosing with Methylcobalamine B12 as the liver stores upto 5mg for several months' use. Don't take the toxic Cyanocobalamin at such high dose!😮

[@anjaliacharya3259]

I m vegan and diabetic. I suffered from fatigue for months and months. Recently I started supplements , and feel some what better. But I have neuropathic nerv pain which doesn't heal

[@njvanheerden2157]

What a brilliant doctor you are wow.

[@DrBrandonBeaber]

Thanks

[@andrewreisinger6860]

Excellent video! What is a good amount for B12 supplementation? Is the amount in a typical multivitamin sufficient?

[@DrBrandonBeaber]

For people with b12 deficiency with neurological manifestations, I recommend 1000mcg subcutaneously weekly for 4 weeks and then monthly for 6 months in addition to 2,500 mcg sublingually daily. For just general supplementation for vegans, as low as 2,500 mcg sublingually once weekly may be sufficiency. Many people take 2,500 sublingually daily.

[@Cat_in_Spacetime]

Hey doc, I had similar cognitive decline and extreme fatigue. I'm on lacto-vegan diet from birth. I usually had b12 and multivitamin supplement along with Calcium and Iron supplements sometimes. Yesterday I had my blood test report The b12 levels was very low 126.6 pg/mL Docter asked me for Injection or Nasal spray (500mcg/dose) alternative days Please tell me doc, Should I go for Injection or Nasal spray?

[@samantharogers9147]

Thank you for the vast information. My great great grandmother died in the late 1930’s from this and was listed as the cause of death on her death certificate. Several of my cousins and I have it also. We have a lot of early onset Alzheimer’s. Could this be confused with dementia from B12 deficiency or correlated? Are there any studies of this?

[@jigar1p]

Yes B12 deficiency will cause cognitive changes that can be mistaken for dementia and depression.

[@yatesmsw]

My mother died with dementia, and I strongly believe B12 deficiency was a big cause.

[@jaysherman4149]

It could be confused but there are not really studies. I did find an old study that a pretty high percentage of people over 65 are deficient and this generally goes undiscovered.

[@chvckn0rri5]

I have an issue metabolizing B12 in its available form. I have MTHFR. I have a single lesion on a brain MRI. I have left side weakness (stroke ruled out). My short term memory barely functional. Can you give me some advice on navigating this? Do you have any information on this?

[@DrBrandonBeaber]

I cannot comment on your specific situation, but MTHFR testing is commonly misinterpreted. You may appreciate this article: www.ahajournals.org/doi/10.1161/circulationaha.114.013311

[@EvenSoItIsWell]

Thanks so much for pointing out that being vegan is not a major cause of B12 deficiency!! And I love that you are being sponsored by broccoli! I am a big fan.

[@DrBrandonBeaber]

I don't normally accept sponsorships, but I got such a huge offer from the broccoli foundation, I couldn't turn it down. 🤣

[@EvenSoItIsWell]

@@DrBrandonBeaber 🤣😄😅

[@ernietollar407]

ditto to addressing the B12 myth as well as the rare supplement treatable scenario

[@EvenSoItIsWell]

@@ernietollar407 yes!

[@kevindonnelly7475]

Highly recommend getting your methylation genes tested to see if they are functioning properly. Directly affects B12 absorption. Mine are mutated and I have poor B12 absorption.

[@gabriellepennycook-lc8is]

Brain fog ongoing for 3 months now. I has a b12 of 177pg/ml. O had 4 b12 injections within the first month. My intrinsic factor came back normal. And have not been taking 1000ug unit per day. The dizziness, fatigue and headaches are beginning to lessen. But the brain fog (feels like im under water in my head) haven’t got any better. Any suggestions on why or how long this may take to recover. My symptoms started about 2 weeks before i got the injections so it was long standing. Great video. Thanks :)

[@tracyclayton3840]

Its awful isn't it? Sending hugs

[@Sumit_Girhe]

How is it now ?

[@KMx108]

Methylfolate resolved this symptom for me. It's a cofactor for b12.

[@myvideos9614]

Can you do a video on PANDAS and PANS? B12 deficiency can also cause OCD.

[@DrBrandonBeaber]

I am an adult neurologist and these topics are outside of my expertise.

[@user-ys2hu5id7e]

I seem to have had low b12 (225 and below ) since 2017. Just picked up recently . The changes in my gait really concern me. Can I expect the gait to come right as I continue to take b12 subcutaneous and my b12 level now stays above 400. My doctor kept saying it was ‘within the range’. So long time to get treatment .Thank you

[@sq5]

I have Pernicious Anaemia. When they finally discovered this, my B12 level was 50. Yes, fifty. They said that there was no evidence that I had ever eaten anything with B12 in it in my life. I am not vegetarian or vegan. I was extremely ill, physically and mentally, having declined in health over 7 years before they thought to do a blood test. My gait was one of the things that was affected, along with pretty much every other symptom you'll hear of. After diagnosis, I had an injection every day for a week, then was told to have them every 3 months. That wasn't enough. I became very ill again in between dosages because they were too far apart. Even though my test results were, "normal," I was most definitely not functioning normally. I had to insist on having more frequent injections, (which my doctor subsequently taught me to give to myself). My doctor said for me to go and see him when I felt really good after doing my own injecting routine for a while and we would test my levels. I did. My levels when I felt at my absolute best, were 1,600. He said that clearly I need 4 times the reading of the average person for my body to work properly, and since then, he has left me in charge of my own dosing, as there is no need for a prescription where I live. I now have injections every week if I'm very active, and every 2 weeks if I'm not so active. My gait is permanently affected due to nerve damage in one leg and part of my back, but is better when I have treatments this regularly. I do still get foot drop when I'm very tired, even on regular treatment though. Fatigue does matter, as does muscle weakness. Try and stay as strong as possible to help the situation. So sometimes, even a, "normal," reading isn't enough for some of us. It really does depend on your body. Perhaps you could ask your doctor to do a similar experiment with you and see what pans out. Hope that helps.

[@janeteddddd]

​. It is heartbreaking to read what you gave been through. How are you doing now ?

[@davidneumann9653]

Wow great job! What about D3 with?

[@paulasusan63]

Brand and dosages recommended?

[@RonaldBeirouti]

Great video as always! Since brocoli is not a good source of B12, what is recommended for supplementation. I am quasi vegan, take a B12 pills every day. The bottle says sublingual but I just swallow with my vitamin D and iron. Is oral a good way to supplement?

[@beckiwildeman600]

not the best. Let the pill melt under your tongue

[@RonaldBeirouti]

I asked my pharmasist last month regarding sublingual vs just swallowing. He told me that it ends up the same. It just takes longer to absorb but if you don't have an immediate need for the B12, if it's just for maintenance, it's the same.

[@hannah5245]

When should I take B12? Morning, afternoon or nighttime?

[@agamemnon7461]

I had my B12 tested 1 time over the last 6 years and it was 3 years ago. It showed 218pg. At the time the doctor said it's normal. I just reviewed the result and figured it was at the low end. I am not consuming animal products as I used to by then and I am feeling weird symptoms but the most alarming is my gait. Not being able to walk and always afraid to fall until going out become a real anxiety source!

[@Dietconsulting]

Request a test and ask it is done annually if you are not eating animal products.

[@PassionLeavesATrace]

Did you try b12 supplements?

[@MikeD_]

I discovered I was B12 deficient with a 240 pg/mL. This is within the normal range, although at the lower end. Regardless, we now know that a not insignificant portion of the population within that range experience B12 deficiency symptoms. I'd go to your physician and request a blood test since you were barely above normal three years back, and even if you're still in the normal range, request B-12 injections.

[@jigar1p]

Get your MMA and homocysteine levels checked.

[@gregb8571]

It could be Parkinson's.

[@KarunaGovindasamy-sm7nn]

Thank u so much doc❤

[@billytheweasel]

Subbed, glad I found this channel! One Dr said cyanocobalamin is harder on the kidneys that methylcobalamin. ... true?

[@m.b.calderhead268]

Thank you for such an info-packed video. Could you explain the neurological change I am experiencing in my 83 year old body. Feet mostly …. little swelling in the feet that is curbed by elevating my legs up against the wall for about 20 minutes per day. I’ve been mostly healthy my whole life but can’t find the balance now.😊

[@KMx108]

You might benefit from compression socks. I'm in my 40s but when I had circulation issues, it turned out to be related to b12 deficiency.

[@butterflyblueshorts]

I was diagnosed with pernicious anaemia at 27 and it was a long road. I've always had tremors, brain fog and memory loss. Can I ask, would you expect further decline in these areas after treatment has begun? or does the decline level out to within usual decline for general population. Thanks

[@DrBrandonBeaber]

I would not expect worsening if the deficiency is adequately treated.

[@butterflyblueshorts]

@@DrBrandonBeaber Thanks for the reply and the informative video. I'm sure you're very busy and its appreciated.

[@lararose9106]

​@@DrBrandonBeaberhi there Dr. Brandon😊 ive always had b12 deficiency but afraid to take it because ive heard they may cause allergic reactions. How important is methylcobalamin for MS patients and if so what doses do you recommend to help regain muscle and nerve strength as well as help with my dizziness and imbalance

[@DrBrandonBeaber]

@@lararose9106 B12 deficiency is dangerous in its own right but not specifically associated with MS.

[@lararose9106]

@@DrBrandonBeaber does it improve ataxia and dizziness though coz thats what ive been told that it wud help greatly👌

[@kellyofthehead]

I believe both myself and daughter to be very low in b12, my daughter is only 14 and her levels last year were dangerously low. She was given the loading doses then they stopped them and said she didnt have pernicious anemia. Her diet is no different (she eats meat and dairy) how can she suddenly not need it?! I read the Intrinsic test was only 40-60% accurate? I have some scary neurological symptoms that look like als after aome spinal surgery last year for Cauda equina, two surgeries as it happened twice. I was given nitrous oxide both times for pain. Years of ppis too for ibs symptoms. Diagnosed two years ago with M.E/CFS. I have an appointment with a neurologist next month as I've developed poor balance, neuropathy, full body fasciculations and I'm so worried they won't listen to my fears of B12 deficiency. My numbers just meet the lower end (230mol) how can i make them listen?

[@jaysherman4149]

Find a better doctor. Most won't listen.

[@nancywinters2200]

What is the out come for recovery of a person in there early twenties for recovery from B-12 deficiency when treated with B-12 due to excessive use nitrous oxide?

[@elizabethtimke3760]

Curious about paradoxically high b12 levels? I got diagnosed with optic neuritis (other symptoms include fatigue, dizziness, numbness, tingling and worsening mental health. Neurologist is working me up for MS. So far tests are coming up negative still pending mri of spine. B12 was 1300. I do have macrocytosis but a normal hemoglobin at 13 (I'm homozygous for h63d gene). Thought to add also compound heterozygous for mthfr (I know debated in medical community). Can you have a very high b12 and still have a b12 deficiency?

[@chloe9904]

Have you been supplementing? If you're supplementing B12 it can show you have high B12 levels in your blood when actually you don't! So yes it is possible!

[@JnTmarie]

Love you ads lol thank you for this video!

[@stupud818]

Can serious b12 deficiency or non absorption be misdiagnosed as ms?

[@crocussaffie2680]

Super weird question. I was diagnosed with MS despite a odd presentation. In the blood test they noticed I was low and B12, I live in a small town so I just got B12 complex liquid because that’s all I saw within an hour of taking it I could hardly walk or stay awake it was terrifying… Any explanation?

[@sl4983]

When I took a half chewable of b12 methyl , I got toe pain

[@Go-pointl]

I would love if this doctor addressed your question.

[@beckiwildeman600]

What form of B-12?

[@crocussaffie2680]

@@beckiwildeman600 liquid b complex… no but I was just diagnosed with reactive hypoglycemia… non diabetic

[@beckiwildeman600]

@@crocussaffie2680 I understand liquid but is it methylcabalamin , Hydroxcabalmin or cyanocabalamin?

[@dr.dodology9217]

hank you so much

[@theresahaas6910]

Nicely composed, really valued the examples. As someone with IFa PA, on optimal treatment, is there a reason you chose not to address the issue of injections only for those who cannot absorb standard supplements? It is known that supplements (tablets, sublinguals) will falsely raise serum levels which many medical practicioners fail to recognize, contributing to the unfortunate continued detriment of patients.

[@KMx108]

Well said

[@sarahmurray3368]

Do you by chance have a video on anything to do with recovery from b12 deficiency? I’m currently going through weekly injections after years of chasing for a test. Finally was discovered that I had “no registering reading for a level” I was so low. I’ve been dealing with severe mental health issues and was diagnosed and medicated for them in that time. I’m now struggling with the flood of ups and downs during the process of “waking up” and I don’t know what to expect, what’s normal, or what I should see as possible red flags to let my doctor know about. I’ve had head injuries and also diagnosed PCOS so feel very disconnected from the body I’ve been trapped in for quite some time now.

[@jaysherman4149]

Get methylcobalamin injections at least weekly. Take sublingual adenosylcobalamin daily. Take a multivitamin. Eat plenty of legumes. Avoid alcohol.

[@imtryinghere1]

You are very good doc. Highly efficient and informative

[@DrBrandonBeaber]

Thanks

[@missskeetchie]

What if you have very high levels of b12 without taking any supplements? Last 6 months 2 tests are showing mine to be up in the 900s, I’m in Canada if that matters

[@PassionLeavesATrace]

You most definitely eat a lot of b12 rich foods and maybe don't drink alcohol

[@binathere2574]

A high serum B12 doesn't always mean you have adequate b12. You need a HoloTC test. This measures the cellular level of B12.

[@KMx108]

I had high b12 without taking supplements. Eventually, I was diagnosed with pernicious anemia due to a positive intrinsic factor antibody test. My understanding is the b12 serum test can mistakenly count intrinsic factor antibodies as b12 and give a falsely high reading. You could also be getting b12 from unintended sources, like energy drinks. That's the case in the US. I'm not sure if Canada is the same.

[@randomstuffman01]

Wow. That's a lot a great information. Thanks. toronto canada.

[@DrBrandonBeaber]

:)

[@cherylnavarrete4198]

🥦 😂 So do you think taking b12 supplements are worth it? Future video on how much your thyroid may have to do with MS? Thanks

[@SudoRndCmd]

I loved the sponsor of the video 😂😂😂

[@lillyjane78]

I have severe parosmia after having very mild covid twice and I can't eat eggs, cheese, meat, or nuts anymore. I'm so sick. I am having a hard time remembering to take supplements.

[@workhard6261]

I am a second year medical student. I am afraid of the bloom of the AI in the medical field, thinking that it might take over the physicians in the near future. What should I do? I am really confused.

[@DrBrandonBeaber]

If AI becomes good enough to replace you, it will also be good enough to replace most other professions, and society would fundamentally change. I have a video on this topic: kzbin.info/www/bejne/g5CoZIBoZtaDj7M

[@workhard6261]

@@DrBrandonBeaber thanks doctor for the response!

[@susanedghill6597]

Will it help inflammation. ?

[@denisemurray149]

When having bloodwork done to recheck low levels of b12, is it ok to still be taking sublingual b12? I have been told not to stop the sublingual b12 by my dr, but the phlebotomist told me I should for a month or so because the serum level will look normal range even if the b12 level is still low in my body. I reported that to my dr who basically said hogwash. I’m so confused. My number was 96 based on 200 as a low result. I have terrible neuropathy and other symptoms, so I want to make sure I do this right. I’ve only been taking 1000 sublingual methyl b12 for one month and he wants it retested.

[@KMx108]

My prediction...your supplementation will make your serum level appear higher, your doctor will tell you your b12 is now normal. You will still have symptoms and your doctor will tell you they are all in your head. This seems to be how they are taught to "help" people. You need to find out why you are deficient and address the root cause. You may need injections. Pay attention to your symptoms and don't accept anyone telling you it's fibromyalgia/CFS/FND/psychosomatic.

[@sl4983]

Yes the fish tapeworm is very much in the United States also.

[@KMx108]

Even if it wasn't, there's this thing called international travel.....doctors in the US amaze me sometimes. Not in a good way.

[@sl4983]

@@KMx108 They try to hide itt

[@jaysherman4149]

I was supplementing and at 321pg/ml and deteriorating with the same symptoms that years before had been a b12 deficiency. When I finally got injections I rebounded. Unfortunately that wasn't easy to get because my level was considered too high for injections. They were absolutely necessary though.

[@vaness7437]

Any ideas on where to find methylcobalamin or hydroxycobalamin injections? (My terminal ileum was removed and I have permanent neurological damage already, so need injections.) When I was able to pay to see a naturopath and given methylcobalamin, my levels finally went up to 700 and stayed high for months, I finally didn't feels so tired, whereas with the standard cobalamin injections from my allopathic doctors, my levels are rarely above 300 even with twice/month dosing.

[@jaysherman4149]

A mail order pharmacy such as Empower. But a doctor has to prescribe it. Otherwise it's easy to get in Mexico and some other countries.

[@ConstructiveMinds100]

Coolest ad I have ever seen. ❤

[@DrBrandonBeaber]

:)

[@anonymouscatlover5571]

Thanjs

[@melbrown4780]

I love the words from your sponsor, Broccoli. Very cute. Had me laughing out loud 😂

[@DrBrandonBeaber]

I'm still raking in the residuals :)

[@jillfougerousse6705]

My mother is in. a wheelchair due to idiopathic neuropathy. She has very little motor control in her lower extremities. She has severe balance issues. She has been across the country to see many doctors. Never was b12 deficiency considered until I myself discovered I was deficient as well as my daughter. I asked my mom to get checked. She was deficient and treated with cyanocobalamin. If she has the mthfr genetic mutation (we don't know this, just speculation) should she be injecting a different form of the b12 vitamin.

[@beckiwildeman600]

I would say yes > From what I have seen in my studies of the the different ones Hydroxocabalamin would be top of the shelf than Methyl cabalamin followed by Adensoylcabalamin

[@amr5427]

Yes, those with MTHFR mutation need methylated forms of B12 and folate. Methylcobalamin is the natural form of B12. Cyanocobalamin is synthetic with a cyanide molecule attached that the body has to process and eliminate. I would personally always choose natural forms over man made.

[@vaness7437]

@@beckiwildeman600 Unfortunately I've found it's extremely difficult to find a doctor who will prescribe hydroxo or methyl, and it is extremely frustrating. When I was able to afford a naturopath, he gave me methylcobalamin (I agree with you that hydroxo sounds like an even better choice), and my levels finally got up to 700 (couldn't get above 300 with 2x/week cobalomin), I started having more energy, and didn't need to inject any more for 2 months! But my primary care, GI, and hematology doctors claim they can only prescribe cobalamin!

[@binathere2574]

Low white platelets are also included in the anemia. There are 3 types.

[@charles2675]

I do take. Started

[@amandasue1686]

Can you link the literature that shows that average levels of b12 and b12 deficiency can still happen? I have raised instrinsic factor and have greatly benefited from IM b12, but my hematologist thinks I have nothing wrong with me.

[@DrBrandonBeaber]

Here is an example of someone with subacute combined degeneration of the spinal cord who had initially normal B12 levels: www.ncbi.nlm.nih.gov/pmc/articles/PMC2769328/

[@willie_mellow]

Live in ohio, where can get someone help with this? He has pseudo dementia according to the neurologist at mmh and is only being treated with antipsychotics which he has a bad reaction with.

[@DrBrandonBeaber]

The term "pseudodementia" typically refers to decline in cognitive function associated with depression, and treatment is treatment of the underlying depression.

[@darlenefrost2621]

What if I'm to high on B12 . I only get in once a month. Sad I use to have it my doctor says way to high. Stroke anemia and long time Cacer of the bladder.

[@KMx108]

B12 is not toxic and there's no such thing as a b12 overdose. Your doctor should focus on treating your symptoms, not managing your serum level when it is on the high end of the range. When I am taking injections, I refuse subsequent b12 serum tests because they are pointless.

[@0xmmn]

6:41 laughed hard at the sponsor of the today video.

[@DrBrandonBeaber]

:)

[@lindacezanne1576]

My B12 is in the 700 range, I am over 70, eat meats, veggies, etc. I have pins and needles in my hands and an elevated MCV. I have had many blood tests due to the elevated MCV and they show no anemia.Is it possible I am not absorbing the B12 even though it appears to be rather high? If so, what does one do about that?

[@DrBrandonBeaber]

Sublingual b12 supplements help to overcome poor gastrointestinal absorption.

[@lindacezanne1576]

Thank you!!! @@DrBrandonBeaber

[@isladurrant2015]

Subscribed x

[@tine5278]

Will check out this broccoli 🥦 thanks!

[@dardarlizard]

I had been dealing with severe light sensitivity for nearly a year. My VA neurologist has yet to figure it out. I tried taking 2,000mcg of B12 to help with low energy and my eyes started getting instant relief....... Now it's part of my regular regimen and my eyes are drastically better after a month but I expect it to take at least a year or so for proper recovery and I'm okay with that because it's working. I need to call my neurologist and report my findings.

[@MikeD_]

Request B-12 inter-muscular injections to greatly speed the process.

[@kunalrathod17]

I have been having very low cognitive function which made fail my exam since last 1 year (i have problem understanding even trivial things, remember and recall daily things, problem thinking), i eat all food i have at home but still observe no weight gain, could this all be because of vit b12 deficiency?(im an omnivore)

[@Sumit_Girhe]

How are u now man , going through same shit.. what is ur b12 lvl ?

[@alanazhen9805]

any updates? i’ve been feeling the same way for 2 months now and it all happened in a sudden, I’m too forgetful and my memory has become so poor, and my marks has been dropping heavily from what I used to get at school, i’m struggling heavily, got an MRI scan, and it was all normal, but still haven’t done a B12 test? Could the B12 be the reason for my poor cognitive function along with dizziness and chills and skin hyperpigmentation?

[@Sumit_Girhe]

@@alanazhen9805 check vitamin b12 & D

[@KMx108]

​@@alanazhen9805skin hyperpigmentation could be Addisons disease. Ask your GP to test your cortisol. You may need to see an endocrinologist.

[@KMx108]

I had similar symptoms. I was diagnosed with pernicious anemia but you also could be experiencing the effects of mycotoxin exposure from mold. Mycotoxins can alter the metabolism of B12 in the body. Your b12 serum level can appear to be normal but the b12 isn't getting into your cells. There are PubMed papers on this if you want to research it. Most doctors know nothing about mycotoxins.

[@maisydaisy1000]

Hi Dr can low B12 be a cause/factor of FND?

[@DrBrandonBeaber]

I'm not aware of a direct connection.

[@KMx108]

I know of people who have been diagnosed with FND only to find out it was actually b12 deficiency.

[@nicolle1532]

Hello Dr. Beaber your video is very informative. I’m 51 and finally dx w/ PA IF ABs as well celiac disease. I say finally because it’s been many years probably over 10 years or even longer since this is a slow progressive systemic neurological disease. I was the one who reviewed years of my medical records then asked my primary to test me for intrinsic factor and parietal cell antibodies. I also deal with iron deficiency anemia. I had two series of iron infusions. One recently and another 10 years ago. I still feel horrible my blood labs are not changed much plus my primary and heme doc do not order the correct panels to monitor me. My question is referring to the transport of iron … can our bodies make antibodies a protein involved with hemoglobin and maturation of RBCs? In another video please explain the transport cycle of iron. Thank you.

[@DrBrandonBeaber]

I am not sure about this. There are many cause of anemia, most of which do not have an immune-mediated etiology.

[@aleasegates3442]

Thank you so much Dr Beaber for this video.. very informative. I do have a question.. what is the daily dose of b12 for someone over 55?

[@MegBHikes]

Wow, this doctor just responded to you like he has no idea that there are autoimmune diseases that affect iron and B12 absorption!!😡🙄 I also was diagnosed with Celiac Disease, autoimmune metaplastic atrophic gastritis, pernicious anemia, iron deficiency anemia, and other nutrient deficiencies. I started with getting my magnesium sorted, slowly and with zinc. Then, vitamin D with K2 MK4 cofactor. Then I got an iron infusion. Took lots of vitamin C. Then started sublingual B12 adenosyl, methyl, and hydroxy forms- high dose with folinic acid 1:10 . Don't take magnesium oxide. Don't take cyanocobalamin. Don't take folic acid.

[@msfabre82allday92]

What about the importance for a b-12 when dealing with multiple sclerosis?

[@DrBrandonBeaber]

I'm not aware of any specific association.

[@drcarriemills8772]

Food is either medicine or poison. Firm believer in parasite cleaning.

[@JustChrissytheCrone]

I have pernicious anemia and am glad to see this video! I avoid allll the things..nitrous, etc… I first was diagnosed with PA later got the diagnosis of MS. Great video. I inject b12 weekly for life per my primary care.

[@JustChrissytheCrone]

Adding due to injections my primary will never go with what my blood work of b12 is cuz my intrinsic factor was not there 😂 so I’ll always show my b12 is okay…I inject on Fridays 1000 mcg and by Wednesday I’m at 700 or less. I was told I only absorb 1% of what I eat….

[@millennialhmong7121]

Love your broccoli spons😂r. It made my day😊

[@DrBrandonBeaber]

:)