Death is Inevitable but Aging is Not

Age is not the definitive factor it’s made out to be when it comes to our health. We can use our age as a baseline for tracking our health and longevity, but it isn’t stagnant. For example, certain types of testing can help us compare our biological age to our calendar age in order to tinker with our wellness routine and achieve the milestones we’re after. With the right steps, we can slow down and even sometimes reverse the aging process.
When it comes to our biological age, or the measure of how well our body is actually functioning for whatever life stage we are in, there are many things that impact it. Diet, lifestyle patterns like exercise and sleep, and stress are all involved in forming our biological age, along with many other factors like blood sugar, inflammation, and genetics. This week on The Doctor’s Farmacy, I’m joined by Dr. David Sinclair to explore the topic of longevity and anti-aging and how he reduced his own internal age by more than 20 years. Dr. Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, where he and his colleagues study longevity, aging, and how to slow its effects.
This episode of The Doctor’s Farmacy is brought to you by ButcherBox. Now through September 29, 2019, new subscribers to ButcherBox will receive ground beef for life. When you sign up today, ButcherBox will send you 2lbs of 100% pasture-raised grass-fed, grass finished beef free in every box for the life of your subscription. Plus listeners will get an additional $20 off their first box. All you have to do is head over to ButcherBox.com/farmacy
_____________________________________
Dr. Hyman is an 11-time New York Times bestselling author, family physician and international leader in the field of Functional Medicine. His podcast, The Doctor's Farmacy, is a place for deep conversations about the critical issues of our time in the space of health, wellness, food and politics. New episodes are released every Wednesday here on KZbin, and wherever you listen to podcasts.
Find him and more of his content all over social media:
Website www.drhyman.com/
Facebook / drmarkhyman
Instagram / markhymanmd
Twitter / markhymanmd

[@drmarkhyman]

Get my FREE guide 3 Steps to Reverse Aging when you sign up for my weekly health picks 👉 bit.ly/IncreaseHealthspan

[@amandaholst3826]

LOVE THIS. Dr. Mark Hyman never fails to bring the goods 😊 Thank you for sharing ❤

[@FLJD427]

Great info. Thanks. I am going to get Dr. Sinclair's Book "Lifespan - Why We Age and Why We Don't Have To".

[@neeloferkhan6033]

Thanks David and Hyman for the most interesting video on health. Keep up the good work. You both are awesome in your own ways!

[@Nilsosmar]

Great interview, focused and on-topic.

[@BrentNally]

I’ve been interviewing longevity experts in 2019 on my KZbin channel. I interviewed Liz Parrish in July 2019. Liz has dramatically reversed every biomarker of aging she’s been tested for because she is the first person to have a telomerase gene therapy and was the sixth person to have a myostatin inhibitor gene therapy on September 15, 2015 in Bogota, Columbia. Liz had to do these treatments in Columbia because it's illegal in almost every country sadly. Gene therapy is the best way to extend human healthspan and lifespan. Gene therapy is expensive though. It currently costs about $150,000 for a telomerase gene therapy which is why I haven't done it yet.

[@agatap4450]

Dr Sinclair keep up your brilliant research!

[@sleepsmartsmashstress740]

He is wasting time. Human life span is starting to shrink, esp in the USA

[@pilarbrache2835]

Fabulous podcast with Dr. Sinclair and Dr. Hyman. Such exciting research!

[@scottgibson92]

Great content! Thanks, Dr. Hyman!

[@heidisunshine2003]

Great conversation 🌻 I enjoyed listening.

[@rachidaken7482]

Verrrrry much interesting .....thank you very much......go a head in your search .......

[@jimmyezra5451]

Imressive..whether it works or not. for sure a step forward ...Hyman, Sinclair, Longo, Panda, Patrick and 5 others are amagzingresearchers that should be appreciated by all...

[@kathleenousey8938]

Jimmy Ezra You’re right! And the people you mentioned show me that you know your stuff!

[@jheichelbech]

Ah, Fries Compression of Morbidity. Love that paper. Thanks for mentioning it.

[@soapcake1]

also what type of R-alpha-lipoic-acid and how much daily?

[@kaininjapoke1hero81]

Death is not inevitable.

[@jewelleryaddict]

So interesting. I came down with chronic fatigue syndrome after being exceptionally well serving in our Air Force. At 38 about time of Incline village outbreak. Fatigue was crushing. So started college trying to cure myself because no one was helping me. First human biology class relearned about mitochondria again. Bingo there was my cure I thought asked my professor how do I increase my ATP he had no answer in 1985. So began my dive into fixing myself. My next question was how can I reverse why happened to me and how do I undo this. Skip to now suppliments have done more for me than any doctor ever did., they say you can take all that and pee it out. Anyhow My energy is fairly well and I am much older but at 70 husband and myself take no drugs eat well And take about 20 suppliments I research by university studies mostly. I did get a paper published in medical journal. Journal of Neuromuscular Pain in 2000. Am a lay person after 2 degrees. Don't want live forever just live well while I am here. Love that mitochondria.! And go ATP! I take most suppliments you both mention they help, husband too. Not young again but for age pretty good. Keep researching

[@Venus.actor.singer]

Adam from the bible died at the age of 930 years old and his descendants died at the age of 800 to 700 to 600, etc and Joseph died at the age of 110 years old. So Dr. Sinclair is helping us live longer the way God created us to live. Sugar and the poluted world is making us live shorter.

[@sunnifreyer2759]

@James George I do not take the Bible literally but when I read the end of his statement, I thought OK..if that is the path he needs to take to get him to embrace Sinclair's research, I'll live with it. I disagree with the years lived part of his sentence but it's OK, let it be, if he listens to the research, that's a good thing.

[@niagregory2656]

Im aiming to look 15 years younger . I won't accept 1 wrinkle until after my first child.

[@stevennoren8922]

Lost me on the plants but still agree with 90% but you can't agree with everything in life this creates balance. I started with Keto now switched to carnivore started very unhealthy at 62 years old 268 lbs now 147 lbs and reversed much of my ailments. It's all experimental. on your own body I'm happy so far.

[@ryummon]

I was very impressed with everything he was saying, then he goes and says he's worried about his 200+ cholesterol and taking statins for it, and I just felt the urge to trow him out of a window...

[@bennguyen1313]

Would love to hear David's homemade yogurt recipe, as well as the one he buys (51m10s)? I wonder if it's the same recipe that Ken Ford and William Davis use, that contains Lactobacillus reuteri (ATCC PTA 6475 and DSM 17938 strains). You can get those bugs in BioGaia's Gastrus. Regarding the insulin mimetic R-alpha-lipoic-acid (53m), any recommended brand? Doctor’s Best Stabilized? Solaray Acetyl L-Carnitine ALA?

[@rhyothemisprinceps1617]

He uses Bravo starter culture and full fat milk.

[@rhyothemisprinceps1617]

If you haven't taken ALCAR or R-ALA before, I would first try stand alone supplements, not in combination. ALCAR can cause headaches; it did for me at first. I lowered the dose by only taking part of the capsule and slowly ramped up to 500 mg on an empty stomach. I can't take R-ALA at all since it causes me to have hypoglycemia attacks; I may try again in future, though.

[@fingersm]

He needs to go on Joey Diaz podcast!

[@kathyowens890]

Great podcast!

[@laurabarrett5286]

Please tell me about the rings that collected data you both are wearing & who processes the information collected?

[@creepycreepy4902]

Laura Barrett oura ring

[@integra8502]

Which NAD to buy?

[@omidalizadeh9868]

Please have Dr. Rhonda Patrick on the show

[@GregAshby]

Yes, Dr Rhonda

[@howardhooper4383]

Can you let me knowthe yogurt product Dr Sinclair is eating in the morning with his reservatrol ?

[@StopClimateEngineering]

He makes his own, according to some other videos like the JRE podcasts

[@ethimself5064]

Yogurt, I believe

[@rhyothemisprinceps1617]

He uses Bravo starter culture and full fat milk.

[@howardhooper4383]

Thank you Rhyothemis

[@keithcorodimas8093]

@@rhyothemisprinceps1617 Yes, this is correct. Thanks

[@insideoutbeauty3170]

Thank you for this amzing conversation. Wish he could trade the statins for high doses of Turmeric and Garlic . Wishing you both the best XX

[@suzieqwonder3089]

Sinclair definitely looks A LOT YOUNGER than 50 yrs old!

[@mobutter2879]

Only, he's diseased.. no one naturally has high blood sugar. He's all about artificial cures, not cause or prevention. Metformin, eats your kidneys..

[@lylan8737]

Can u tell us what yugart he is eating

[@silglo]

Which is the cocktail for mitocondria?

[@ayshaatman8857]

Thank you

[@mart7379]

David Sinclair is nothing short of genius and gift to humanity in my opinion (and from my research). Thank you Dr Mark your show is inspiration to many. I wonder what both your thoughts are on what is also an emerging science, the role our thoughts, feelings / emotions and beliefs play in regulating gene expression / health? These 2 theories combined (how to enhance the mechanical body for optimum performance and health and longevity) coupled with how to ‘consciously’ (I use that word very purposefully) pursue health choices, seems to me to be progressional evolutionary path?. Exciting time to be alive. Very grateful for your work.

[@kathleensmith8969]

Martin Smith I so agree! Health was great until four years. Last few years so many negative thoughts and feeling defeated. Never been in as poor health.

[@soapcake1]

Can someone please tell me where to buy the resveratrol in powder? he just said the tha capsules wont absord and im already taking thoose :(

[@rhyothemisprinceps1617]

You could just open the capsule and mix into something (it tastes bitter though); or buy from Bulk Supplements on Amazon.

[@carolwong9279]

Very interesting, but a bit concerning to take Metformin. Ellsworth Wareham worked as a CV surgeon til he was 96 and died peacefully at 104. I think I will follow his lifestyle of eating a plant based diet.

[@divine4454]

Take berberine instead, I'd say it's better. Wonder why he didn't say anything about it, I might ask in email personally :) there's a lot of studies that show berberine as strong as Metformin without side effects or even more positive effects.

[@georgesmirnoff9751]

David Sinclair PHD, a troublemaker we can all be proud of! I'm a fan! Go David! Vera would be so proud! But hurry up! We're not getting any younger you know! ; )

[@JA-js5gi]

Curious!! What type of rings are you guys wearing?

[@isaacuselman7592]

ouraring.com/why-sleep-matters/

[@JA-js5gi]

Thank you guys!!

[@sheilaeddison5488]

high 200's soooo not an issue, how are your trigs? have you done CAC?

[@FatherGorgony]

Good interrogation 😆

[@bobdylan2843]

If you don't die from aging, do you just wait to die in a horrible accident?? LOL

[@VtRD]

I keep reading about fasting, and it's mentioned here as well. I don't see that as sustainable for most people. What is more alarming to me is how much low-quality food and drinks people consume in the US, and lack of cooking skills.

[@StopClimateEngineering]

Why do you think fasting isn't sustainable for most people?

[@SCIENCEnENGINEER]

@@StopClimateEngineering they can't even resist the temptation of a dang nasty drug/cigarette/beer can. You really think they can go abstinent with food???? 🙄 Hell no

[@jerrycadena2024]

Dr. David is just lucky to have good genes- his dad George Hamilton never seemed to age either.

[@spoofsatire4328]

Know his lifestyle & he was the first receipent of all his researched molecules. Hence so

[@fzesgru]

Dr Sinclair is too pharmacologically oriented for my taste. Why not use the precautionary principle and start with the natural mechanisms (diet, exercise) that increase telomere length and reverse aging by first reversing the chronic metabolic diseases that are healthy life span destructive. Net influence on health of drugs like metformin should be clinically evaluated with subjects that have already achieved baseline resilience via natural mechanisms. Otherwise we're just putting toxins on top of toxins...confounders on confounders...what the heck does that tell us? Dr. Sinclair mentions early that teenagers don't get cancer. I'm sure Dr. Sinclair must be aware rates of cancers in the young (developed world) are in an exponential progression, and the number of cancer hospitals for children is also. Let's ask what Dr. Alan Goldhamer (TrueNorth Health) is doing to look so young for his age...pretty sure metformin is not going to be on that list.

[@ValerieHarristhefoodiemedic]

Very interesting - So, I noticed that vets us antioxidants and vitamins emergently in very ill animals. I'm thinking that a more natural approach has been undervalued.

[@stevennoren8922]

Amazing information I did it though diet. Keto

[@orenschulman4554]

Can I drink black tea while fasting or does this act to cancel the fast? Thank you!

[@Rafas216]

That cancel the fast. Rhonda Patrick talk about that. Sorry for the bad english

[@gipgap4]

Rafael yes, anything you have to digest breaks the fasting state.

[@SCIENCEnENGINEER]

For insulin/glucose fast, no. For other types of fasting, dunno.

[@cabolynn]

Look into the work of researcher Doris Loh, who will be co-authoring a new book on anti aging and longevity, world wide in April of 2020. I'm currently part of one of her amazing anti aging experiments which she will be writing about in her new book. I'm just shy of 60 years young. Merformin is a double edge sword and should not be taken by anyone with a poor REDOX potential.

[@starflower666]

what about niacin instead of statins and berberine instead of metformin

[@szymon52]

Although I am obviously not David himself, if that’s whom you were asking, I would like to point out that the drugs you’ve listed are not fully interchangeable and/or equipotent. A big part of the niacin MOA (i.e. mechanism of action) relies on activation of the so-called niacin receptors. On the other hand, statins function as inhibitors of an enzyme that leads to cholesterol production, namely HMG-CoA reductase. Metformin and berberine are somewhat alike, given their shared ability to activate AMPK; however, metformin has been used and studied for over half a century, whereas berberine is relatively understudied (of course, there’s no real incentive for pharmaceutical companies, especially since metformin has such an amazing safety profile and is so cheap). For instance, berberine has been reported to inhibit cytochromes P450, so it could affect metabolism of drugs and lead to their elevated blood levels. My point is, if you want to have the benefits of metformin, I’d personally try to get metformin. Either way, » use the right tool for the job «, and know what you’re doing. And consult your doctor, particularly if you plan to combine various drugs, or e.g. you’re taking a statin and trying to replace it with niacin unsupervised. Take care.

[@starflower666]

@@szymon52 I dont have cholesterol or blood sugar problems. I do need a safe easy way to increase my iron though! I dont think meat or supplements are the answer. I havent found a great solution yet! If you have the answer I would be grateful!

[@intrinsicfactor5425]

@@starflower666 .......a Copper deficiency may cause iron deficiency anemia.

[@starflower666]

@@intrinsicfactor5425 thanx! i take a zinc/ copper supplement but I guess I need testing. A vegetarian diet doesnt help either! Maybe I should cut the zinc/ copper supplement and see what happens, but I dont want my thyroid going downhill!

[@calliec611]

Sparleberry zinc competes with the absorption of copper but be careful with copper as too much can do harm. Its very easy to get enough through diet. But like I said be careful, especially if you have slow metabolism or any gut issues

[@jerrycadena2024]

Hey, what about people living to about 120 in the Bible- what about Methuselah?

[@Horizon344]

Mmm, the problem with what Prof. Sinclair is saying with regard to a physical fitness & dietary programme extending natural lifespan is, that I'm not aware of any1 who maintains what he recommends throughout their lives - ex-professional athletes for instance who maintain a healthy physically fit lifestyle into their later years, living any longer than people who don't, they all physiologically conk out generally in their 3 score years & 10 (or 20). I see none of this class of people who are living until they're 130, with the couch potatoes all checking out at 50. Physical fitness & good diet is fine & it may keep you in good shape thru your life, but I see no evidence that it actually expands that life timewise, which is what he's pursuing with his work.

[@goliathonscave9834]

They're not living longer because they have not changed their diet. As a physician, I know of 55 y.o, thin, vegetarian, marathon runners who are having heart attacks. I believe the key is to continue to exercise, get good sleep, and most importantly, maintain a diet that keeps your insulin levels low. I believe Dr. Sinclair's supplement recommendations enhance things even further.

[@mR-dc4oq]

Dr. Sinclair could benefit from having you manage his health. Four hours on Sunday at the gym? To make up for lost gym time? No side effects of metformin? I’m currently looking at Dr. Que Collins’ opinion on supplements- don’t take them. Admittedly I’m just looking at that... I still do supplements. Alpha lipoid acid... good stuff.

[@sheilaeddison5488]

just not sure why Mark needs to be in such a big chair making David look, small... someone needs to be on this!

[@angelarohr2479]

Looks like same chair mark is just closer

[@dakotaknight1572]

Why are you both being so darn vague? We listen to these podcasts for actionable information. What protocol did Dr. Hyman use to recover from his CFS? What are the “and some other stuff” he spoke about in his wife’s protocol? Other than NMN, NR and resverotrol, what other molecules is Sinclair talking about?

[@lisaa6099]

100% agreed, 1 hour and no details given. No one cares about the extended bullshit ego introduction just get to the finer scientific specific details.

[@Nilsosmar]

I'm told that Sinclair's book has more specific information.

[@dakotaknight1572]

Nils from Alaska I downloaded his book yesterday and I’m 110 pages in. 😊

[@SCIENCEnENGINEER]

@@lisaa6099 then move on to the do-this-do-that channels for ignorants, if you can't learn to appreciate the info like others, PLEASE LEAVE!

[@ratherrapid]

quit interrupting the through process.

[@sandycarlyonroubal4898]

Hyperbaric oxygen therapy chamber?

[@DJRS2178]

Lost me at statin and cholesterol

[@jameshasckell6783]

9:28 "If you're a teenager you don't get cancer"... are you serious?

[@jerrycadena2024]

Well generally that is true. The percentage of people over 60 having cancer- I am sure is much higher than the percentage of teenagers. In fact- because teens don't get cancer that much - and because they have their whole life ahead of them- we remember and pity teenagers with cancer and remember those stories better than stories of older people getting cancer. We blow those older people stories off and just chalk it up to it being these older people's time to go.

[@betsyrocks]

I picked up on that. I think he may have mis-spoke

[@jerrycadena2024]

@@lordjim3109 Dear Jim - yes a teenager can get cancer- and that is devastating for the teenager and his or her family- but this video is talking about generalities for the entire population- so something with a low percentage- i.e. low odds of occurring- in the general population- is what is important to illustrate the videos point.

[@JohnnytNatural]

He's talking in general. Even newborns can get cancer. We don't understand why. Obviously, it's not age related for these individuals, something went wrong: a virus, a mutation, a defect, who knows. But in general, cancer is a byproduct of age when your body fail to repair itself. That's the point he is making.

[@SCIENCEnENGINEER]

If you don't take everything literally without logic, and simply understand it as: teenagers don't just die of natural causes (unless being in accidents), you probably can enjoy the day a bit longer!

[@MrSimonious]

Sugar. Period.

[@AsmaaEltigani]

How many supplements does Dr.Hyman take 😂

[@acceleratefaster46]

You can delay but cannot escape death.Its inevitable.It will always be around the corners.

[@jeffhresan2886]

Dr. Sinclair, LifeVantage is getting ready to release a product that has been shown to increase sirtuins by 100% in 24 hours. Would this be something that you think might have merit?

[@ultimatebjj]

What makes me question Sinclair’s overall intelligence is the fact that he espouses the importance of higher NAD levels systemically through out the body, yet he does very little outside of taking meds and NMN to accomplish this. He could easily go off the Metformin and high levels of statins by following a well formulated ketogenic diet. I’ve heard him mention that he realizes the importance of keeping carbohydrates low for overall health, but uses the excuse that it’s difficult for him to do because he has children. He seems to just be looking for the free easy ride home. To the point, I have seen very little if any compelling evidence that NMN or Resveratrol do anything at all to extend out the years in any human or primate. Metformin has shown some promise in research. Metformin coupled with a well formulated ketogenic diet is probably at the top of the list of things we can do to extend our years. Sinclair needs to realize that he is already metabolically compromised from his dietary habits (hence the statins). Taking all those compounds is probably still netting him into the negative. You literally can not have your cake and eat it too!

[@JATSon-bi6xx]

Why not the day has surely come to understand and use that understanding to our benefit.

[@SCIENCEnENGINEER]

Please stop the freaking KETO hype bull crap. Take it elsewhere! to your lovely advocates such as Mr Berg's channel, you don't need to see this video, bye!

[@ultimatebjj]

@@SCIENCEnENGINEER Look at yourself in the mirror bud, probably not a pretty picture. More importantly, take a look at your health markers, probably not much better. No further comment necessary. BTW, you don’t control the internet. You don’t get to control what I or anyone else thinks, writes or expresses. Got it?

[@angelarohr2479]

Right!!

[@nks487]

I have to just note how expensive these regimens are! I take many of the mentioned compounds. Probably costs me around £100/month. That's really not affordable for majority of people! :-(

[@blackmartini7684]

For the moment, once they become more common use the price will drop like traditional vitamins. In fact NMN is just another form of vitamin B3.

[@ngaichingtouthang1679]

@@blackmartini7684 nice advice so i ll take vitb3 ok

[@SCIENCEnENGINEER]

How much do you make in a freaking month?? That is expensive?? For your health? Wtf you use the rest of the money for? Nice cars, nice Clothings? Then perhaps you should really get a smaller house/apt to pay less tax/rent so that you afford some real crap!

[@somchai9033]

Rumor has it Dave Sinclair is a vampire.

[@douglasmontgomery6315]

Dr. Sinclair lost cred with me when he said ho took statins for cholesterol

[@ektxm]

Don't throw out the baby with the bath water. If you stopped getting information from people that aren't perfect then you better not liisten to anyone and please don't listen to yourself.

[@mpoharper]

He has hyper cholesterol. There are people who may need statins, just not all of us like big pharmaceutical wants.

[@douglasmontgomery6315]

Mary Harper , he mentioned a cholesterol number of 200. That doesn’t appear to be hypercholesterol. Even Dr. Hyman made some comments after he mentioned statins. The latest research does not support statins reducing all cause mortality. Lastly, the chains it breaks in the body, along with the permanent muscle damage outweigh any perceived benefit. Inflammation blood markers and regular CAC scans would be better for him.

[@douglasmontgomery6315]

ektxm , I didn’t say his info didn’t have some potential, just that someone of his knowledge ought to know better than taking a statin. See my comment above.

[@mpoharper]

Douglas Montgomery I certainly avoid them like the plague.

[@isaacuselman7592]

The ring they are talking about: ouraring.com Diagnostic Blood Tracker: www.insidetracker.com/

[@dakotaknight1572]

It is disappointing that Sinclair is going the “pharmaceutical” route with NMN.

[@szymon52]

Why? It’s certainly the proper route for pharmaceuticals meant to be used potentially by tens, or hundreds of millions of people, in the long run... Check the story of thalidomide.

[@dakotaknight1572]

AMP-activated protein kinase I am not saying FDA process is not important although it could be made more efficient and less profit driven. It’s the time it takes to get through FDA approvals and the cost which drives up treatment cost. No one wants another thilodimide tragedy but take for example Navacims. A potential cure for most autoimmune diseases that could literally eradicate the suffering of millions. It was discovered 15 YEARS AGO and just now going through human clinical trials. Just this year, it has been individually licensed to two companies for nearly $1 Billion each license for the development of just a few of the most profitable (diabetes, IBD, and arthritis). Meanwhile many other devastating autoimmune diseases like MS, Lupus, and about a hundred more are waiting for another company to step up and pay the next billion dollar licensing fee to develop their drug on this ground breaking platform. I reiterate that this is not being researched as just another treatment but an outright cure. It will probably be another 5 years before even the first drug hits the market. It shouldn’t take 20 years for a drug to come to market. That’s 20 years of unnecessary suffering and death. FDA process is necessary for platforms like Navacims but why take something that is basically a form of vitamin B3 (niacin) that is only patentable because of how it’s produced through an extensive FDA process?

[@blackmartini7684]

@@dakotaknight1572 It won't take 20 years you can purchase NMN now and try it yourself. Also if you actually read his book this is a small fraction of what he's working on to combat aging. They're also looking into gene therapy, specifically the gene editing that reverts cells into stem cells, he's been able to dial it back in mice that they don't become tumors. The exciting part is that not only do the cells become healthy again but damaged/severed organs like optical nerves start regenerating.

[@dakotaknight1572]

BlackMartini I have read his book. It is really good.

[@theadventuresoftaco7306]

Tackling heart disease and cancer!!??? More like a lot of missed tackles!!

[@Rafas216]

What he Said at 53:33?

[@JohnSmith-hq7cb]

How is intermittent farting beneficial?

[@brain6496]

JohnSmith M Plenty of information on the net to explain in detail. Fasting puts the body into repair mode as part of a survival mechanism built into all life on earth by the means of several mechanisms to include activating Sirtuin genes. Google calorie restriction and fasting for longevity. NAD precursors assist the same Sirtuin genes to work at capacity and Sirtuin activators (think plant chemicals) increase their function.

[@MichaelMerritt]

People that believe intermittent farting is beneficial are full of shit.

[@benzhao6321]

Nobody gonna invite you to dinner anymore...😷

[@jcjc3671]

Beneficial because you'll feel better, n not bloated n stressed. Keep it low key though like intermittent silent quiet shots n when people start sniffing n looking around, do exactly the same.

[@rhyothemisprinceps1617]

I find it helpful; when Trade Joe's is crowded I can get closer to the produce shelf faster.

[@starflower666]

what is the yogurt he likes?

[@IberianAmerican]

Bravo brand is what he said in another video.

[@starflower666]

@@IberianAmerican Thanks!

[@vicwahbyphotography4866]

Also, just learned the depths of Dr. Sinclair financial interests in age defying products. Conflict of interest anyone? Wow. Any wonder why he's on all the pop-shows BEFORE human trials? We all WANT to believe. And who knows ... Some of his N=1 studies may prove valid. Meanwhile, buyer beware.

[@samrl1170]

Just image someone trying to profit from their own hard work... how dare he.

[@vicwahbyphotography4866]

@@samrl1170 If he declared his financial interest early in explaining the wonders of the products he sells, there would be no conflict of interest. He doesn’t do that.

[@samrl1170]

@@vicwahbyphotography4866 I have seen plenty of videos where he discloses that he has helped developed or works as an adviser for companies and products that sponsor him.

[@vicwahbyphotography4866]

What did doctor Sinclair do that brought his tested biological age to 31.4? So much joking and interruption that this key bit of information was never clearly stated. Incredible.

[@Leadbellie]

NAD and Metformin

[@davidivers9295]

Actually, NMN or NR and Metformin

[@rhyothemisprinceps1617]

@@davidivers9295 He prefers NMN to NR. He says NR can break down into nicotinamide over time. He also says he doesn't have an interest in NMN, but I wonder about that. (Pretty sure both he and Hyman are getting some sort of incentive to wear their Oura Rings everywhere). Meanwhile there's Nuchido's Time+ which uses nicotinamide in combination with other stuff (parsley/apigenin, rutin, etc); they claim it can boost intracellular NAD+ much better.

[@spoofsatire4328]

Genetic tests

[@HkFinn83]

@@rhyothemisprinceps1617 so since this interview Sinclair and his company have successfully lobbied the FDA to ban the sale of NMN as a supplement due to alleged ‘research for use as a patentable drug’. I believe he’s a credible researcher in some senses but he’s also a businessman.

[@davwht9]

Amplified Bible Listen very carefully, I tell you a mystery [a secret truth decreed by God and previously hidden, but now revealed]; we will not all sleep [in death], but we will all be [completely] changed [wondrously transformed], ◄ 1 Corinthians 15:51 ► Free will blessings. Liberty. Choice. Graces. Those who choose Heaven. And eternal life. Or. Those who choose death. Gifting. Faithfulness and truth. L😍VES. Celebration. Worship is based on values. Fellowship sweet. Blessing to Uwenzez All. 💕💓💜💗💛💙💏👭👬👪🤔🤔🏪😄💛💜

[@mindvoyager2476]

whats wrong with this picture: dr Sinclair exercises 1x/wk 4hrs on Sunday; takes metformin and statins; does not get enough protein for a person his age, sits a a desk all week, advocates caloric restriction in the elderly...heard of sarcopenia?? and last but certainly not least Sinclair teaches at Harvard...only jokin on last item. I do agree with his views on intermittent fasting and feeling hungry for a good part day which I practice and of course the science of aging is fascinating and should be pursued.

[@htaehlane5868]

Questioned much of what they discussed - prefer a more holistic, diet based approach than taking chemicals. When he disclosed that he takes a statin as he is "concerned about his cholesterol"; I turned off the video. Cholesterol is both healing and necessary for our bodies - studies have shown that those with the highest cholesterol levels actually live the longest...

[@lisaa6099]

Heath Braunstein 100% agreed. Statins destroyed my fathers life. You have no idea how toxic that crap is. Thumbs down

[@apaatsio]

> studies have shown that those with the highest cholesterol levels actually live the longest Could you post links to these studies?

[@htaehlane5868]

Here's one link: www.google.com/amp/s/medicalxpress.com/news/2010-09-high-cholesterol-longevity.amp

[@htaehlane5868]

reason.com/2018/09/22/new-research-confirms-we-got-cholesterol/

[@rlenclub]

What worries me about the obsoletion of age is that it means death will be even more feared than it currently is. For example, no matter how well I take care of myself, I will die of old age; death will come to me. However, if aging is no longer a factor, that means that death is completely avoidable (ignoring the fact that the Sun will explode and that nothing can stop entropy). Won't there be people that become so scared of dying that they hide from the world and its many dangers?

[@tomasmuir9812]

True. I would hope that we could just increase healthspan without increasing lifespan, i.e live very well for 100 years and then drop dead quickly.

[@canalroadadventures5079]

Hyman, please stop the jokes and let the visitor talk.

[@FLJD427]

Amen - he is into the social aspects of the interviews since he knows these guys. But it gets distracting when he starts joking and going down rabbit holes. He's got great contacts in his network. Just wish he'd let them free-wheel more and just chill.

[@user-sg7gj5pe1i]

This guy is over 50? Seriously?

[@jerrycadena2024]

Dr Hymen- well yes women can have their hymens sewed back together- to restore virginity and feel younger.

[@apaatsio]

Is that a fart at 24:37?

[@yaquelinllerena9239]

😂 oh my goodness I have to say you have some special ears. Let's hope not.

[@victortorres-iy3ul]

that's him setting his glass down lol

[@dr.mobarakali255]

Both are! That's the Law of the Almighty Creator ... and none can change it!

[@truthseeker9701]

According to everyone who died.. yes.. aging is inevitable!!

[@kaininjathundermmandopoke5167]

aging is NOT inevitable! ( inevitable is overrated I quit in real life,Aging is reversable

[@louiscomadena3230]

​@@kaininjathundermmandopoke5167 I agree With what your saying Aging process is not inevitable He will find a way to reverse the biological aging clock

[@cherylmcduff5388]

Statins and Metformin??? Chromium good for lowering blood sugar. Keto diet great

[@vickybiagini8623]

Whatever he's taking isn't working, he's aged.

[@giuliaiocchi7106]

Dr. Sinclair seems that he uses Botox to keep look younger, nothing against Botox but it seems controversial....

[@Nilsosmar]

His eyebrows move expressively when he talks, and his forehead gets wrinkles when he raises them, suggesting he is not taking botox..

[@michael-qp9xd]

Irratating with Mark Hymann giggling constantly. Nothing really funny.

[@heartofthunder1440]

Ok, death is inevitable. I get it, but aging is not. Why? Because when you die you just come back as a newer you just have to live life all over again. That’s of course if you believe in reincarnation but I know that’s just totally ridiculous.

[@JesusFreakJene]

2 Acknowledgements for Jesus 👏 woohoo

[@laurabarrett5286]

Please tell me about the rings that collected data you both are wearing & who processes the information collected?

[@GAdget-ElWalkmen65-fb5vp]

Death is not inevitable in real life.