Endorphins, Mechanisms of Action, Animation

How endorphins produce pain relief and reward effects in peripheral nerves and the brain. Effects of endorphin on substance P, GABA and dopamine release. Physical exercise and endorphins.
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Voice by : Marty Henne
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Endorphins, for endogenous morphine, are opioids that occur naturally in human body. They are so named because they bind to the same opioid receptors in the nervous system as morphine, and produce morphine-like effects such as pain relief and euphoria.
There are 3 endorphins: alpha-, beta- and gamma-endorphins. All three are short peptides derived from the common precursor protein proopiomelanocortin, POMC. POMC is synthesized in pituitary gland, hypothalamus, medulla and some other tissues outside the brain. Beta-endorphin is most studied and represents the bulk of knowledge we have about endorphins in general.
Endorphins are released in response to a number of stimuli, with the major stimulus being pain. They exert their effects by binding to opioid receptors in both central and peripheral nervous systems.
In peripheral nerves, binding of endorphins, specifically beta-endorphin, to opioid receptors, in particular mu-receptor, prevents the release of substance P, a key factor in transmission of pain signals.
In the brain, the same binding between beta-endorphin and its receptor leads to increased dopamine release. Dopamine is the neurotransmitter that underlies the brain reward pathway. Engaging in enjoyable activities causes dopamine release from dopamine-producing neurons into the synaptic space, where it binds to and stimulates dopamine-receptors on the receiving neuron. This stimulation is believed to produce the pleasurable feelings or rewarding effect. Normally, GABA, another neurotransmitter, inhibits dopamine release in the nucleus accumbens. By binding to receptors on GABA inhibitory neurons, endorphins reduce GABA’s activity, ultimately increase dopamine release and induce pleasurable feelings. Dopamine release in response to pain signals may explain why pain can sometimes feel “good”.
Endorphins are also produced in response to pleasurable activities, meditation, laughter, and vigorous exercise; and these factors have been shown to increase one’s tolerance to pain. Endorphins are thought to contribute to the “runner’s high” sensation, a euphoric state some people experience after intense exercise. They may also underlie “exercise addiction”, in which the brain is desensitized due to repeated and excessive exposures to endorphins; and people keep increasing the amount of exercise in order to achieve the same desired sensation

[@Alilamedicalmedia]

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[@unknownme8246]

I became addicted to these kinda videos...i'm interested in medical field and i'm sure this information is gonna help me in future.🙂

[@mimirhermestrismegistus4585]

That's your endorphins that make you addicted to this knowledge 🙃

[@noban419]

@@mimirhermestrismegistus4585🤬

[@prythal]

@@mimirhermestrismegistus4585and the dopamine of reward after learning it

[@jovanai]

I managed to eliminate extreme period pain with regular intensive exercise. I wish I had learned earlier about endorphins. I am so blown away.

[@Waddlejpg]

Could you tell me more about this?

[@user-di1jq3ks5e]

thank you for a very short and clear description about endorphins mechanism of action and the role of dopamine in positive mood state.

[@starrybenchstudios]

Did not know you could get addicted to exercise...out of all addictions, I’ll go for that rather than porn

[@satrah101]

Exercise hub 😄😜 EH.

[@brucenicholas1999]

im currently in a stage of addiction to the gym best feeling ever 😅

[@ugi062]

I mean endorphin feels better than dopamine to me, it lasts longer

[@p00facee79]

​@ugi062 yeah same

[@kayeblade5948]

Im came here for baki

[@chayennebisschop1032]

Same

[@learners6472]

Same

[@EREN_YEAGER1548]

Same here😂

[@denizibis9214]

Me too

[@mshrk6894]

Im for saitama

[@dev5605]

Thanks you sir 🙏 this video is very helpful 😊

[@aceincarnate2762]

Okay I'm confused. >Alcohol is also a positive GABA modulator, which INCREASES GABA RECEPTOR ACTIVITY. >This video said that GABA inhibits DOPAMINE release. >However, we know that Alcohol, INCREASES DOPAMINE RELEASE. How is it that Alcohol INCREASES GABA ACTIVITY (which inhibits dopamine) and ALSO INCREASES DOPAMINE?

[@Ady00pk]

Alcohol is a substance that makes the brain to get used to it really fast. That's why it's so easy to become an alcoholic. The gaba receptors are stimulated by alcohol just for a short period of time. In perspective , alcohol reduces activity in the Gaba receptors, not increase it.

[@Ady00pk]

If there's a constant supply of alcohol , the brain starts reducing the number of Gaba receptors by adapting to the intake.

[@manifestdestiny9472]

This channel is so amazing thank you

[@Alilamedicalmedia]

Glad you enjoy it!

[@medicalbiochemistry_]

Nice lecture

[@RaJr-oy8ky]

Sooo what I gather from this is that heavy alcohol use triggers a natural pain response in the brain that makes alcohol as addictive as an opiate for some people?????

[@fantasyskeep]

Is this why I laugh uncontrollably when I'm physically injured?

[@mayankmalik8792]

No

[@mayankmalik8792]

That's psychological not biological

[@fantasyskeep]

@mayankmalik8792 That's not an answer. Also, it could be either. I don't believe my reaction personally is psychological.

[@lightbeingpontifex]

Yay for endorphins,,,

[@poopwarrior1930]

i wasnt asking for this i was searching for the software

[@Merrla]

Ion get no euphoria from intense exercise, all I feel is pain 🥹

[@Orbowitz]

Some people just don't get the "runner's high"

[@joeyjoe5810]

@@Orbowitzits because you have to hit a very high heart rate everyday Nd slowly you will feel the euphoria increase at the end of your workouts, proper nutrition is also super key for this to work, hitting protein goal everyday and supplements will help

[@beaverbank9823]

​@@joeyjoe5810facts

[@bhblueberry]

Why there are no endorphins in the form of medicine? Is there a problem with brain-blood barrier?

[@thehandliesthandle]

he mentioned morphine mimicks our bodies natural endorphins, and other prescription painkillers and opiates do the same thing. those drugs do cross the blood brain barrier, and i believe he was saying morphine is literally something our body already produces on its own

[@bhblueberry]

@@thehandliesthandle Yes we have a lot of different substances synthesized in our body. Morphine is even in milk and cheese, it is a very popular substance in nature. But Morphine is an opiate and I've asked about endorphins.

[@prabhsingh8817]

Bro endorphins literally means endogenous(made inside the body) morphine,, and artificially produce morphines can be abused by people and cause bad addiction

[@bhblueberry]

@@prabhsingh8817 Thank you, I didn't knew :)

[@dev5605]

Please make more video

[@judyonstine5363]

Thank-you that was so ln couraging. Is that gland called medulla longgota? Thankyou again.

[@lakshyaverma7227]

I just came bcz of anime grappler baki

[@kinwiggler5489]

lol

[@yusska722]

hahaha samee

[@dedserious8214]

Yea like I just wanted to confirm if what baki's mom said was true or not

[@adityaswarup7811]

Same!!!!! The only anime that made me push my self harder in the gym 😂😂

[@samadhishaq]

So basically get addicted to working out, not dope. Got it.

[@dieplinhnhu1009]

0:49

[@aniketfulari4836]

How many knows Ohma tokito?

[@montazaraldujeili2475]

kingggg konggggh😍😍😍😍

[@ItsGMarty]

Im here cuz hot sauce :)

[@Zaland8606]

Who is here after watching Baki the grappler anime? 😅😅😅

[@shoaibiftikhar710]

So true

[@shoaibiftikhar710]

Just after Gaia fight😂

[@user-vi3hc5id1j]

Agedating

[@Reno_SF]

Do you try and sound like some one that might hit on almost smart people?