HEATED Insulin Debate, Should You Use It? Mitochondrial Efficiency, SLU-PP-322 Magic For Fat Loss?

[@VigorousSteve]

Workout With Dr. Dean St.Mart @ Binous1 Gym: kzbin.info/www/bejne/nKvQp2mmZ7SCfs0 Electron Transport Chain: kzbin.info/www/bejne/goLQhX6ufpmKpJY Ubiquinol: www.iherb.com/pr/now-foods-ubiquinol-100-mg-120-softgels/57583?rcode=DTV967 PQQ: www.iherb.com/pr/california-gold-nutrition-pqq-20-mg-30-veggie-softgels/86595?rcode=DTV967 Folate: www.iherb.com/pr/now-foods-methyl-folate-1-000-mcg-90-tablets/70964?rcode=DTV967 5% Discount Code: DTV967 Groennebaek, T. et al. (September 15, 2017) Impact of Resistance Training on Skeletal Muscle Mitochondrial Biogenesis, Content, and Function. Frontiers in Physiology, 8:713. doi: 10.3389/fphys.2017.00713 pismin.com/10.3389/fphys.2017.00713 Porter, C. et al. (September, 2015) Resistance Exercise Training Alters Mitochondrial Function in Human Skeletal Muscle. Medicine & Science in Sports & Exercise, 47(9):1922-31. doi: 10.1249/MSS.0000000000000605 pismin.com/10.1249/mss.0000000000000605 Liu, M. et al. (August 24, 2022) Mitochondrial dysfunction in heart failure and its therapeutic implications. Frontiers in Cardiovascular Medicine, 9:945142. doi: 10.3389/fcvm.2022.945142 www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.945142/full Billon, C. et al. (September 22, 2023) A Synthetic ERR Agonist Alleviates Metabolic Syndrome. Drug Discovery and Translational Medicine, JPET-AR-2023-001733; doi: 10.1124/jpet.123.001733 jpet.aspetjournals.org/content/jpet/early/2023/09/22/jpet.123.001733.full.pdf Nasri, H. (2024) New hopes on “SLU-PP-332” as an effective agent for weight loss with indirect kidney protection efficacy; a nephrology point of view. Journal of Renal Endocrinology, 10:e25143. doi: 10.34172/jre.2024.25143 www.jrenendo.com/PDF/jre-10-e25143.pdf ✅ Follow Kurt Havens Here: KZbin: @kurt.havens Instagram: instagram.com/kurt.havens/ Website: www.atomiclifecoaching.com/ GH eBook: www.atomiclifecoaching.com/store/p/ebook-the-science-of-hgh Anabolic eCourse with Paul Barnett: www.anabolicbodybuilding.com/the-science-of-anabolics-performance-enhancing-drugs ✅ Follow Dr. Dean St. Mart Here: KZbin: @Deanstm Instagram: instagram.com/deanstm/ SN Education Website: www.sneducation.co.uk/ SN Education Instagram: instagram.com/supplement_needs/ Atlas Laboratories Labs Website: www.atlaslaboratories.co.uk Atlas Laboratories Instagram: instagram.com/atlas.laboratories ✅ Follow Vigorous Steve Here: Website: vigoroussteve.com/ Consultations: vigoroussteve.com/consultations/ Advice By Email: vigoroussteve.com/personalized-advice-by-email/ eBooks: vigoroussteve.com/shop/ KZbin Channel: kzbin.info KZbin Memberships: kzbin.infojoin Patreon Memberships: www.patreon.com/vigoroussteve Clips Channel: www.youtube.com/@vigorousclips Instagram: instagram.com/vigoroussteve/ PodBean: vigoroussteve.podbean.com/ Spotify: open.spotify.com/show/2wR0XWY00qLq9K7tlvJ000 Apple Podcast: podcasts.apple.com/us/podcast/vigorous-steve-podcast/id1699523557 Reddit: www.reddit.com/r/VigorousSteve/ 🦍 Gorilla Mind (Mode, Nitric, Smooth, Energy, Turkesterone, etc.) 10% Discount Code: VIGOROUS Affiliate Link: gorillamind.com/vigorous 🐘 Intelligent Shop (Fragrances, Ketoconazole & Minoxidil Shampoo) 10% Discount Code: VIGOROUS Affiliate Link: intelligent.shop/vigorous 👨‍⚕ Marek Health (Comprehensive Blood Work Analysis & Professional Medical Guidance) 10% Discount On Your First Comprehensive Vigorous Panel & Additional Markers: VIGOROUS Affiliate Link: marekhealth.com/vigorous 🥤 iHerb (OTC Health Supplements) 5% Discount Code: DTV967 Affiliate Link: www.iherb.com/?rcode=DTV967 🏥 Essential Health Monitoring Devices: RENPHO Digital Bluetooth Body Weight Scale: amzn.to/37p5O2E OMRON 7 Series Wireless Wrist Blood Pressure Monitor: amzn.to/3udI3n7 KETO-MOJO GK+ Bluetooth Glucose & Ketone Testing Kit: amzn.to/3NLsJG5 KETO-MOJO GK+ 60x Blood Glucose + 60x Blood Ketone Testing Strips Combo Pack: amzn.to/3LK3ylf KETOSCAN Mini Breath Ketone Meter: amzn.to/36QOB29 BRAUN ThermoScan 7 Digital Ear Thermometer: amzn.to/3KfvWeP EMAY Digital Sleep Oxygen Monitor: amzn.to/45RG4FN FITBIT Charge 5 Advanced Fitness, Stress, Sleep & Health Tracker: amzn.to/3LDU2Qy ⚕ Vigorous Amazon Store (Bodybuilding Health Stuff): Website: www.amazon.com/shop/vigoroussteve 🙏 Did A Video Change Your Life For The Better? Feel Free To Donate! Credit Card: vigoroussteve.com/product/appreciation-or-donation/ Bitcoin (BTC): bc1qy79kvq4vupfv90qs0nudpq7k8w6z3jx39ytnp0

[@alvarojdc100]

0:00:00 - Intro Teaser 0:01:19 - Anabolic Round Table - Episode 3 Begins! Dr. Dean Is 3 Days Out 0:02:03 - Thoughts On Meeting Dean In Real Life 0:02:59 - The Bros Will Have A Booth At The Mr. Olympia! + Steve Will Be Speaking At The Olympia University 0:05:01 - Thoughts On Big Paul Winning His Pro Card 0:05:50 - How Can Dr. Dean Stay On Diet During Vacation In Dubai? 0:07:21 - Steve Let Go Of His Diet After Training With Wesley 0:08:58 - Kurt Can’t Get Fat! 0:09:44 - Travelling Gets Tougher The Older You Are + Benefits Of Business Class 0:11:33 - How Much Does Steve Weigh? + Thoughts On Chase At 290 Pounds 0:13:13 - Steve Started His Mr. Olympia Cycle! 0:14:22 - Steve Will Stop Taking HGH 1 Week Before Travelling 0:15:44 - How Much Is The Most HGH Steve Has Used? 0:17:39 - Thoughts On Dr. Deans Competitions 0:19:47 - Benefits Of Low Oxidative Stress & Mitochondrial Efficiency 0:21:23 - Dr. Deans Experience With SLU-PP-332 0:24:58 - Dr. Dean Has Never Experienced A Climate Like In Dubai 0:27:21 - SLU-PP-332 Is Still In Research 0:28:00 - Importance Of Optimizing Mitochondria In The Body 0:30:59 - PQQ & CoQ10 Aid In Mitochondrial Function 0:32:34 - Thoughts On MOTS-c 0:34:06 - Steve Has Been At The Forefront Of Mitochondrial Support! 0:34:53 - Importance Of Increasing Mitochondria While Lowering Oxidative Stress 0:36:47 - Benefits For Bodybuilders To Optimize Mitochondrial Function 0:40:03 - What Are The Causes Of Cognitive Impairment While On Prep? 0:44:21 - The Next 5 Year Of The Fitness Industry Will Be About Optimizing Mitochondrial Health 0:46:39 - Mental Benefits Of Daily Fasted Cardio 0:49:50 - Importance Of Having A Priority Matrix For Your Business 0:54:24 - How Steve Structures His Day 0:55:29 - Steve’s Experience With 5mg SS-31 A Day 0:56:39 - What Are The Uses Of Methylene Blue? 0:59:30 - There’s A Lot Of Kratom Addiction In The US 0:59:57 - Dr. Deans Methylene Blue Protocol 1:02:36 - Dean’s Experience With Dihexa 1:03:45 - What Is The Toxic Dose Of Methylene Blue? 1:05:09 - Importance Of Backing Up Your Bodybuilding Knowledge With A Great Physique 1:07:40 - John Jewett Makes Everyone Look Small! 1:08:59 - Will Dr. Dean Experiment With SS-31? 1:10:52 - Importance Of Of Low Oxidative Stress & Mitochondrial Efficiency Post Heart Attack 1:11:41 - How Can You Reduce The Process Of Aging? 1:13:27 - Muscle Mass & It’s Relation With Aging 1:18:10 - Healthy Mitochondria Can Improve The Outcome Of Surgeries Or Infections 1:19:55 - Kurt’s Stance On Exogenous Insulin - Who Can Benefit From Insulin? 1:22:04 - Thoughts On Beta-Blockers To Reduce Calorie Demand 1:23:28 - People Shouldn’t Use Insulin Prophylactically 1:25:00 - Reasons Why Steve Likes Insulin - Sinergy Between AAS’, HGH & Insulin 1:28:28 - Insulin Should Be Used In A Needs basis 1:30:52 - Has Kurt Ever Needed To Use Insulin? 1:31:39 - Dr. Deans Thoughts On Using Exogenous Insulin 1:33:51 - Dr. Dean Does NOT Recommend Insulin Use Before Training Legs! 1:36:13 - Reasons Why Insulin Shouldn’t Be Used During Prep 1:37:28 - Benefits Of Filling Out A Few Days Out 1:39:20 - How Dr. Dean Peaked For His Last Show 1:40:38 - Benefits Of Having A Small Amount Of Sodium Before The Stage 1:45:23 - There’s No Real Need To Eat On Show Day 1:46:03 - Women With PCOS Could Benefit From Long Acting Insulin 1:48:08 - HOMA-IR Score Tests Insulin Resistance + How To Increase Insulin Sensitivity 1:51:11 - Assessing Insulin Resistance Is Specific To Each Individual 1:52:11 - Summarizing Who Can Really Benefit From Using Exogenous Insulin 1:54:05 - Importance Of Really Understanding Fast Acting Insulin 1:56:37 - Thoughts On Bikini Girls Using Injectable Carnitine With Insulin Before Fasted Cardio 1:58:06 - Dean’s Peak Body Weight Whie Using Exogenous Insulin 2:01:11 - Importance Of Lowering Weight & Slowing The Tempo 2:04:54 - Sometimes You Need To Experiment With PED Doses, Weights & Even Women! 2:06:13 - Steve’s Experience With Mirabegron (Beta 3 Receptor Agonist) 2:11:44 - Wrapping Up! Where To Find Kurt Havens & Dr. Dean St Mart!

[@testxer]

This is the absolute best info on ped use... by far!! Love how you guys make it a health first program... too many people think this lifestyle is a drugs first protocol... thanks for keeping it real fellas.

[@bevnae]

Incredibly valuable info shared here. This really is cutting edge and unbelievably underrated. We appreciate you guys.

[@schleybailey]

SLU-PP-332 has been on my radar for awhile now. I've been watching people's experience reports with lots of excitement and seeing how the bodybuilding guys use it is gonna be cool. I think this drug has some real promise.

[@Bigbennichols]

Where are u seeing ppls reports on it??

[@mattepton5731]

Good to be geeking out about some of my favorite topics with Coach Steve, Dr. Dean , and Coach Kurt ! I really appreciate your time and energy in producing this collaboration, they bring a special joy to my life 🙏💯🙌

[@James-mg7fd]

Has to be my favourite roundtable crew. Many cheers!!

[@lukasz.rytkowski]

I fully recommend SLU - been a game changer for me. 15kgs loss while keeping all my strength

[@Haggelus]

What kind of dosage you are using?

[@lukasz.rytkowski]

@@Haggelus200mcg a day

[@kiddfamilyfarmllc9962]

@@Haggelusyes?

[@lukasz.rytkowski]

@@Haggelus 200 mcg per day

[@TheXabl0]

@@lukasz.rytkowskihow quickly did you notice the drop in KG?

[@rwsteward10]

Fantastic discussion, thank you all for sharing your knowledge.

[@gymrat8809]

Hey guys. I was waiting for the next part. (Regarding the growth hormone, I could go into the topic of whether it is worth dividing the doses into several parts.) Dean is in pretty good shape 💪

[@jasoncorrick3058]

Love this podcast guys please keep it going

[@quantumfx2677]

Im getting Dr.Adeel Khan follistatin gene therapy next month! At 55 I will be excited to see the results!

[@haido3371]

Love all the pods but this one is particularly interesting

[@Billy_K.]

Lovely content, thanks guys!! Now Steve if you don't mind me asking, could you please in the next podcast with Dean and Kurt discuss about the efficacy of the subc administration of different aas (not only test) in moderate dosages? This will be a good debate since Kurt since is strongly against running gear subc. I find it superb, 0,4ml daily of test+primo went smooth as butter, zero sides or complications.

[@VigorousSteve]

Yeah I wanted to run that past them, I'll add it to the topic list ;)

[@Billy_K.]

@@VigorousSteve awesome Steve, thanks!

[@Kovalser]

I’m a big fan of subQ admin… it ends up in the same place, just the pharmacodynamics are different. With long esters there is no real difference, some short esters ie acetate/proprionate in rapidly dispersing oils like MCT may have an advantage with SubQ admin as it slows down systemic absorption a bit. I inject up to 0.5cc oil with a 31g slin pin without any issue.

[@mrrptube]

Love these, such great vibes and so much knowledge. Appreciate the content 🤝

[@kusjr4388]

Dr dean!!!!!!!😂😂😂cant believe i forgot dr dean,love u giys and cherish the information we get for FREE!!!!!!!!!🎉🎉🎉❤❤❤❤

[@Alexcarrerafit]

I've had great progress with slu-pp-332!

[@johnpenuela7133]

Where did you buy?

[@Alexcarrerafit]

@@johnpenuela7133 AA

[@mag3513]

What’s dosage from liquid bottle?

[@joshm684]

Kurt did NOT help peak Paul for his show. Justin did. Confirmed by Paul. Not sure why he said this.

[@boudkevin89]

I've been running SLU PP 332 for about 3 months. 200 mcg. Tempted to bump to 400 mcg for the remainder of my prep now!

[@smarttrainingnutrition1046]

How’ve your results been?

[@Kovalser]

I have some incoming. Excited to try it. Will be using with Mirabegron, and inj GW510516 & SR9009 (AA cardabolic).

[@mrmacguffin6886]

Yes please, excited already!

[@kevinstorey9877]

I think you guys are absolutely right on the insulin most people have no business touching that good job guys in keeping it real thank you so much for these videos

[@Kovalser]

I use Tirzepatide to blunt my appetite and it gives some insulin boost too… I won’t touch exogenous insulin, but I’m not trying to get massive either.

[@kevykevkevkev]

It’s good to know that methylene blue can cause an issue with opioids.

[@antma1908]

Thanks Stevezilla 🎉

[@domienballegeer5943]

Great podcast !!

[@seanferguson3502]

Sorry mate BPA is not IFBB elite the UKBFF is linked to IFBB elite . So just to set the record straight and not spreading misinformation on your podcasts Steve this is how it is in the UK at the moment. Helen Panther who runs the BPA now broke away from the ukbff to make her own federation so this is where the confusion may of occurred. Great podcast tho keep up the good work 👏

[@user-J250]

I’m completely addicted to Kratom. I use around 30g/day. I think the only reason why I don’t stop is because it has not negatively impacted my life and has virtually no health side effects but I do not like the fact that I am completely dependent on it and have withdrawal symptoms after around 16 hours of not using it.

[@frankr2921]

Kratom is good shit. My buddy just started selling it. Definitely a good option to pain meds. Its not as potent, but it takes the edge off

[@NicolasDiPietro-gd7qo]

Kratom isn’t bad .. but being dependent on it puts a mental strain on living a normal life. Gabapentin and a SNRI (to help with nerve pain and body aches) should help getting off of Kratom. It’s not going to be easy but it’s doable and just believe your mind doesn’t need it. Good luck bro

[@RandyMarsh2211]

​@@frankr2921he tells us he is addicted and you want to Plug Your shit. Dude wtf?

[@1DEADBEEF1]

Been in the same boat as you but decided to quit since I was worried about heavy metals and orher chemicals in it... ive seen weird fibers in mine (looked like a single white hair, not sure if fiberglass or whatever) you will only spot these if you are encapsulating. I quit 3 years ago and still struggle to do any projects or whatever... motovation not comming back, cant see the end goal... did a cycle of 9me-bc to reset my dopamine system but it did not help much.. Ps. Make sure to monitor your prolactin

[@niceguy4928]

You mean 30 grams. It definitely makes me sleep great especially the red. Never tried the green or white how the other effect you.

[@fluffydragon5355]

Guys I am completely natural, and Dr Dean is talking about a hypo response with insulin that I have experienced many times in the workout where I feel like I’m going to throw up all of a sudden, it happens on leg days. How do I identify this?

[@BrendannKellyy]

Hey guys, could there be any competing effects with methylene blue and 5-HTP? I know Steve takes 5-htp usually but wondering if I shouldn't be running both at the same time. Obviously one is in the AM and one in the PM though.

[@Baby-Dont-Hurt-Me-007]

Steve when you had fatty liver did it make you tired/exhausted?

[@VigorousSteve]

No I had a ton of energy, but when I was fasting for all those weeks I felt like spaghettis by the end of it.

[@einsteinx2]

2:07 I swear it doesn’t matter how many times I see them, but I’m always blown away by how friggin huge Steve is in “real life” photos vs on KZbin, especially when he’s standing next to someone. I know they say the camera adds 10 lbs, but I guess for bodybuilders it drops 50 because you look massive man haha

[@calvinboone3539]

Love the podcast gentlemen.

[@lit_warrior...4708]

Heck yea uncle Stephen 🤣🤣

[@user-J250]

Methylene Blue daily at 10mg might be good for those with high hematocrit right?

[@VigorousSteve]

From what I've seen, from 10mg daily onwards it starts to lower Hematocrit in bodybuilders on erythropoietic compounds. The dose might be a lot lower if you don't run EQ or Primo or Anadrol.

[@DBTUNED-CT]

Is it common to need a small amount of insulin on say 4-5iu GH? My fasting insulin was only 6 but bloodsugar was 95. I feel like my pancreas just isn’t keeping up so I’m considering adding in a basal insulin

[@KenE252525]

1:01:30 So this makes me wonder if methylene blue would be good for lowering my excessively high haematocrit? Or could this cause unwanted complications?

[@bigbob21]

I don’t have experience with high hematocrit, so take what you will from a KZbin comment: I keep hearing on bodybuilding forums lately with guys running 1-2, 5g of gear… they all say, just drink more water/hydrate with electrolytes. If you think 1 gallon a day is enough but still having high #? Drink 2. Still not enough? Drink 2.5, etc…. And to drink 1/4-1/2 gallon leading up to your blood test. Fasted doesn’t mean dehydrated.

[@Kovalser]

Naringin can be used to lower Hct too, be aware it can interfere with metabolism of other drugs. Important for those like me where polypharmacy is a way of life.

[@KenE252525]

@@Kovalser Yea, I wouldn't use naringin.

[@rivonommik2113]

Pure gold

[@stepaniss]

Kurt looking fashionable certified fresh aF

[@user-kc1ci8jg2d]

Any thoughts on c60?

[@pursuingtruth13]

Eisenhower Matrix is 🔥

[@matthewjones5109]

I can't find SLU-PP-332

[@ThinkTwice2222]

But if I'm not struggling, how can guys compete about who "is willing to suffer more" ? 😂

[@kusjr4388]

Love you kurt,love u stephaaaahhnn,and dr....hang on..i forgot doc's last name

[@DBTUNED-CT]

I can’t wrap my head around people in the bodybuilding scene promoting Kratom. Couldn’t be any worse of a sellout.

[@VigorousSteve]

It's very addictive and many fall victim to it, it's honestly an appalling epidemic of addiction, and most don't even realize how addictive it is!

[@patriotmusclelabs2831]

​@VigorousSteve I've said this from the beginning. I'm in recovery myself from opiates. Have 7 years sober and I've seen many people struggle with kratom. For someone like me it's extremely dangerous. It may not grab everyone but it's important to educate people that I've you have an addictive personality, krarom will grab you. You will be raising the dose really high and dosing often. Maybe even escalate into stronger drugs from there. Knowledge is power! As always thanks Steve for your hard work in teaching us all about peds and more.

[@stevendonohoe2150]

Great content!

[@bigslick9110]

Sorry, but I have to disagree with the most statements about insulin...First of all, you don't go hypo so easily as you say...I use 6iu of Humalog before training with 250ml of juice which is roughly 30gr of carbs and nothing else intra except EAA...After an hour and a half of training I return home with BG at around 90...I get low sugars only if I do a 20min cardio session and again nothing so dramatic and not less that 70... On the other hand, I have reached 40iu of lantus with 500mg of metformin, and my morning blood sugar never gets lower than 100 and stays around 110 to 120 even though my A1C is 5.4-5.6%...Forgot to mention that I weight 87 kilos and using this amount of insulin...Not need to be 120 to use it...

[@souravguha2731]

Know about Humalog

[@kusjr4388]

Is that Kurt,nose whistling the whole time?

[@ilijamilos_]

algo

[@user-kc1ci8jg2d]

Prussian blue

[@Morphix86]

🎉🎉🎉