Is EVENITY Osteoporosis Treatment Right for You?

Endocrinologist and osteoporosis expert Dr. Janet Rubin of the University North Carolina Medical School explains the osteoporosis medicine Evenity.
-Chapters-
0:00 Introduction
0:13 Disclosure and Conflict of Interest Statement
0:33 Description of EVENITY
1:49 How is EVENITY Delivered?
4:17 Caveats
7:32 EVENITY and Bone Quality
11:10 EVENITY Compared to Tymlos and Forteo
13:23 EVENITY Side Effects
14:26 EVENITY Contraindications
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ABOUT DR. JANET RUBIN, MD
Dr. Janet Rubin is the Sarah Graham Kenan Distinguished Professor and Vice Chair for Research at the Department of Medicine of the University of North Carolina in Chapel Hill. She is also the Professor of Medicine in the Division of Endocrinology and Metabolism, a Joint Professor in Pediatrics and Pharmacology, and Adjunct Professor for Bioengineering.
Dr. Rubin is not only a Professor of Medicine and researcher, she has a busy clinical practice treating patients with osteoporosis.
Dr. Rubin has been investigating bone remodelling for decades. Her particular focus has been on how exercise and mechanical force affects the cell cytoskeleton.
Since 2008 Dr. Rubin has been recognized by her peers as the best Doctor in America.
Medical Disclaimer
All the information, content, and material presented in this video is for informational purposes only. It is not intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider.
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[@margaretmartinpt]

Dr. Janet Rubin, Endocrinologist and Distinguished Professor at the University of North Carolina Medical School, discusses the drug EVENITY.

[@jodywhite8388]

Insurance in my case.

[@msfreedomwatch3983]

I had one injection and had a SERIOUS reaction. I am 57, in great shape, active, healthy, super diet, and I don't do drugs. I've had osteoporosis for many years. After my first Evenity, I woke up at 2AM with extreme shivers, nausea, aches, and I couldn't walk without holding on to the walls. It was HORRIBLE. It finally subsided by 11AM. I'll never do Evenity again. Then my doctor put me on Prolia. I had zero side effects for 5 injections. But now my bones ache, my lower back and hips hurt, I am less flexible, my joints hurt, 2 of my teeth cracked and I had to get them removed. Most doctors don't tell you the possible side effects of these injections so you really need to research before trying them. I wish I never agreed to any injections. Now I'm in the "prolia trap" which I only recently learned about. I've decided to stop all drugs and implement more protein, milk, and K2 to my diet. I go to the gym almost daily and now I'll add more weights and less cardio. It's really sad what millions of women go through when having osteoporosis, but I say a high protein diet (130g per day) and appropriate weight bearing exercises is much better than a $1300.00 synthetic, man made injection with no history or data on the long term adverse reactions that may lie ahead. Use your best judgement and research what other's have reported before being a lab rat.

[@fionad6338]

Yes the side effects of these drugs are horrible. Do way more research bc you take them. My mom has been in horrible pain. My guess is this woman is representing a pharmaceutical company

[@vivian9803]

Thank you for sharing your experience and I’m sorry you had such a rough time. I have just been diagnosed with osteoporosis and do not trust any of these treatments. I am 65, active and eat a healthy diet. If not for the DEXA, I would not know there was anything wrong and I certainly don’t want to induce issues where none exist because of an ill-advised treatment.

[@B33263]

The fact that you have to follow with Prolia or bisphosphonate after a year we are back to square one.

[@mariamarino138]

EXACTLY!!!!

[@vivian9803]

Hopeless

[@janicelaurence6965]

I had really good results. My bone density improved 13.9%- statistically significant. I started Prolia a few weeks after my year of Evenity.

[@Maintain_Decorum]

I appreciate the information. But I’m still reluctant to take it-too many unknowns.

[@wandayonder9772]

National news in Australia tonight warned about the heart attack & stroke risks from taking Evenity. It hasn't been approved here long but we've had several confirmed deaths from Evenity. Our Therapeutic Goods Administration is usually slow to give warnings about drugs it approves, but was quick with Evenity so the risk is serious. The drug will be more restricted and have more warnings.

[@theresa94010]

Thanks for the heads up.

[@rebecasanchez296]

Who decides which drug is best the doctor, the insurance, or the patient?

[@karencox-sz6rw]

The information dr Rubin gives in the videos on drugs is really interesting and useful. It is good to know the pros and cons of the different treatments to make informed choices. Thank you

[@marymonico6062]

Thank you, very hopeful information and loved the quip about wrinkles.

[@margaretmartinpt]

Glad you liked the video.

[@mariamarino138]

If it prevents fractures, why would a femur fracture?

[@user-qj2wt5cs6p]

Well done ✔!!! Nice topic 👍 And beautifully expressed!!!🍓🍒

[@margaretmartinpt]

Thank you.

[@sherris.2402]

Thanks so much for this info....I am due for a bone density again and based on the number if fx I've had in the past four years,(3) assume I have osteoporosis. But I also have a cardiac problem...so I am glad to know that it is something to consider.

[@margaretmartinpt]

Glad it was helpful!

[@trudihelgeson319]

Thank you for all this great information on osteoporosis medications and osteoporosis in general. it’s very hard to find a doctor that wants to talk about osteoporosis and its treatment. I could not even get a referral to a physical therapist after a L3 compression fracture from my primary doc at Kaiser! He says it’s not ligaments or muscles so they don’t refer?? Fracture was caused by coughing with osteoporosis.

[@user-pu9uy2kq6f]

😂 just started Evinity. So far so good. DEXA at -3.8. kind of scarey for first scan. I'm very active but am being careful now when I climb loafers etc. . Hoping I'll be snow sledding in March. Thanks for solidifying my choice to take the shots for a year. I have HBP that's under control with meds. Also hoping the shots aren't bad for any organs. So far the rest of my organs are good. Thank you again for the video. I do trust in you and the Dr.

[@analaurarodriguezgusta9028]

Dear Margaret. I appreciate all your videos. I wonder if you could have a video with wonderful Prof. Janet Rubin talking about AGN1 local osteo-enhancement procedure (LOEP), which I believe there is a clinical trial right now. Thanks, Ana Laura

[@ThuyTran-ci2et]

Hi Margaret, thanks so much for videos with doctor Janet Rubin. They are very helpful in understanding ost. meds. However, if you ever have her on again, can you please ask her this specific question: Is there any evidence/info from her research as to the QUALITY of the bones in taking these meds. She mentioned quality in relation to atypical femur fractures but aside from this concern, are bones actually better from the meds (or do they become brittle overall, even if atypical femur fracture never occurs and a person takes meds for under five years, as in Fosamax). This is a major concern that would so helpful to clarify. Thanks so much !

[@ThuyTran-ci2et]

I asked this because a major concern is these meds build POOR quality bones (brittle), even if DEXA shows improvement.

[@wandayonder9772]

The guest addressed that in the interview. Basically, she poo-poo'd the idea of bone quality being discussed "on social media". She seems to miss the point that we all have a right to consider how long the newly formed bone will last (quality) and how protective it will be (quality). She pushes for people to take it but underplays its limitations and unknowns. It's a new drug and her confidence in it seems premature to me.

[@theresa94010]

@@wandayonder9772 - She is just another one of those doctors who gets excited over new drugs that gets approvals from FDA. Those drug "studies" are funded by manufacturers of drugs. Positive results are more often than not foregone conclusions.

[@fionad6338]

@@ThuyTran-ci2et They build brittle bone. And that causes breakage. There is a new system out there that will replace DEXA. Called REM Bone density snd bone strength are not same thing. Don’t jump on these drugs do as much reading as you can about their dangers. This is a case of cure worse than the disease

[@user-jh8kf4qu1o]

My first shot was on a Monday my left jaw hurt that night. I have RA and my entire body had a really bad flare. My flares feel like I have the flu the body aches are so bad. On Wed following the shot I had a dentist appt. To pull tooth. I told him I got a shot for bones on Monday and I was not sure what happed but my jaw hurt. The Dentist asked me what the shot was for and I told him to fix my bones. And he cancelled our Appt. Right then and said “ I am sorry and we can’t be sure but if we pull your tooth. It may not heal” . I called the Dr that gave me the shot and told him of all these things. He told me to come down the hill so I did. He told me that these things possibly could not possibly happen to me it’s like a 0.1% chance that my jaw would hurt my left leg thigh hurt too but because of my back problems, I blamed it on that, but it’s been about five or six months and my leg still hurts really bad my neck hurts I get headaches every night. And it keeps me awake. My entire body pain has been bad. I blame it all on my back however I’m not sure this is the case anyway, the doctor said just try one more shot and I said OK but I’m gonna have to wait a few months so I waited a couple of months and then I got another shot and everything got really, really bad . And I wonder when it’s all going to go away. I told him that’s it no more. And I will never do do another shot. The Dr. said he wanted me to try prolia I read up on that I will not do that either.

[@tas9898]

Does she have additional thoughts on the use of this drug? The video is two years old. I am curious.

[@kathiejohns1418]

I am very glad for your vids! However,I did not feel comfortable at all with Dr.Rubins explainations! Which only heightened my distrust in the drugs! I come away even more convinced it's better not to go on any of the drugs as they cause more harm then good,once you start you're hooked because if for any reason you go off them you are in worse condition then when you started! No thanks,I'll stick to the natural ways to help-diet & exercise!

[@theresa94010]

I am with you KathieJohns. This is how we get hooked by big Pharma!

[@erincarmack4815]

Thank you for this video. It is very timely for me as my doctor will review my lab results with me in two days and the possibility of Evenity. I wish Dr Rubin had discussed more the necessity to follow Evenity with a bisphosphonate to maintain the gains from it.

[@margaretmartinpt]

You should discuss that question with your physician.

[@debbiesmyth9206]

Hello, I am a 66 year old female who has just moved from osteopenia to osteoporosis in the past 3 months. My Dr wants me to take phosamax (Alendronate) but mother had really bad luck with the side effects from that medication. Are there any more "Natural" remedies that are successful at treating osteoporosis? Thank you, Debbie S.

[@persistente1]

Could you tell us about Forteo treatment

[@deborahachen7214]

Wondering about whether there is updated information now available regarding real world data on Evinity? Any update since 2021? This was such a valuable video. Thank you!❤❤❤

[@wandayonder9772]

It's a relatively new drug with no long term effects as yet recorded. Personally, I avoid the newer drugs, under 7 years in use, where they are still collecting information. Sometimes a drug is withdrawn after the 7 year trial use period, and sometimes there are BIG warnings placed on them as a result of the drug's harms or limitations being recognised over time.

[@theresa94010]

@@wandayonder9772 - very good point.

[@wandayonder9772]

We had an Evenity update in Australia tonight, plastered all over our national news, warning everyone that Evenity has caused deaths from heart attack and strokes in Australia. Its availability is to be more limited and stronger warnings about the risk of death are now mandatory.

[@gymgrl41]

Can you provide the citation for the comparative study that Dr. Rubin discussed? My insurance company has refused a prescription for Evenity stating that it has not been medically proven to be superior to other options such as Forteo, Tymlos, etc. I would like to be able to provide this research to the insurance company as part of my response to the denial. Thank you so much!!

[@margaretmartinpt]

They are available in my blog post: melioguide.com/osteoporosis-treatment/evenity-a-physicians-perspective/

[@patriciablackmon6764]

First, thanks so much for this video. Do you know if Evenity is better than Alendronate and Vit D2? Thanks for your answer. I'm 54 and diagnosed w osteoporosis and thyroid. I've been prescribed Alendronate once a week w vitamin D2.

[@margaretmartinpt]

You should discuss this with your physician since she/he prescribed this approach.

[@persistente1]

I am becoming 60 never fractured but in the last 3 years I lost 7% my endocrinologist recommended forteo but I was scared of daily injection. I suggest myself evenity but now after I heard this presentation I have some concerns because the dr will use only inpeople with fractures not in early 60.

[@juliedavey4680]

Can this be used for mylomea fractures bone damage?

[@janicelaurence6965]

I started my first injection therapy of Evenity yesterday.

[@chrismacdonald4570]

Sorry to intrude. I would be very grateful to learn of your experience with Evenity as a family member has decided to try it. I hope it's all been good.

[@irmaestherhernandeznaveda1225]

Porfavor decirme como evolucionó con Evenity? me lo recomendaron, ojalá y pueda responderme bendiciones

[@cherlgolja5402]

Please check out menopause Dr Barbara Taylor !

[@DeboWorks]

Evenity caused severe bone and joint pain about 3 days after injection and at about 2 weeks. I had three doses and it has done it every time. Very uncomfortable.

[@mariamcabrera6727]

alendronate sodium 10 mg how safe ? side effects?

[@billyebultman4417]

Thank you for this information. My doctor wants me to use this drug. I have had 9 spinal compressed fractures. This helps me have a thorough discussion & get checked out with a cardiologist first. Heart issues run in my family. I have never had any. I am 63. Dexascan shows -3.6.

[@kathiorr8314]

9 compression fractures! I got my first a couple yrs ago - L2 -after lifting a heavy pallet. Couldn’t afford surgery or physical therapy-(awful ins) but I did get a brace that was around a thousand bucks! It hurts so bad after 10 minutes that I have to take it off. Oh, I forgot to mention that I also got three more insufficiency fractures above the L2 about six months ago. What do you do for the pain and I’m so hunched over I can’t stand up straight. It’s as if my upper body weighs too much for me to hold it up.❤

[@dixiecox3128]

I have IV reclast is that bad it was for one year Dixie (Mo)

[@mariamarino138]

What about young women( im 57) who are fracturing?

[@dr.mohammadashrafpal6066]

Does this drug induce ONJ?

[@VikkiSalari]

Did the Professor indicate that bisphosphonates produce good quality bone? I heard her say Evenity created new bone and good quality. What about the quality of a bone produced by a drug like fosamax? It was a little confusing in discussing that part.

[@VikkiSalari]

Anyone can answer that understood the video? 🤷‍♀️

[@barbaraeddings2274]

I have been taking Evenly Injections for7 months. I am 68 years old with severe osteoporosis. Severe, chronic pain in my back top to hips and legs, nerve pain in my hip and legs. I learned I can not have steroid injections and other meds with the osteoporosis.

[@ThaianneCoelho]

Hi, Barbara? Could you, please, tell us how are you now? The medication had good effects? Your osteoporosis is controled? (Sorry my english... I'm from Brazil). Thank you!

[@barbaraeddings2274]

@@ThaianneCoelho Hi The Evenity Injections did great. After a year of 2 each month for a year. When I had the one density test after I finished Evenity was great. Very much improved. I am now on Prolia, One injection every 6 months Hope you get better. It just takes time. Be careful not to fall and bring on more breaks.

[@jinghongzeng9606]

Thank you for the updates. Very useful info.

[@ThaianneCoelho]

@@barbaraeddings2274 Hi, Barbara! Thank you very much for your response. I'm glad you had a improve. It's great!!! Thanks again and I wish you health and happiness!

[@mariamarino138]

It’s a nightmare 😢

[@lori4375]

I took 2 doses of Fosamax, one week apart. I was nauseous and had severe muscle and body pain for about a month. I cannot tolerate it, I think diet and weight bearing exercises might be my only course of action. I am at

[@attop21]

Similar experience with Boniva, it made me very sick

[@terryholliday5394]

I took one dose of Fosomax, I had severe burning abdominal pain that lasted for 2-3 months with no relief with OTC drugs. I was started on a protein pump inhibitor called Protonix, it causes considerable hair loss.

[@vickitoker6582]

​@terryholliday5394 Gosh, I hope you're recovering and feeling better!! Saw 2 doctors now and they're both insisting on Fosamax ( my #'s are like yours). There has to be a better way!! Doing hrs worth of research. Good luck and I wish you good health 😘😇🦴🙏

[@dianelouise3201]

I really need help because have not been on any medication for 3 years. Was on prolia but had lots of problems. Do you know any?

[@suemoreno5217]

I stopped as soon I had a reaction.

[@karent.8245]

Hi Margaret. If one, such as myself, is religious with keeping up with weight bearing exercise, isnt that potentially better than any drug? I'm crossing my fingers...

[@margaretmartinpt]

You should try your best. However, you should listen to Dr Rubin carefully. If she has a patient with very low bone density, a history of fracture and it looks like another fracture is in her future, a drug like EVENITY might be called for.

[@cindylutz7442]

I've been religious with weight bearing exercise, just had a DEXA scan, lumbar t score -4.6, hips -3.3 and -3.5. Not sure if I've had vertebral fractures, but I did break my wrist 3 years ago--no one suggested a bone scan, no one suggested osteoporosis--and I've lost close to 2 inches in height based on my highest height, 1 1/2 inches since...my mid-40s, and 5/8" since May of 2022. I do have Hashimotos, which I think has affected my heart. But man, I exercise, try to eat right, never smoked, rarely drink, thought I was doing what I needed to do. :-/

[@pennyaleo4106]

@@cindylutz7442 The -4.6 is severe osteoporosis. You can do all the right things and still have osteoporosis.

[@golf4funjn532]

Why isn't this being made available to men? 😞

[@margaretmartinpt]

I asked Dr. Rubin that question and it is discussed here: melioguide.com/osteoporosis-treatment/evenity-a-physicians-perspective/#EVENITY_and_Men_with_Osteoporosis

[@golf4funjn532]

@@margaretmartinpt Thank you