New Research: Is Keto Beneficial for Heart Health? | Educational Video | Biolayne

Study: pubmed.ncbi.nlm.nih.gov/36931...
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[@locomike102]

I was Keto for almost 18 months and it made every facet of my lipid panel worse. I lost a ton of weight but my blood markers went from pretty good to pretty bad. I made a plan with my doctor and I went off of keto and we rechecked my blood after 4 months. Everything got better. My doctor (who I think is very good) told me that he sees many patients with positive lipid results with Keto and some, like me, who respond poorly. It all depends on the individual. Edited to add: I continued to lose weight on a traditional balanced diet, and I felt much better--more energy, better mood, etc...

[@elisabanks7185]

Similar effect. Lower weight but poor lipid profile. Now back to high fiber veggies, healthy fats, and lean meat.

[@wellnesspathforme6236]

If you track your TG/HDL ratio, how did mover from pre-keto through keto through post-keto? So-called normal lipid profiles kill about as many people with heart attacks as so called bad lipid panels - be careful what you consider friendly. This is a great presentation by Dr. Lustig: kzbin.info/www/bejne/eWTVpIF5e7N0rZo

[@milp5761]

What kind of keto? Guzzling lard, butter, and bacon fat would probably caused worse lipids than eating nuts and avacado fats.

[@bryceb1234]

Please keep in mind that the underlying premise of LDL bad and HDL good is wrong. The type of LDL is critical, and yes, higher levels of the wrong type of LDL is VERY bad. But high levels of good LDL creates a VERY protective effect. The problem is that the diet of most people oxidizes LDL, which causes future issues.

[@wellnesspathforme6236]

@@milp5761 Again, the assumption that a lipid panel accurately measures a good state when half the people who have heart attacks have a "good" looking lipid panel needs to be exhaustively questioned. How is this not obvious? Dr. Lustig provides a great place to start here... kzbin.info/www/bejne/eWTVpIF5e7N0rZo What were the TG/HDL changes? Maybe they improved as the standard model lipid panel looked worse. If so, I go with TG/HDL. Also, look at your remnant cholesterol. kzbin.info/www/bejne/b2mXYaGjrpibiLc and... kzbin.info/www/bejne/pGHMiWVohc9ke8U ... The medical system is rigged in that it adjusts its goals as populations change -- so the sicker society gets, they adjust the lab values in accord with the sick population. So chronic illness is normalized in the testing procedures. Anyone who has taken statistical process control knows that this is absolutely not what you want to do UNLESS you want to hide the changes that are occurring.

[@eatmeatandliftweights5754]

Keto has helped me to control sugar cravings, constant smacking and binge eating, I have been eating this way for years now. My cholesterol is high, triglycerides very low, A1c low and coronary artery calcium score is zero. I don’t have any medical conditions or nutrient deficiencies and no need for supplements!

[@seal869]

Cool story

[@unknown-vo3di]

Very common story with keto dieters. It's known that ldl is a non factor for heart disease even the American heart association doesn't care about it.

[@Behindthejab]

Anecdotal evidence much?

[@lenguyenngoc479]

uhm yikes, like half of the heart attacks in patients with low CAC score for young people under 50 its predicting power is worse than flipping a coin for older people, yeah now its predicting power is better How old are u

[@carlosjosejimenezbermudez9255]

@@Behindthejab perhaps it is anecdotal but being able to control sugar cravings and binge eating is a bigger plus than you'd imagine. Keto (or whatever my higher protein version of it is) is what actually allowed me to lose some weight and remain with that weight gone instead of going back to it. It also keeps me with proper satiety levels and little cravings. I'm not a zealot, and I don't plan to be one. I'll have diet breaks every now and then, with limitation, nothing super high sugar, but a diet break, nonetheless. But I don't feel anywhere near as bad as 4 years ago and I'm only 29. My energy levels were horribly low all the time, I was hungry all the time and would energy crash constantly. Based on what I now know of diabetes I think I was on my way to either being diabetic or a pre-diabetic at the very least.

[@cheffatgrams]

I’ve lost 85 pounds on keto and kept it off for almost 4 years now. I’m with you because I could’ve stayed unhealthy or became more healthy on keto. Every diet and every lifestyle will have those that like it and those who don’t. We need to do what works for us because DOING NOTHINGS definitely works for NO one.

[@BigRon092]

Adkins pushed a keto diet. Read his book all the way thru. He said that after you've lost the excess weight go to a low fat maintenance diet.

[@bryceb1234]

Those looking for optimal health are more recently starting to tout a low carb diet intermixed with carbohydrates to create a fat adapted, but glucose-using mitochondrial mix. I find this works pretty well. No crashes from carbs, but consistent energy throughout the day. Those with strict keto will tend to have extreme carb reactions after a time. I noticed this myself.

[@notacrew69]

For Al-Gore!

[@joerockhead7246]

Tipper too

[@jeffhughes4058]

Dude had rhythm

[@dcj84]

He has that rhythm!

[@natecastronovo]

My blood levels have gone from slightly high LDL to perfect and I've maintained that consistently for about 5-7 years of keto now. It's very important to understand that keto is a broad diet - if you're eating lots of high saturated fats, you will raise your LDL, but keto doesn't require you to eat more saturated fat. You can focus on fats from olive oils and fish while also increasing fiber intake and still limiting carbs to a minimum. "clean keto" is even a broad term. Maybe we should really specify that if you want to aim for health, "clean, Mediterranean keto" is currently the best option.

[@stellasternchen]

I wish there were studies about that. I believe this is the case. I mean it would be nice to tell people with lipedema that they can eat keto long term while making sure lipids are not significantly worsening.

[@kimdavis7812]

Great video Layne 👍

[@rj4545]

My experience with keto Tried for 2.5 months lost around 9kg but it screwed up my lipid profile ( before keto it was as normal as overweight person should have) Just after keto Cholesterol shoot up to 280 mg/dl Triglycerides to 410mg/dl Vldl to ~60 mg/dl Ldl direct to 260 mg/dl Lowered hdl to 30.6 mg/dl My doctor strictly suggested me to start high fiber high protein diet immediately and come off of keto It took more than 9 months to level of my lipid profile according to my weight ( have slight more ldl high and hdl low, I still have 20 kg to loose, total weight loss 17kg) I don't get the hype around keto, it screwed me up, glad I'm back to normal

[@samuraibat1916]

The hype typically involves ignoring LDL or downplaying its significance.

[@jimsturt]

@@samuraibat1916 until you're on the gurnee in the cath lab 😂😂

[@christianjames92]

Ok and what were you eating on the diet?

[@bigal6114]

I did an N=1 experiment using the keto diet to lower my A1C. I was 59 (2012), very active with a BMI of 20 when an A1C result came back as 6.1. This was following a fasting glucose test of 104. My doctor advised me to cut my carbs. That worked for a few years, but eventually my A1C started to climb. Each time it did I would reduce my carbs by 100g. When I was down to 200g per day it still went up. I listened to a podcast about the keto diet. I then read a book about. Since starting keto my A1C hovers around 5.7. My LDL cholesterol did go up. I started taking a statin to lower it.

[@Locke19901]

I just watched your last sit down with Peter, it was great as usual.

[@Joseph1NJ]

Mr Norton takes a statin, and Peter takes a PCSK9 inhibitor. That tells me they both take their CVD risk seriously.

[@leigh5863]

Well said Layne, very balanced view👍

[@danaso2567]

Thank you for the educative information

[@christianjames92]

I was grossly overweight. Touching 400 pounds. I lost 120 pounds in 8 months on keto and went from pre diabetic to having my fasting insulin back at 70. Do I think it's the healthiest diet long term? Probably not. But if you're in that pre-diabetic range and you need to lose a fuck ton of weight there's no other diet I would recommend more. Keto+ fasting+ even resistance training just melted the fat off of me. What Layne is saying is correct though. My first month on Keto I did the stupid shit like drinking bullet proof coffee, eating eggs soaked in bacon fat, eating ribeye steaks soaked in butter, etc and I didn't lose weight and my cholesterol went through the roof. If you're going to do keto you have to fucking do it smart. Get into a calorie deficit, watch the saturated fat you're ingesting, watch how much actual red meat you're ingesting, etc. This should be common sense.

[@tara55886]

Thanks Layne!

[@jimjim-hx6fd]

I think you nailed it: most people's idea of keto is bacon, butter, cheese, and bunless burgers. Unless you're genetically gifted, that's obviously going to have a negative effect over time especially after weight loss stalls. You can also do a low fat diet that involves a lot of high GI junk carbs. I's all about the right carbs or, in this case, the right fat. Problem is, I think bacon and burgers are a lot more tantalizing, and easier to come by, than salmon and greens for most people lol

[@donewittit6607]

When did greens become hard to come by

[@scotchbarrel4429]

Before I start watching this vid, yuss! Thank you for doing this topic! Also looking forward to Dr Palmers supported research on the keto question in relation to mental wellbeing, hope you cover that study too when it eventually comes out. P.s. change your KZbin handle, you'll improve the algorithm, it works for Huberman and Galpin and Friedman 👊😎

[@pauloconnor1879]

This was your Nicest Video about keto diet! 😊

[@outatime88mph]

Hey Layne, have you given your opinion on ashwagandha? Worth trying out?

[@aaronjwallace501]

Layne growing!

[@rishiramkissoon6976]

Thx for the lipid update!

[@chibbyylol]

As said again: do a diet you can stick to

[@SolidNate99]

keto would be easy to stick to. The only real problem/inconvenience would be when you're traveling. Carbs are nice to have when traveling (Granola bars etc. for snacks) But you could do things like various nuts for snacks.

[@Metarig]

it's the easiest to stick to American standard diet 🤷‍♂

[@Seanonyoutube]

@@Metarig exactly, lol. Do a diet that supports your health AND which you can stick to.

[@tanyasydney2235]

@@Metarig Haha.

[@SaamanthaTM]

Can you do a video about nutrition when you don’t have a gallbladder or have thyroid meds ? I keep seeing this a lot lately & just want to learn more :) currently taking a course as well

[@yeeyee325]

Great video

[@user-pe2ee7en5t]

do a video on ashwaganda and all the test boosters and if i should take it as a natural lifter pls

[@yosernagme3204]

I love how fast I am when new video coming 😂❤️

[@shoulung6203]

One reason I've heard for increased LDL with a calorie restricted keto diet is that your body breaks down your fat cells which releases LDL into the bloodstream. That makes sense to me, but not sure why you wouldn't be breaking down fat cells with any calorie restricted diet.

[@tanyasydney2235]

Yea, I just heard Dr. Ali Nadir's video about that. Not sure if I believe this "excuse" for high LDL. And you make a good point.

[@ItsEskai]

I really appreciate Laynes ability to look at the bigger picture and not fearmonger. I personally am low carb/keto and find this way of eating helps with my hunger signaling. Personally my LDL is 85 while consuming a lot of saturated fat but I will try and monitor these markers to see if things are trending in the wrong direction. On a side note, thoughts on triglyceride to HDL ratio and its predictive value for risk vs LDL ? I do admit I'm a little biased because my triglycerides are 56 and HDL is 70 and would love for that to be a powerful indicator.

[@colefiegel5847]

All the recent papers have shown pretty much the only thing that matters is ApoB for heart disease risk. LDL makes up the majority of ApoB so that should be your marker if you don’t want to get your ApoB taken

[@SM_RD]

LDL level is impressive, I'm curious what your saturated fat intake looks like? Do you happen to know how many grams you are typically eating per day?

[@renatodoe6661]

​@@colefiegel5847 Wrong. Your blood sugar matters very much. High blood sugars means poor heart health.

[@colefiegel5847]

www.ncbi.nlm.nih.gov/pmc/articles/PMC9791017/#:~:text=They%20found%20that%20high%20Apo,high%20non%2DHDL%2DC.

[@applerunner1184]

Given that HDL is not a factor for predicting heart disease risk, any ratio’s that use it are considered useless. The current thinking is that that the only thing that HDL is useful for (for predicting heart disease risk) is for calculating Non-HDL-C which is a (less reliable) alternative to ApoB (you can calculate from your lipid panel)…

[@palmenable]

Great video Layne! Have you seen any good studies looking at Keto and heart disease or mortality? Would be interesting to se if this raised LDL actually cause harm or not. As some people claim it does not increase risk for heart disease, given all other blood panels look good.

[@MiguePizar]

I don't know about keto, but at least with intermittent fasting eating any kind of food, my LDL is even lower than the norm, my HDL is higher than the norm, don't know if that's good or bad, but all my blood markers are like above (the good ones) the norm, and the bad (below the norm). Thanks for the video as always.

[@noneyabusiness1054]

Statins have little to no effect on your mortality rate. So the claim that medications that lower your LDL reduce your risk of cardiovascular events is untrue. This is seem most in the newest LDL lowering drugs PCSK9. The studies had a higher mortality rate in the drug group vs the control (placebo) group.

[@JeffroJames]

Excuse me? Every single meta analysis has shown a 30% reduction of coronary events with statin therapy. That's their job and they do it quite well.

[@Metarig]

fair enough.

[@jamesatkinson5805]

Great video, i think part of the problem now is the Zero Carb aka Carnivore diet is popular, automatically you have people just eating saturated fat, and some people doing great, but others having problems with blood markers, but they have made this diet an identity, so they are told to " give it time" In the past quite a few low carb diet proponents recommend a diet higher in vegetables but also leaner somewhat protein sources and also fat sources from avocados, olives, and nuts and olive oil and other monosaturated fats so more of a Mediterranean Low Carb diet, which seems to correct the problems Layne is mentioning.

[@Ryan_DeWitt]

Haven't heard about the keto diet much lately. Apparently it wasn't extreme enough and now the carnivore diet is all the talk.

[@adidkjf]

carnivore is keto, so its basically the same...

[@Ryan_DeWitt]

@@adidkjf No where near the same. Keto people generally eat veggies, nuts, oils, seeds, cheese etc. The true carnivore diet is petty much meat, often mostly red meat and eggs.

[@adidkjf]

@@Ryan_DeWitt but the same mechanics for your body, your are in ketosis.. fat Adapted, not using carbs as fuel.. thats what i meant..

[@JATHARMOHAN]

Informative

[@elmeric7086]

Nice video. Have looked at the ApoB level which seems to be a better marker for ACHD ?

[@jimsturt]

apob is about 90% correlated with ldl. if you know your ldl you have a good approx of apob.

[@delanaveirs3411]

I was a vegetarian for most of my adult life & had low LDL but adding meat into my diet my LDL is higher. I eat a lot of vegetables. I also have never been obese & my LDL had been high even when I weigh 125 lbs

[@IamJonsCranium]

Do these studies differentiate between ldl from fat and vldl from the liver? What percentage of people with high ldl are so from excess fructose/processed carb/trans fat intake vs animal saturated fat?

[@stephanjaure3344]

Could you debate dr aseem malhottra (british cardiologist published in bmj findings in contradiction with what you say). It would be interesting to hear both your perspectives

[@Danielm103]

My lipid panels were normal on keto, my diet was mostly salmon, avocados nuts... I know some people were slamming double crème, butter chugging, bacon… so yeah, there’s lots of nuance lot my weight, now i just watch my total calories.. still love the salmon and avocados tho lol

[@Junitaco]

Problem with the ketogenic diet is that a lot of people who are doing keto are, in fact, not doing keto. Either because they underestimate their carb intake or, more commonly, eat way more calories from protein than they should.

[@Physionic]

From my own study analyses, your intuition is correct about dropping weight and seeing a reduction in LDL. Additionally, consuming more unsaturated fats instead of saturated fat on keto also reduces the LDL effect.

[@karlhungus5554]

This is healthy, right? kzbin.info/www/bejne/rH6Qc5pte6mZsNk While I realize that Keto and Carnivore diets can be structured in a variety of ways (I don't follow either), some of them are just beyond silly to me. I also have to wonder why some of them continue to remain so overweight. Well, actually, that's not true. I know why. I wonder why _they_ haven't figured it out. Rather than changing, they do even more of what isn't working.

[@robert111k]

My case is totally the opposite. My LDL-c goes to the same roof no matter weather I take saturated or unsaturated fat and after losing 25 pounds and reaching my ideal weight, my LDL-c was almost three fold higher than when I started Keto (from 92 mg/dl to 256).

[@Physionic]

@@robert111k sounds like there’s something to discover there. An interesting experience - thanks for sharing.

[@robert111k]

@@Physionic, not really. As a matter of fact it seems to be quite frequent. They call us lean mass hyper responders, I think, and we are about 30% of the population.

[@seal869]

Your own analyses?

[@conisalgado1294]

Can you please make a video covering if we can get enough protein eating at calorie maintenance and eating just fruits and veg? Many fruitarians are saying we can because all foods contain amino acids and animal protein is broken down to amino acids so supposedly better to get it through fruit. I know it’s extreme just wondering if it’s physiologically possible.

[@AngelofD69]

Can you please attach studies that show a linear correlation of LDL exposure and risk of cardiovascular event

[@nowayjose596]

It'll be nice when we all just move to apoB testing and leave this LDL vs HDL vs triglycerides confusion behind. Much easier (and likely more accurate) to know that something that raises apoB increases cardiovascular risk, and something that lowers it decreases it.

[@Seanonyoutube]

Non HDL-c is also a pretty good marker and is included with any standard lipid panel.

[@es7818]

I was on a keto diet for about eight months, lost about 5kg (all I was trying to lose) - slept like a baby, great energy during the day and my lipids got better! This was with a lot of macadamias and avocados, less of the bacon and cheese. There's really no need to guess and worry about it, just get your lipids and diabetes screening tests checked, everyone's different.

[@CR250RidR]

what about ketos effects on your mood and cognitive function and energy levels (for people who are type 2 or pre diabetic)

[@TheTechNiShan]

Do a video on bryan johnsons longevity experiment

[@staciwolfe7902]

I remember reading something about the size of the LDL molecule being different on a ketogenic diet, and somehow that mattered. I wish I could remember exactly. Any info on that?

[@user-zl8fd8ko7d]

Yes, he left out that on a carnivore or keto diet with high saturated fat, the particle size of LDL increases as well as the number of the LDL increases. Some believe that seed oils increase oxidation of LDL which is another factor

[@Joseph1NJ]

Interesting. I believe all LDL particles are arthrogenic, some more than others. So until insurance starts to pay to test ApoB, which might be a superior biomarker of risk, if we keep LDL low, we effectively lower CVD risk regardless of size.

[@AngelofD69]

@@Joseph1NJ ApoB is a cheap test just pay for it

[@kimmoffat6429]

That Gore laddie sure got rhythm!

[@GoneCarnivore]

I'm doing Carnivore, I tend more toward Dr. Berry's attitude toward carnivore. These Keto diets lower blood pressure as well. Some of the Keto pushing Doctors are now saying cholesterol levels don't matter. I honestly don't know but I'm open minded to any research.

[@MrCalyho]

your guess turned out to be wrong though. apparently low body weight was a higher perdicter for high ldl.

[@sxhrgvs]

Very interesting. Never tried it. Not sure I ever will but interesting nevertheless.

[@C0d0ps]

To whoever reads this, I hope you have a wonderful day and no matter what stay happy as that is what matters most in life, You are truly amazing and no one can ever take that away from you, Be happy and enjoy life, We don't have long on earth so make the most of it, We’re all gonna make it brah 👑

[@jockekaske]

algor alright!

[@sarahbresson4826]

Layne, as I understand it. Some of our LDL submolecules are protective and we need them. Do any studies actually look at this? Also isn’t it true that many people who have heart attacks don’t even have high ldl?

[@stellasternchen]

I can explain that to you. No there are no submolecules of LDL that are protective. The problem with LDL is its habit of getting stuck in our artery walls, causing chronic inflammation in there leading to plaque formation. The actual arteriosclerosis, the calcification of the plaques is the bodies way of sealing off this inflammation preventing further harm in form of ruptured plaque traveling to the heart, lungs or brain. What makes LDL getting stuck in the artery wall is a protein called ApoB they carry, that has a affinity of binding to the proteoglycans of the artery wall. All subtractions carry this protein. Subtractions differ in size and content. Larger subtractions carry high ammounts of cholesterol, smaller subtractions carry little. The way we mainly measure LDL particles is via the cholesterol. This measurement is very accurate if you have mostly large particles, which is a sign of good metabolic health. High LDL cholesterol equals high particle number. If though there are lots of small LDL particles with little cholesterol LDL-C becomes very inaccurate in estimating LDL number. In this case normal LDL-C can mean a high number of LDL particles. Small particles are often seen in people with insulin resistance, prediabetes and diabetes. They carry mostly triglycerides, so elevated triglycerides might be a sign to look out for them. There is a better way to measure LDL particle number. You can measure the ApoB protein I mentioned above. It is one of the best measurements of cardiovascular risk. Some cardiologists advocating for it to become standard instead of LDL-C. An other reason to get cardiovascular disease is a different lipoprotein, that increases the damage LDL can cause, when attached to it called lipoprotein a. It is a genetic factor, most people have this lipoprotein in negligible small amounts, but some have high amounts. These people need to keep their LDL very low, as the Lp(a) makes it more harmful. A good paper explaining LDL size and subtractions is „Low-density-lipoprotein and size and cardiovascular disease: a reappraisal. Head over do the Physionic Chanel, where Nic - a nutrition researcher is explaining this paper very well. You can also head over tho the Nutrition made simple! channel, there is an interview with the researcher starting the research on LDL subtractions and cardiovascular disease, explaining what was found. I think that is more credible then heading to low carb channels misinterpreting that research.

[@lientforjuve8118]

I heard once that a studies that compare consumption of saturated fat (coconut oil 90++% sat fat vs butter 60++% sat fat) cunclude that people that consume coconut oil didn't raise their LDL, infact have lower LDL compared to butter. I also heard that statin didn't improve hazard ratio compared to control. I believe we must put LDL in the context. I dont think high LDL in insulin sensitive guy have a high risk in cardiovascular disease. I think there is no study about risk of cardiovascular disease that compare high LDL with good HDL/triglycerides/ketogenic diet, with the control.

[@martinarnold5239]

could you speak to the claim that keto diets increase insulin resistance. Also does keto/low carb really help blood sugar control. That is to say, if you don't eat high carb foods anyway you aren't going to know if you have good blood sugar control. A bit like not knowing if you're broken leg has healed because you aren't trying to walk on it. Thanks

[@tanyasydney2235]

Well I can tell you that both keto and Carnivore increase my insulin resistance. It's very noticeable. And you're right, they "help" blood sugar control only while and because you're avoiding sugar. Good analogy with the broken leg.

[@SolidNate99]

Do you have any videos on glucose levels on carnivore and keto diets? I have seen that they have high glucose and A1C.

[@weisscoaching]

The reason might be that when the body is forced into producing glucose through gluconeogenesis such as during very low carb diets , in combination with exercise it can cause higher blood glucose levels . The body is also "resistant" to insulin so if such a person eats carbs and blood sugar spikers, it is elevated for longer time. That's my suspicion

[@wheelofcheese100]

The a1c thing they say that RBCs live longer so you end up getting high a1c but high BG is usually high in some of the carnivores. Someone just did their fasting BG and it was 99. How did that not set off red flags?

[@SolidNate99]

@@wheelofcheese100 yeah the longer lasting red blood cells is just a theory. I think they're just clinging on to things trying to justify the damage they are doing.

[@libsonteresa5695]

Keto enthusiasts say it is okay to have high blood sugar and insulin resistance on keto . They explain the science . I don’t see how body says “ ah ! He is on keto . So let’s treat the blood sugar differently and ignore it “.

[@komoru]

High blood glucose can be tamed through longer periods of fasting. If you get a CGM (continuous glucose monitor), you can monitor your levels and what you're eating to see what is causing it to spike.

[@ClickToPreview]

Yeah, but is that LDL oxidized? Any studies teasing out this potentially confounding variable Layne? Does the research consistently show all forms of LDL-c to be atherogenic? Or just OXIDIZED LDL-c?

[@Seanonyoutube]

Oxidation is a step in the atherosclerosis process. It’s not a type of LDL in and of itself. All Apo-B containing particles can get lodged in arterial wall, and once it’s lodged, oxidation over time is inevitable. That’s why ApoB (or non HDL-c) is the bottom line most important metric to pay attention to along with blood pressure, followed by A1C and TGs.

[@danteburritar2822]

Wish everyone knew that LDL itself is not a problem. Plenty of people live to an old age with no heart issues with very high levels of LDL. Also 25% of those who have a heart attack have low LDL. The root cause of athersclerosis is inflammation caused by long-term high blood sugar, smoking and stress. ONLY if the arteries are damaged by those factors can some types of LDL be a problem - i.e. small LDL particles such as LP(a) or oxidised-LDL. If keto increases good big fluffy LDL particles that is healthy. This study should have measured LDL particle size (LDL-p).

[@Medhead101]

Have you seen the correlation between LDL levels and all cause mortality though?

[@Seanonyoutube]

We don’t much care about correlation studies once human RCTs and Mendelian randomization studies exist.

[@unholyquail4560]

@@Seanonyoutube Yup the Mendalian studies really put an end to the discussion at this point. Nothing to argue about anymore.

[@xprcloud]

LDL is not causal in cardiovascular disease, and it’s the overall macros that effect LDL, consuming high cholesterol foods does not impact LDL, it’s the macro balance

[@Hupernike45]

OK. How about the fact that large buoyant LDL particles do not contribute to CVD, but small dense LDL particles do?

[@krisfarrugia6490]

Hey Layne, could you please attach any references with your claims? Thanks!

[@zene2550]

www.ncbi.nlm.nih.gov/pmc/articles/PMC5040825/ if it was that important we would have seen it in this study or traditional pacific islanders, especially the Tokelau who consumer 80 cals from sat fat. Mendelian randomization is very confounded

[@komoru]

He can't because SUGAR and smoking are more strongly correlated with heart disease than LDL See a video on youtube titled "The Great Heart Disease Fat and Cholesterol Deception: Not Correlation ALWAYS Means Not Causation." and he gives you many citations, and he's not trying to sell you any programs or supplements like Layne is.

[@zene2550]

I thought this comment disappeared. It's funny how he goes hard on Sat fat and is soft on sugar. Literally say don't replace Sat fat with refined carbs

[@krisfarrugia6490]

@@komoru I skimmed through the video, I don't have much time at the moment to rebuttal this - I am not familiar enough with Ancel Keys' work, so I prefer not to comment about that. Plant Chompers has a whole video on that, if you're interested in listening to both sides: "Saturated Fat: Debunking Nina Teicholz and Denise Minger". Anyhow, if you're really interested in considering the totality of evidence, and not just a few studies, taking into account population studies, RCTs, meta-analyses and systematic reviews, check out Nutrition Made Simple's videos on Saturated Fat, Cholesterol and Cardiovascular Health. We can even put Keys' work in the trash - the totality of evidence consistently points into one direction: the reduction of saturated fat (8-10% of our total calories) reduces cardiovascular events.

[@komoru]

I see the evidence pointing in the exact OPPOSITE direction. Meta-analysis: JAMA Intern Med. 2016;176(11):1680-1685. doi:10.1001/jamainternmed.2016.5394

[@hata6290]

The ketogenic diet is a suboptimal diet for the majority of people, or just overall

[@retromec4757]

I did like the video but I don't know if I can it again

[@fla8731]

algo

[@ven412]

I’m not a huge keto or non keto fan, but one question. You say ketogenic diets are shown to raise LDL which is linked to a greater risk of heart disease (forgive me if my paraphrasing is incorrect). Are you saying directly ketogenic diets raise the risk of heart disease (controlling for any other independent factor of course).

[@SM_RD]

I think he's saying that most folks tend to over consume saturated fat on keto diets. The high level of saturated fat is likely the culprit causing increased LDL. If you were to implement keto eating mostly lower saturated fat foods, you may not see the negative lipid impact. Especially if you lose weight from the diet as well.

[@komoru]

Layne is making an assumption that a correlation of LDL is strongly linked (causitive) to heart disease, which it is NOT. HBA1C is a better test/predictor, as is a CAC (coronary calcium score). LDL is NOT. You can have high LDL and manage glucose just fine and have a perfect CAC (meaning a near ZERO risk for any coronary event). There's a great video on youtube which shows this (with citations): "The Great Heart Disease Fat and Cholesterol Deception: Not Correlation ALWAYS Means Not Causation" If you dig deeper into the "meta-analysis" that Layne cites, you will find that these studies are funded by pharmaceutical companies trying to promote statins and cholesterol lowering meds. My father died of atherosclerosis. I've done lots of research on it because of this. He was pre-diabetic. He had a "great" lipid profile according to his doctors. He was not really fat either. But he ate LOTS of sugar. He was absolutely a sugar addict. Sugar (and cigarette smoking) are more highly correlated with CVD and atherosclerosis than LDL. You can be very healthy and have high LDL as long as you keep your waist circumferance in check and your body manages blood glucose properly.

[@Seanonyoutube]

@@SM_RD a lack of soluble fiber on low carb diets also tend to elevate ApoB. Consuming psyllium husk, oat bran, etc could help fill in that lack.

[@igpa70]

So , the question becomes: What protocol would help the most with building muscle, burning fat and not increasing risks of metabolic disease?

[@mcfarvo]

Yeah, not gonna be doing the eat tons of fat diet; if I ever enter keto on a cut due to dropping carbs so low, no biggie, but I won't be adding in fats to have a high fat ratio diet

[@Eliaael]

Where the people on the diet fat-adapted? It usually takes a few months to see reductions in ldl.

[@PSA78]

It seem to take about a week for the body change over, demonstrated by research done by Kevin Hall in 2 month trial (among others).

[@staciwolfe7902]

​@@PSA78"change over" yes. It takes a very short time to be in ketosis. But it takes much longer to actually become adapted, and do it efficiently.

[@PSA78]

@@staciwolfe7902 What mechanistic function are you referring to? Citations would help.

[@canadiensuperman6496]

most people i know on the ketogenic diet do dirty keto bacon, red meat full fat etc so yeah. Your cutting out a whole food group you are bound to miss out on nutrient the best plan is Mediterranean diet tones of studies keep a healthy weight be active meaning walk i am 50 i changed my training can't lift heavy anymore due to back pain had tone of prolotherapy and PRP but you still need to be careful not to re injure. Simple changes go a long way

[@JasonBuckman]

Red meat isn't dirty. Red meat is part of healthy clean keto. Processed meats are dirty, red meat isn't part of that.

[@canadiensuperman6496]

@@JasonBuckman i am back on keto been about 1 month now, food allergies are gone and i feel a lot better

[@jggg31]

What a boss

[@howy3333]

Your analysis as always very fair and impartial. As usual Bottom line losing weight outweighs the negatives

[@kai6424]

You know all the cheese would actually be ok for you if you didn’t live in USA . Raw cheese unpasteurized has a lot or beneficial bacteria and enzymes that make it a much healthier option

[@4u2nv503]

Buen video

[@denisehawkins6812]

What about carnivore?

[@bodi.a.r]

Going to watch this, first thing tomorrow morning-FOR THE ALGORITHM

[@GayBearBro2]

For the algorithm!

[@lukeeverett6768]

👍

[@fantasticallyfit6030]

A1C is more or a predictor for heart disease than LDL. So if someone is diabetic or has metabolic syndrome then the keto diet….. seems to be the better way to go.

[@aaronbailey9454]

For the 💪🏽

[@genta88able]

For the algorithm 💪

[@AncientYouth64]

What about triglycerides?

[@Seanonyoutube]

Indicator of metabolic health. And tends to come down together with LDL/ApoB. (But lowering TGs without lowering LDL only marginally lowers risk).

[@klocugh12]

Turns out isocaloric diets with different macros do turn out quite similar health results, huh?

[@donwinston]

Almost everyone who eats a ketogenic diet is eating a "bacon cheeseburger without the bun" kind of diet. In addition they doing stupid things like putting butter or coconut oil in their coffee.

[@Seanonyoutube]

I had high ApoB on a keto diet consisting mainly of fish, unprocessed lean meats, olive oil, dairy, and lots of vegetables. It came down once I cut out the chicken and beef and introduced wholegrains and legumes back.

[@komoru]

Layne "assumes" LDL is bad. If that can be disproven (which it has), then his entire argument falls apart.

[@unholyquail4560]

Yes.. but it cannot be stated disproven at all. Rather it has been proven that in order to disprove the concept you would need to comply to a whole paragdime change where you need to be explain no only this but more and proof it. However the body of evidence in meta reviews, RCT's, mendelian randomisation and cross spicy mechanical research shows LDL is a proper indictor for correlation of heart disease. Where ApoB is the causal link consisting large from Low density lipoproteins. So I don't know what pigeon holed or singular study you read. But given the entirety of literature and explained machanims... they has not been a singel compilation of studies proven a different outcome where considering genetic variance. That is why the Mendelian randomisation was the nail in the coffin to any deniers on this subject.

[@TheProchargedmopar]

What you think about Dr. Alo? Dude is crushing my Carnivore Dreams. 😂

[@tanyasydney2235]

Thanks for bringing him up. I'm going to check out his channel.

[@DrTomMD]

Right on. Very rare - if not a ghost - to see anyone do Keto with high fiber and low saturated fat. It’s appeal is a certain subsection of high risk foods are “unlimited” in trade for refined carbs but also most high fiber foods linked to longevity (eg legumes). Medically monitored partial meal replacement monitors diet that’s high in fiber, low saturated fat does just as well for A1C (see WHY WEIGHT program at Harvard/Joslin - run by colleague Dr Osama Hamdy) True story. Henry Ford Health patient of mine, an educator at Wayne State University, MBA and licensed attorney with a lifetime of yo-yo dieting, engaged my coaching and program guidance (at that time at Henry Ford West Bloomfield Mich Hospital), leveraging meal replacements along with concomitant long-term lifestyle preparatory intensive lifestyle education with meta-flexitarian, personalized eating. Ricardo had severe insulin resistance with borderline type 2 diabetes (A1C 6.4%), hypertension on 4 meds and major dyslipidemia at the start. Now, seven years later maintaining a 100 pound weight loss and better fasting insulin levels than me (kind of pisses me off but in a good way). Keto twist: His physician brother at one point approximately three years ago wanted Ricardo‘s support to start keto by doing it with him. Wisely, Ricardo consulted me. I said go ahead but let’s make it a controlled and monitored situation particularly for lipids, blood pressure and insulin sensitivity. I told him I predicted three things all of which came true. His fasting insulin and overall insulin sensitivity would remain good while switching from meta-flexitarian to Keto but his blood pressure (due to the typical stealth salt that comes with keto) add LDL particle number (far more precise measure of LDL risk than standard LDL cholesterol, or even non-HDL) would shoot up significantly. And…drum roll please…That’s exactly what happened. After only a little more than one month on keto (we tested him one month after initiating it) upon receiving his NMR Lipoprofile results (and also noticing his blood pressure was creeping back up via self-monitoring), he immediately told his brother that his bro was on his own. Ricardo went back to his Flex5 (meta Flexitarian) lifestyle and all continues to be well.

[@jimd4322]

I would never do keto. Load up on fruits and veggies, oatmeal is a great breakfast, have a good balance of carbs, fats and protein, don't smoke, exercise a lot and you'll be fine. There aren't any secrets.

[@Itsmekvn]

For the algorithm

[@hapekatten9935]

Aaaalgorithm

[@joey-bladez]

Hmm. Intriguing, Dr. Anthony Chaffee shows some fascinating science that opposes this info. You two should have a friendly debate. He is, however, very knowledgeable so you have been forewarned. 💪

[@luislaurens1535]

Algo

[@andrewzach1921]

Comment for the algorithm

[@bunny2chandu]

Gorithm et Al

[@andrasbajusz9290]

Algor

[@zaybx]

Fta!

[@karlhungus5554]

Comment for the KZbin algorithm gods.

[@Greg_Chock]

Do you have a link to the study showing relation of CVD and lifelong exposure to LDL-C levels? Just want it for future reference.

[@komoru]

Check out Pottingers Human youtube channel -- his latest video titled "The Great Heart Disease Fat and Cholesterol Deception: Not Correlation ALWAYS Means Not Causation" has several citations on a how LDL does not correlate with CVD.