Brad Stanfield & Fisetin: SURPRISING Detail! | Study Analyzed Ep.2

Last year, Dr. Brad Stanfield posted a video on why he stopped taking Fisetin and Quercetin,
two of the most popular supplements in our longevity community.
This comes in contrast to many other longevity experts such as Dr. David Sinclair, Dr Robbins, and Dr. Kirkland.
This contradiction was based on a new Fisetin study conducted by the prestigious ITP organization showing no lifespan benefits nor senescent cell removal.
And today, we’ll do a very thorough investigation into the Study brad Stanfield mentioned.
This study was conducted by an organization called the ITP.
What is the ITP?
What are their weaknesses that NOBODY speaks about?
And what did they find in their fisetin study? We’ll do data interpretation of the information that we do have.
I have found something that shocked me about their study which I’ll show you today.
And what do I do with this information - do I take fisetin or shun it like Brad Stanfield?
✅ I've published a free concise report on QUERCETIN after 6 months of research with 300+ studies, at:
www.WellnessMessiah.com/Gift
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✅ Suggest watching next:
• EXERCISE, Resveratrol ...
Study References:
www.nia.nih.gov/research/dab/...
journals.plos.org/plosbiology...
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✅ The favorite videos on this channel - playlist:
• Longevity Favorites
Chapters:
00:00 Intro
3:44 The Perpetrators: ITP
12:28 The Supporting Actors: Mice
23:30 The Secret Agent: Fisetin
25:33 Questions for the Study
31:22 Entering the Crime Scene
44:01 What Do I Do
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The Wellness Messiah podcast is available on Spotify, Apple Podcasts, and Overcast.
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Credits: Scott Buckley
Disclaimer & Disclosure: The information in this video and/or at this channel is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge, educational and information from the research and experience of Rimon, who encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional.
Rimon is not a medical doctor. If there is a contradiction between the advice here to your doctor or local authorities, always go with the doctor and the authorities.
Statements made, or solutions suggested in this video and/or at this channel are not intended to diagnose, treat, cure, or prevent any disease.

[@WellnessMessiah]

I've published a free concise report on QUERCETIN after 6 months of research with 300+ studies, at: www.WellnessMessiah.com/Gift Get a short version of this video at: kzbin.info/www/bejne/epe9lGewl9eDmtU

[@scottymackay1801]

Hi Rimon. Just a suggestion to try and cut down video lengths. I think you will get more views. You could also take 3-4min segments from your longer form and post those. I would also post some shorts with salient points. This will boost your viewership as it's difficult to spend 50mins on this one topic.

[@deansusec8745]

Yup. I personally dont watch anything over 20 min

[@WellnessMessiah]

Thanks Scotty. The truth is I currently do these with 30% time as 70% goes to my wife's recovery from stroke. I'm one man show now. I have to choose one medium. I'm not on shorts, twitter, insta, or Facebook. The cool thing about VOD is you can divide the video watch on your own - if you think the content is high quality enough that could impact your health.

[@russelladams9147]

Not to sound pretentious, but please don't listen to folks who need an abbreviated approach to viable data. You can't always cater to the non-grad-school folks. So often we see a lack of academic rigor among viewers - a clear attestation to a lacking post-bac experience in today's TikTok age. Certain folks need to accept that depth is often necessary for a complete picture. If they can't handle it, then it's arguably a Darwinian response, and those viewers have to accept the consequences of limiting their understanding. /rant off

[@scottymackay1801]

@@WellnessMessiah All the best to you and your wife!

[@WellnessMessiah]

@@russelladams9147 Thank you for the encouragement. The truth is if someone needs 4 min videos, they have plenty of other people for that. Brad is one example.

[@saent21]

I very much appreciate your unflinching and unapologetic analysis of so-called "gold standard" studies. We need more people like you who are competent, willing, and able to challenge scientific assumptions. Thank you!

[@WellnessMessiah]

Thank you, you're very kind. These polyphenols are one heck of a mysterious bunch. You can basically design a study to achieve whatever result you want from them because they can do so many things n different situations and doses. Quercetin is even worse, (and now I finally think figured it out...in future episodes.)

[@stlounsbury]

Thank you for this great review of the upcoming data.. I take Quercetin because it’s the only thing in 11 years that stopped my skin from itching insanely from the attacks by SLE Lupus. I’m 63 so a little anti-aging is also a plus especially now.

[@linaaboudheir3878]

Really enjoyed the details 👌💪🏻💪🏻 Well Done Rimon

[@mag4926]

Supplements don't work overnight and certainly not for people who have treated their bodies badly. The starting position is crucial. Friend of mine have been on metformin and NMN for 2 1/2 years and they look shockingly younger than others their age. This is not a recommendation! Everyone must know what they are doing. The mirror doesn't lie!

[@linaaboudheir3878]

Rimon does not talk a lot about Metformin Though I heard Dr D SinClair took it or takes it on & off Hence I get confused should I or not among other Supp

[@revealanation7778]

Great video, well done, detailed and informative

[@zhilahaghbin4766]

Thanks Rimon: I love listening to your analysis, you even make me interested in research:), you teach us how to read and understand these papers, research literacy, hope your wife doing well.

[@jamesthompson7282]

I'm impressed. This guy takes is a careful & very well-reasoned approach to evaluating the available research. I find that's rare in this field. I'm subscribed. Smart of him to consider motivations of the lab, and the various players involved. Interpretation of the data seems reasonable, but it's hard to really evaluate that without seeing the data itself. That said, he's better qualified to evaluate the data than us (certainly me). He even tried to speak to people involved in the study (that's being thorough!). Working out the dosage given in the study: that was brilliant. The rats weren't given a therapeutic dose for cancer clearance! He didn't speak to the mice, of course. I've met some lab rats; wonder whether they deliberately screwed up the results just to mess with the researchers. Bet they're pissed at being researched. . . . . Yes, I'm kidding. Then again, major cause of death in lab rats isn't cancer: it's medical research. Sucks to be a rat. I feel an affinity to them: have had cancer. 😊 My experience? I'm 65. Ditched Resveratrol some time back when I discovered it's counter-productive to attempts to put on muscle. Loss of muscle mass (due to cancer treatment) is overwhelmingly the biggest (hopefully) addressable problem I face at this point. I HAVE been taking low-dose Quercetin though, so I'm looking forward to the next installment in the good doctor's review of the research.

[@boelsevier8346]

Thx for the great video! Latest takeaway, for human: Under ~60 yo? Low dose 30-180mg (.5-3 mg per KG) of Fisetin repairs, extends cell's lifespan. Over ~60 yo? High doses (15-20 mg per KG) to kill off senescent cells which is desirable due to accumulation over the years. Background: Since the human body can't create Fesitin, supplementation of these plant derived compound with food (to increase absorption) can create the environmental cellular stressors needed in our body to either repair or kill off aging cells.

[@WellnessMessiah]

Good summary! The only comment: low-dose fisetin is yet to be proven, unlike resveratrol which I feel 100% confident about. But maybe does work.

[@gregariousguru]

Great video!

[@jasonbromano]

I have finally gotten around to watching this video. What an outstanding piece of work! There was so much interesting information about all aspects of the "crime scene", things I did not know about and clearly did not understand. It's a fantastic reference not just for fisetin but for how the ITP works and how the mouse studies relate to humans. As for me, I've been taking fisetin for a while now. At first I took it every day, but after watching your past videos on cycling I have put it in the category of supplements I do a 5/2 cycle - I take it on work days and then don't take it on weekends (this is also how I cycle resveratrol). My dose is 150mg, which based on my body weight is less than 3mg/kg, and since I'll be turning 47 soon I don't think I'm in the age bracket to go with high dose to clear senescent cells yet. So I think that is considered low dose still, and since I'll be turning 47 soon I don't think I'm in the age bracket to go with high dose to clear senescent cells yet. I think at low dose it tends to promote autophagy within cells, recycling old proteins and organelles to strengthen the cell, but more researchi s always better and needed. One other thing, as with many of my supplements, I take it in liposomal form for the most bioavailable delivery. I don't think there are any studies out specifically on liposomal fisetin, but just based on studies for other molecules I think it's a safe bet that this improves its effectiveness. Hopefully we'll get a lot more liposomal studies on not just fisetin but many other longevity molecules, it's very exciting. Keep up the great work! I'm looking forward to seeing your quercetin video, as I also take that (in phytosome form, which does pretty much the same thing liposomes do).

[@maz.6525]

Great video! I really like to way of explaination

[@bowser2005]

Amazing analysis. Bravo!

[@larsnystrom6698]

A good analysis. But one comment: If ITP had given the mice a sufficient dose of fisetin to kill senescence cells, it would probably had reduced their cancer risk. Thus, if they do the doses right, they should get longevity effects on mice. A correct dosage would be intermittent high dose.

[@WellnessMessiah]

Yes, you're right. They had one regimen of intermittent 3-11 like you sugested - but with a medium-low dose of 250mg which is not enough. Actually, their study is helpful! We know if you take 250mg of fisetin, don't expect senescent cells benefits or any longevity benefits probably.

[@lopezb]

Thanks very much Rimon- makes a LOT of sense!

[@WellnessMessiah]

Thank you for bearing with me through the whole things. Most people it seems just could watch it all to see why it makes sense like you did. Kudos

[@Letsplay222]

Great video. Thanks for the research!

[@WellnessMessiah]

Thank you for bearing with me through the whole thing. Most people it seems just could watch it all to see why it makes sense like you did. Kudos

[@Casey-rr7th]

Great information. Thank you!

[@WellnessMessiah]

Thank you for your comment Casey

[@gprivat812_my_selection6]

👍👍Convincing analysis of this ITP Fisitin study!

[@WellnessMessiah]

You're very kind!

[@user-xk8xr8gs4f]

Great video. Thanks

[@arhu74]

ITP also studied synergistic effects (eg Rapamycin + Acarbose and Rapamycin + Metformin)

[@WellnessMessiah]

You're right. Hence I carefully said "mainly individual" molecules. Good catch.

[@tonycastani1560]

Thanks for pointing out that the ITP senescence trial was so flawed and not translatable to humans. You're the best Rimon!

[@WellnessMessiah]

Thanks, Tony. I think we can still learn from this how medium-dose fisetin affects other things in our bodies. You know, 250mg - does it keep any tissues young similar to resveratrol?

[@stlounsbury]

I think the study does translate to humans given out great grandfather from 900 million years ago, and the study wasn’t actually flawed, it was for one supplement only, at a time, and was used on those little soldiers when they were to young to fit the criteria.

[@melkor321]

Very interesting video.

[@stephenwillis9571]

Thanks for the video - I would like to explore further the factor conversion rates and the issue of threshold to induce senescence. Given its low dose occurrence in nature, that would suggest that the senolytic properties are accidental - since those doses would never be attained. It is also theorised that senescent cells might suppress tumours - so perhaps in a species prone to cancer it might not expect to be life-extending. A deeply to hear of your wife's stroke and wish her a full recovey. One of the few fisetin human clinical trials was to extend the therapeutic window of Ischemic stroke patients, when used in conjunction with the stand of care treatment. "Fisetin Prolongs Therapy Window of Brain Ischemic Stroke Using Tissue Plasminogen Activator: A Double-Blind Randomized Placebo-Controlled Clinical Trial" There has also been some time ago, based on searchable article below, speculation hat c60oo might be useful within a time window to aid stroke recovery: "Nanoparticles reboot blood flow in brain" I would have thought that fasting would be a possible approach to aid stroke recovery - there is a good talk by Mark Mattson on fasting and the brain. All the best.

[@davidwelburn]

I almost never subscribe to a channel, but I am subscribing to yours. Excellent job. Just one question - why resveratrol rather than pterostilbene? Also, very sorry to hear about your wife having a stroke.

[@tenzindolma6266]

I personally am taking both, as they help one another work better.

[@davidwelburn]

@@tenzindolma6266 Thanks, I never heard that.

[@tenzindolma6266]

@@davidwelburn I learned that reading a presentation of Pterostilben

[@monnoo8221]

if we would be held nicely in a cage, we would not die from CVD or diabetes or alzheimer. We die from infections, mostly lung, at the age of 100..120, because the immune system runs out of stem cells. Or of the weakness implied by energy deficit caused by the CD38 path, which gets triggered from unspecific immune response. As mentioned earlier, longevity research with mice have to be done precisely on strains that have the same immune condition. Hence fighting inflammation above the age of 50 is key. And certainly fisetin helps here. about the ITP "multi-center" study. they say, that they try to replicate the results in 3 research centers. A multi center study usually does NOT evaluate each branch independently. It is only a part of the analysis. If however you find 3 imes a significance of 0.06..0.08, missing slightly the 0.05 that is a strong indication that the N was too small, and hence the studies not properly designed. In such a situation, a meta analysis INDEED would find a SIGNIFICANT result. Well, for me the ITP is not trustworthy at all. They have a hidden agenda, clearly recognizable by the sarcasm of Mr.Miller in the interview.

[@fatboydim.7037]

Hey Rimon you should post these two videos to Brad Stansfield and let him consider what you have uploaded. Dr Brad was happy to dimiss reseveratol as well.

[@WellnessMessiah]

Hi, Brad commented on my last video and I replied inviting him to make a response video. A year ago I also tried to collaborate with him unsuccessfully, too.

[@Battery-kf4vu]

TMG raises IGF-1. Some studies have shown it is good against sarcopenia, but what about longevity?

[@charlesgreen7408]

Thank you very informative, plan on reordering and take ever quarter for 3 days at high dose for healthy 67 year old 5'8, 175lb 5 to 7 miles fast walking 5 days a week, sprinting 🏃‍♂️ part of 2 days of the 5 days.

[@WellnessMessiah]

Sound like a good plan with yoour decent exercise Charles

[@spuzzum100]

Thanks 👍

[@Christina_Yang1217]

Will it help if my cat has a tumour already? I am giving anti-cancer drug to my cat already, can Fisetin help in this situation?

[@user-fo2cc7xx4y]

Is fiesetin effective with chemo? (Folfirinox)

[@jenxsj3902]

Rimon, I loved your video. Fisetine? Not sure but Quercetin is a stable. I think Fisetin will get into the same loophole as Resveratrol.

[@weiminyang7206]

Rimon, I loved your video too.

[@WellnessMessiah]

@@weiminyang7206 Thank you

[@WellnessMessiah]

Thank you

[@peterz53]

On the Fisetin calculation, there is also the biological half life issue. Taking it in food over the course of a day vs a bolus may make a large difference, especially when the mg/kg dose is not adequate. Half life in mice seems to be around 3 hours. Could not find for humans. Q half life is a lot longer. So, not only is the matrix in which F is delivered important (Fat and Pepperine present ?) but the peak concentration at the senolytic cells. I'm over 60, so I take the Kirkland dose for 2 days but divided into two doses with a small mount of food with both fat and pepper. I do the same with Quercetin but 3 weeks after. Total cycle time of 6 weeks based on Kirkland comment about time for SCs to come back. I would take F and Q as one daily dose, but am wary of toxicity even though they seem to be safe.

[@KasKade7]

Highest food in fisetin= strawberries Highest food in resveratrol= dried mulberries Highest food in quercetin= capers Now starting making a salad with these and add some olives. But you're still going to die way before someone with longevity genes. Enjoy! ;)

[@harborgirl8877]

He also just posted videos speaking about NOT taking Reservatrol, and now NMN. I am leery about Stanfield.

[@RJay121]

You should be more leary about Sinclair, don't trust anything he sells😮

[@livingsmart]

TL;DW: more research is needed

[@bq3538]

How do you review exploration? Who reviewed the New World before Columbus discovered it

[@scottishfoldmocha5875]

1:24 - the other substance is antibiotic Azithromycin, just 1 dose removes approximately 97% senescent cells

[@Mark4Jesus]

41:55 WM: "Does that make sense to you?" Me: "Duh, huh?"

[@DCGreenZone]

The Fisetin and Quercetin in LE's Senolytic Activator are cut from a different cloth. They are phytosomes that have the ability to pass the stomach intact. Dr. Brad needs to read more and pontificate less.

[@jonathanmagic5633]

pretty sure Dr Brad Stanfield is just a GP with minimal experience so not quite sure why he's going around criticizing scientists who spend their lives studying this stuff.

[@davidderidder2667]

It is mind-boggling really. And the energy that man has to make so many detailed videos

[@baileystruss7319]

What about fisetin bioavailability?

[@WellnessMessiah]

It's hard to track these molecules. A lot of the action actually comes from their metabolites. Hence the best strategy is to look at the end results, assuming we can't track their full activity perfectly.

[@baileystruss7319]

Thats a good point and I've also read that their interaction with the gut microbiome might be as important effects as their serum levels.

[@deanz9161]

Rimon I don’t know your background but you could teach at a college for sure!

[@Sandy-bm9qc]

I am 70 year old female and started taking low dose resveratrol and 1,000 mg nmn daily. How much of Fiesitin would be best for me ?

[@WellnessMessiah]

it depends on your goal. For targeting senescent cells, I've showed you what they are using in the studies in this video (around minute 30 I believe)

[@semaaral2498]

Yes, I like to know this answer, if I may pls. When you say low dose, what mg shall we talking about? I tried low-dose Resveratrol. Does it makes cancer cause I’m scared but at our age, nothing happens so made a 500 mg dose every day since last June. Thank you Looking forward to hearing from you. Thank cw you🙏🌹

[@semaaral2498]

Thank you👌🌅🧿

[@felicisimomalinao1981]

High dose fisetin may ma toxic.

[@lorenzotrombetta6887]

Please don't ruin the seriousness of the channel with these dumbfounded guy images (0:10) I know it's difficult but try to shorten the videos keeping all the info. You repeat yourself sometimes

[@WellnessMessiah]

I thought it was funny, I just like this guy in the photo. Hopefully, he didn't destroy for you the whole thing.

[@ash9x9]

That dumbfounded guy images was really off-putting...

[@felicisimomalinao1981]

In case of doubt, don't spend on doubtful supplements. The ITP study should be repeated by other labs. So, I am taking luteolin, apigenin and Fucoidan - as no research show any doubt. Anyhow, thanks Rimon for your meticulous video.

[@carlmerlin5599]

44mg of per 1kg(1000000mg) ppm

[@WellnessMessiah]

Should it be 48? 600/12.3

[@VM-oi3dk]

Healthy mice are not representative of the vast majority of unhealthy humans, lol

[@newyorkskier]

Mr Stansfield (I am not sure if you are a real doctor, so I will call you Mr. You have not posted your diploma or c.v online). Fisetin failed in the ITP trials because they use a mouse strain that has very little senescent cells to begin with. They should have first checked the level of senescent cells and see if it compares with the levels in other strains. The whole study was humbug

[@keithhaken172]

Enough with the evolution nonsense. Proven mathematical impossibility.

[@gregariousguru]

Notice later, he's giving "nature" a mind , however 🤔 .....still waiting on this theory of nature..