Should you take Vitamin K2 for Calcified Arteries & Heart Disease?

[@justgivemethetruth]

Exactly why I listen to this channel - so many health and nutrition channels just make stuff up or get it wrong, NMS sticks to the studies and where there are disagreements, explains them. Thank you.

[@trumpetingangel]

Thank goodness for you! Whenever I see new nutritional claims, I turn to your channel and ignore what's trending online!

[@darrellshuman7751]

The K2/D3 conversation is one I would like to see. I take K2 because my PhD at Google University taught me it has a synergistic relationship with the D3 I take daily.

[@ShazWag]

Same. The University of Google taught me that vitamin K2, specifically MK7, would reduce the risk of a potential heart attack through increased calcification of the arteries from taking vitamin D3 alone. Now I'm confused 😐

[@xiamengbaby]

I've seen from a dietician that magnesium should be taken with D because so many people are low on magnesium and that it is needed in the assimilation of the D.

[@Bloozguy]

A few years ago, I went strict keto. Under the close watch of Dr. Google. Not sure if that K2/D/Mag routine I've being doing the past 5 years is working or not. Don't care. It either does, or does not. If it does NOT, then I didn't want to find out the hard way by not taking it, since it really wouldn't really matter either way. If it DOES, then I can chalk it up to just plain luck or it didn't matter in the 1st place. There does seem to be people making big claims about K2. Is it worth not taking it? I'll ask Dr. Google & report back.

[@shawnsanborn2057]

@@pohaaseems like a lot of k

[@pohaa]

@@shawnsanborn2057 there's no upper limit of K, especially K2 which has many benefits, such as preventing and treating atherosclerosis. It has also been shown to reduce the risk of prostate cancer and may reduce calcium build up in the brain, staving off dementia etc. Have a look into it 👍

[@HawkeyeFan321]

Merry Christmas! I very much appreciate you and the effort you put into educating others

[@yo25999]

Can we just get a vitamin d3 + k2 video in general? You do it better than anyone else.

[@hiit-itxr-fitness1962]

Let’s add magnesium into that mix

[@deel2435]

@@hiit-itxr-fitness1962 and calcium. If we're talking bone health vs heart health we need a breakdown of all of it.

[@hiit-itxr-fitness1962]

@@deel2435 True, but of the three, Calcium seems to be the least underestimated. If anything, it's overstated

[@deel2435]

@@hiit-itxr-fitness1962 I don't agree, especially for us health conscious women. We tend to not get enough calcium in our diets.

[@Nobody-Nowhere]

@@deel2435its better to get it from your diet, you can get way too much from supplements.

[@oksanakaido8437]

I take K2 along with vitamin D and calcium supplements (for osteoporosis) on the reasoning that it will help the calcium actually get to my bones instead of staying in blood vessels, so was hoping to learn more about the research on nutrition and bone health.

[@jerrihardin9557]

I had to quit taking calcium supplements, because calcium deposits have started showing up in soft tissue areas, namely, breast tissue and abdominal arteries. These were obvious on x-ray examination & mammogram. Getting adequate calcium from food sources is not the culprit here, though. I took supplemental calcium all throughout my adult years, but was not getting adequate magnesium, D3, or K2 with MK-7, for that matter! Since I have stopped calcium supplementation, I am looking forward to getting new scans in the near future, to see if the calcium deposits have decreased. If not, perhaps new deposits will be arrested! We have been duped into thinking we need all this calcium supplementation, when most of us really don’t; and, it is actually doing more harm than good in most instances! And yes, I eat lots of Greek yogurt and green,leafy vegetables to get my calcium from food sources. I suggest that you should stop the calcium supplements altogether.

[@wyattfamily8997]

@@jerrihardin9557 I agree, calcium can be dangerous to artery health.

[@NNancy-n1g]

I had to stop taking calcium and vitamin D supplements because my calcium levels were high in my blood.

[@oksanakaido8437]

In general, I agree with what you all are saying here, I'll take calcium occasionally for a period of time, but don't feel comfortable with taking it every day for an indefinite period of time. Doctors seem to consider supplements absolutely harmless and don't care much about monitoring their levels. For instance, my endocrinologist thinks calcium is the holy grail for osteoporosis, while all the other complementary nutrients don't seem to concern her much.

[@seascape35]

@@jerrihardin9557 Would you mind sharing the amounts of Calcium supplementation you were taking?

[@DANGJOS]

I would definitely like a discussion on vitamin K2 on bone health and hip fracture risk overall. It would also be interesting to know whether it matters if you use MK4 or MK7.

[@jedi-mic]

Just take Nattokines

[@DANGJOS]

@@jedi-mic How would that help with bone health?

[@melvillejayathissa7415]

Vitamin K2 as MK7 !

[@melvillejayathissa7415]

​@@jedi-micNattoKinase?

[@jedi-mic]

Is that the same stuff ? is that how you pronounce it?@@melvillejayathissa7415

[@jacobrpince2000]

Hey doc! New mic is great, however it initially seems worse due to the extra room sounds picked up as echo etc. from the higher quality mic. I have a minor in music tech, alongside my major in bio, but as a scientist I’m sure you’re fine looking this stuff up! I’d gladly help if you want it, but if you did some research into “gain staging” I think that would provide the most benefit to you! That way you can pick up less room and more Gil! Hope this is helpful and not annoying! Thanks for making the highest quality videos on KZbin! Jacob Prince

[@NutritionMadeSimple]

thanks! very helpful. will try to turn down the gain a bit and elevate the mic to be closer to sound source. feel free to msg through the FB page too with more feedback! thanks

[@denniswills8788]

Im 70 yo and have been taking D3K2 for 3years, i done a calcium score and was surprised i had a score of 0. IM not sure if it was k2 but i was happy with the result as only 5 percent of people my age have a score of 0.

[@VikingsFan-iu5kq]

What was your score before the Calcium score ?

[@johnq6361]

Hi, same age here, & I also have been taking MK7 and D3 for about 3 years now, but it's not so easy to get a scan here in Canada,( unless its through a cardiologist.) How much do you take per day? And do you take other supplements like nattokinase?

[@rdmckeever7645]

Have you found much K2 research on bone density when combined with D3 supplementation (with or without resistance training)? Cardiovascular disease is obviously important, but, bones are handy too...

[@Themata]

And hands are bony 😅

[@deel2435]

Agreed, along with Magnesium because without it you're simply depleting your Magnesium. If supplementing D3 you really should make sure you're consuming enough Magnesium and don't over do the D3.

[@GreenTea3699]

I had unknown bumps and growths for years on my shins, hands and other places. The doctors were still stumped after several biopsies and i was told it was a mystery. After taking K2 for other reasons the bumps started disappearing. I take K2 with D3 daily and the bumps have not come back

[@jerrihardin9557]

Do you think these bumps you had were lipomas?

[@GreenTea3699]

@@jerrihardin9557 I don't think so. They were hard and bony

[@nicholemenard1274]

Interesting, I have developed some bumps on knuckles, was told they are bone spurs due to osteoarthritis. They are starting to disappear and I started taking k2 with D3 about 3 months ago. I wonder if there is a connection.

[@imthinkingthoughts]

⁠@@nicholemenard1274how much k2 do you take?

[@ÁzsiábaSzakadtam]

Anything that Berg, Ekberg and the likes recommend needs that grain of salt which can only be found in Gil's kitchen.

[@kristofkozari9040]

Akartam javasolni Önnek ezt a csatornát, mert számomra laikusként is egész megbízhatónak tűnik. :)

[@discbee9107]

Thank you for this honest opinion… another great and very helpful video. I was hoping evidence was more compelling, but I guess there’s always hope… hope that more extensive research is done in the future with better results.

[@gabymalembe]

I had a high calcium score 12 years ago (1188) and I’ve been taking K-2 since then, and haven’t had any “events”. No way to know if the K-2 is the reason.

[@elsagelympne7943]

What's your calcium score now?

[@kinpatu]

At 5:10, I’d point out that raising HDL, pharmacologically, doesn’t improve outcomes. Raising it by other means (e.g., exercise) does improve outcomes. But the point is well taken: HDL is a marker, not a causal agent.

[@stevenmiller7747]

Based on studies I’ve seen no evidence that people with low HDL raising it by any means (medication, exercise, alcohol…….) does nothing to reduce cardiac events. If you have any links that contradicts this I’d love to see it.

[@bartcop2742]

K2 helps with getting calcium to the bones, so it's still helpful in that way

[@David-tu4ub]

That's where it should go not in your Arteries

[@tomlongam7653]

Many thanks for this video! I wrote to you on this a long time ago because I was curious from what I had read! Many thanks for this summary!

[@cherylcampbell7495]

I’ve taken it for the last six months . Raw k-complex. My chiropractor recommended it for my spinal stenosis. Actually has dissolved a lump on my right wrist. Also started taking peptide collagen bovine for energy. I’m 75 and feel like a new person.

[@stevenlaake9975]

What about the 3,000 years of trial that Japanese have less heart attacks and possibly lower BP. That was traced to the fact they ate natto. Which has extremely high levels of K2. I think that should also be talked about.

[@kathleenking47]

I like it, but it's an acquired taste. Not all Asian markets have it Or like it

[@gpalzz1121]

I've been a lifelong trail runner(more than 50 years now) and I had my calcium score done - about 5 years ago and it was 330 ( ish). I've also found research on senior athletes with ( what they termed as) hearts of stone. The gist of the reasearch was that cardio respiratory fitness was the key metric. The higher the level of CRP - even with elevated calicification scores - the rate of events for those with the highest levels of CRP was far lower than non-fit controls. I've done a google search on hearts of stone to find the various research papers. I would love your take on it. Guy Palmer, Mill Valley ca.

[@gtkona1608]

Hi Guy. 30 year Ironman world class age group athlete here, Kona 29 times. Calcium is thought to represent only 30% of the total plaque burden and it is the non calcified plaque that poses the risk of MI. With a calcium score around 200 I had a CT angiogram of my coronary arteries done in my mid 60's. The only plaque present was the calcified plaque. My cardiologist says that there is anecdotal evidence that endurance athletes tend to calcify plaque that non athletes would not calcify meaning that we have a lower amount of risky soft plaque than our calcium score might suggest. Also, by CRP do you mean cardiorespiratory fitness?

[@fortworthron]

@@gtkona1608 I suspect he means C Reactive Protein - another test (for inflammation I believe).

[@naughtyorgneiss]

​@fortworthron no, he means cardio respiratory fitness, no way its crp. Higher levels of inflammation are not healthy.

[@calebwert1057]

Merry Christmas Gil!!!!!!!

[@DANGJOS]

I imagine that eating natto is overall a good thing. Not only does it have vitamin K2, but it also has some nice probiotics (to my understanding)

[@viviandarkbloom8847]

oh yes, and if you like East Asian food, give kimchi a try, as well ;)

[@albineg]

Natto contains a lot of beneficial compounds like PQQ and Nattokinase, good amount of calcium also for a non-dairy source

[@raybar1915]

Thanks for the information. I would be interested in hearing your assessment of the evidence of vitamin K2 on bone health. There is some evidence I have seen in the literature that shows benefits of K2 supplementation but it seems like some studies show benefit and others do not.

[@pietrocantuccini5584]

Arthritis & Osteoporosis doi: 10.1155/2017/6254836 CVD & coronary calcification doi: 10.1155/2017/6254836 + DOI: 10.3945/an.111.001628 Coronary Heart Disease DOI: 10.1093/jn/134.11.3100 Dental Caries doi.org/10.1016/j.mehy.2015.01.011 Inflammation doi.org/10.1016/j.diabres.2017.11.020 Osteoporosis in Rheumatoid Arthritis DOI: 10.1016/j.maturitas.2020.05.020 Rheumatoid arthritis DOI: 10.12659/MSM.911628 + DOI: 10.5414/CP203827 + doi.org/10.1016/j.ejphar.2015.06.014

[@greggarlough8955]

Would like a discussion on your thinking as to which supplements you feel would be appropriate for the general population.

[@Blurred1-h9f]

If you are fully or almost plant-based, then Vitamin B12, Vitamin D (almost everyone could take it during the winter season) and maybe Omega 3 depending on your nutrition composition

[@pietrocantuccini5584]

The 'general' population (age 20-50) doesn't need supplements, except vD in Winter.

[@Blurred1-h9f]

The "general" population is anything but health conscious and they almost certain have one or more deficiencies in vitamins or minerals.@@pietrocantuccini5584

[@Ronlawhouston]

Great video Dr. Gil. Okay a little comment on evidence. On the observational side, the Japanese consume a lot of nato and seem to do well with longevity and heart disease. I am not certain what inferences you can draw from that observation. On the anecdotal side, I take K2 supplements. I have calcified plaque but I started taking it to regulate and mobilize calcium in the body. I had to get dental implants. My dentist has been monitoring the recalcification of my jaw bone and is amazed at the results. So my theory is that K2 is beneficial for older people to help regulate and mobilize calcium. I have also noticed that I have less problems with calcium deposits on connective tissues. I am really debating if you want to try to reverse calcium in the arteries. I think I prefer having stable calcified plaque to unstable soft plaque. Again, thanks for your work.

[@georgecav]

So you may stop supplementing K2 to keep stabilizing Ca in the arteries?

[@embarq12]

In case of a high CAC score, it could be a good idea to get a CTA scan to detect soft plaque and also measure APoB to assess future risk before any intervention.

[@Hanover-ek4jy]

A CIMT test will also identify soft liquid plaque!

[@B-the-Ball]

This is my situation, high cac score 596 5 years ago. Primary is adjusting my statins to lower ldl. Cardiologist had me do a nuclear stress test (twice) passed flying colors. Neither doctor mentioning CTA but learning about it on my own. How to go about getting this authorized.

[@4plum]

Measuring ApoB is under $20 if done through a private lab in the US - knowing your number is a no-brainer.

[@marilynkonstapel403]

I read that K2 in combination with D3, instead of just D3, can help get more calcium to our bones, especially those of us who might have ostopenia or osteoporosis. I would like to learn more about that. So, not a focus on heart health, but a focus on bone health

[@Jesse47249]

He liked a comment asking him about this. So, I believe he has the intention of doing a video soon about vitamin K2 and bone health.

[@marilynkonstapel403]

Thank you. I hope so@@Jesse47249

[@pietrocantuccini5584]

What you've read is correct. K2 activates the Matrix-GLA-Protein that was mentioned in the video. Whenever you want to add it to your regimen, make sure it is of the (K2) MK-7 variety.

[@xiamengbaby]

I've also seen from a dietician that it's important to take magnesium with Vitamin D. So many people are deficient in magnesium and that it's crucial for the absorption and assimilation of the D.

[@Fitzrovialitter]

I read that the moon is made of green cheese.

[@sandraann5496]

Thank you so much for breaking down and explaining the research done on so many areas of health and nutrition. Could you please do a video on turmeric and the benefits and dosage of this supplement? Thank you.

[@MrSinister718]

He said a whole lotta nothing!

[@kevinstarski1598]

Like he usually does :-) @@MrSinister718

[@mingkee27]

I noticed my fingernail is less prone to break. Vitamin K2 actually works along with D (D3)

[@sectionalsofa]

For me it's complicated... but not so unusual. Firstly, I'm 70. Having an autoimmune disease, I find it important to take a fairly high dose of vitamin D (8000 to 10000) to keep my levels in the optimal range (around 60). However, I'm aware that doses above 4000 can drive calcium out of the bones and into the bloodstream. I already have a CAC score of at least 42 (tested 5 years ago) and am taking a PCSK9i. But my main concern is that my mild osteoporosis will worsen with that high dose of D possibly driving calcium out of the bones. So, to be safe, I include 200 mcg of K2 (MK7) in the hopes that this will enable the vitamin D to keep the calcium where it needs to be... in the bones. I know I'm not alone in this. As they say, aging is not for the faint of heart. By the way, anecdotally, I do find my dental checkups have improved markedly. Thoughts?

[@Julottt]

No, taking a very high dose of "vitamin" D (an hormone) doesnt drive calcium out of the bones into the bloodstream in itself. What does that is eventually having a too high blood "vitamin" D lvl long term, a toxic lvl above 100-150 ng/ml which could be reached by most people from taking 5000-10000 IU of "vitamin" D daily in a few weeks or months but obviously you and me need to take more than 5000 IU daily to reach a healthy to optimal "vitamin" D lvl in the blood. This is why the limit recommendation is set at 4000-5000 IU daily.

[@1truemoose]

I take K2 MK7 and my dental checkups have improved too.

[@melvillejayathissa7415]

Same here, less pain during drilling, and at age 76 now I have just switched from a combined supplement of Vitamin D-3 with 5,000 IU and 180mcg of Vitamin K-2 after 3 years since COVID to 10,000 IU of Vitamin D-3 and 300mcg of Vitamin K-2 both manufactured by NOW FOODS. Hope this helps somewhat! Melville from sunny Malaysia

[@tonygordon7571]

"I'm aware that doses above 4000 can drive calcium out of the bones and into the bloodstream." Is there evidence that taking vitamin D over 4000 IU causes that?

[@gmw3083]

I'm growing new enamel with K2

[@jedinxf7]

thanks so much for this. i never imagined that calcification could be a protective effect revealing a problem rather than a problem (or progression of a problem) to solve

[@susanbeever5708]

Calcification is a marker for vascular smooth muscle cell (VSMC) inflammatory phenotype that causes osteoblast-like cells that lead to calcification and a dangerously thin fibrous cap that can lead to plaque rupture then myocardial infarction and stroke. From 2020: Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate Complex SMC Phenotypic Changes Critical in Late-Stage Atherosclerotic Lesion Pathogenesis Too high carb/sugar-> too high TRPV1-> hyperinsulinemia-> more TRPV1-> hyponatremia/hypoosmolality -> too much TRPV4 in VSMC with Klf4-> switch to VSMC inflammatory phenotype. Hypertension can also cause too much TRPV4.

[@arc0006]

Interesting. I heard berbrine can effect calcium channel scores. Funnily enough I heard this in a youtube video and in the comments someone mentioned that is a bad idea. I think they might have been referring to the soft plaque ruptures like you mentioned. So my first question to you is berbrine and the heart? Probably not enough data yet but your early thoughts would be appreciated. Back to K2 there is a study showing low k2 levels is one of the causes of prostate cancer. The coles notes version is that men with low k2 levels had varicoles(sp?) exiting the prostate which had a retrograde flow of blood saturated with DHT way way above normal. If I remember correctly the study or a other study showed supplementation helped reduce the risk. Men that had the varicoles removed early did not get prostate cancer. Incidentally I asked my doctor about this and he was concerned about k2's blood thinning effects. *shrug*

[@kelvinyu339]

Which form of K2?

[@arc0006]

@@kelvinyu339 I don't know. I will have to go look.

[@peterholt4806]

Your video showing a plaque stopping blood getting through surely explains the calcium problem. Calcification is "hardening of the arteries". Without "hardening" the arteries is flexible and pliable. So any narrowing by plaque will not significantly affect blood flow as the artery will dilate to allow flow, unless it is calcified and stiffened.

[@NutritionMadeSimple]

there is some truth to this as arteries can initially dilate to compensate for stenosis (they call it "positive remodeling"). unfortunately, there is a limit to this and plaque eventually starts to bulge into the lumen. the other relevant aspect is that most events (heart attacks etc) arise not from plaque completely blocking the lumen but from plaque rupture + acute clotting. interestingly, this often doesn´t happen in the largest plaques. calcifications may help prevent this as they strengthen plaque

[@directajith]

So calcification can be bad and good​@@NutritionMadeSimple

[@01jausten]

Could you please say if the study participants are male or female and if the females are pre or post menopausal? I ask because, as you know, most studies do not have female participants or they are not split into pre or post menopausal females. This is so important for the public to understand what effect this has on women’s health.

[@-fred]

What is the optimal proportion of vitamins D3 to K2(mk-7) for bone health?

[@HowardKlein1958]

I take 100ug of K2 mk7 with 10,000 IU D3.

[@budte]

@@HowardKlein1958 10,000 is exceptionally high. D3 is stored in the body. Your doctor can give you a simple blood test. The lower end of the normal range is supposed to be desirable. I take 2,000 D3 and 400 MK7,.

[@larryc1616]

Vit D + K2 + nattokinase = ❤

[@LoiolaALG]

Add Ubiquinol, Acetyl L-Carnitine and Tocotrienols to those for even better results. While at it, add Glycine, NAC and Taurine.

[@parisryan1122]

What about Nattokainese? Love the science based evidence!

[@playfulpatyy57]

Read plus things on natto and if not appropriate does no difference? I have heard nattokinase can be hard on stomach. At high dose 8,000 I had bad acid reflex. Whether that or something else, not sure?

[@TheParadigmShiftTV]

Thanks for tackling this issue. I see you have a new microphone but it doesn't sound like it's on? Is it connected to your camera with the correct settings? Sounds like the audio from the camera without an external mic. I recently used a wireless mic connected with a USB-C cable but it needed a mic phono cable to work. The USB-C is for transferring files from the mic to a computer.

[@Teneab]

What about Vitamin K1? I think it would be fitting to address that in the video.

[@teddybearroosevelt1847]

Yes, i agree

[@contact2001]

Just eat your Greens, they are full of vitamin K your body produces all K2 it needs from it…. Dr Greger did a video on it nearly a year ago…

[@lealee-healthyteame184]

K1 is for blood clotting, not the same.

[@rn5697]

With what other vitamin should we combine K2? Is it good with D3 and magnesium?

[@budte]

Yes.

[@Teneab]

Maybe do a video about epa-dha/fish oil in relation to heart disease

[@krisvette5874]

Great insights based on the current evidence.

[@heidisunshine2003]

Great information ❤ Happy new year Dr Gil 🕊️🕊️

[@DarthNoshitam]

What if I am taking high dose vitamin D?

[@larryc1616]

Don't. It's fat soluble which means it'll store the excess and eventually cause an overdose. Follow rda for your age group or health condition

[@nelsonace9703]

When taking over D3 10000IU daily, then you can K2....

[@nelsonace9703]

​@@larryc1616really are we sure ? The actual studies I've seen don't reflect this. In fact they gave hospice paitents 300000IU for 8 months with NO negative effects, and I believe an increase of 0.2 of potassium ( or Calcium) in the urine. Another study had around 45K and a whole 7 people had some nausea, blotting...some of the negative data comes from D2. Toxicity is soooo rare and hard to achieve that it took mislabeled supplements ( can't remember exactly but something like over 500000IU for almost 2 years before the dangerous nausea, vomiting happened..look this up

[@TheTigers00001]

Thank you for your balanced approach to this subject. On a lot of other videos posted the comments from the general public border on ludicrous. They say their doctor knows nothing about supplements. However as you point out, when you look for REAL scientific evidence in large trials, there is nothing that supports their use. That’s not to say they don’t work at all but it says that there’s currently no evidence to say they do. Well done!

[@2005kpboy]

Should we not ?

[@mikewazowski489]

Thank you for this video!

[@patricknowlan4590]

Thank you! I love how you cut through BS and tell it like it is. One of best health channels on the internet.

[@richarddobreny6664]

What I have learned is that no one vitamin/supplement can work on its own. Exercise, balanced diet, reduction of sugar intake, a bit of intermittent fasting etc all work together to make you healthy.

[@SpeCialeDDoC454]

"Where do we get these placebos?" "Maybe there's some in this truck!"

[@brianmoran1968]

Thanks for the information

[@tonyc2489]

Thank you. You have touched on a subject I have often wondered about. If calcification forms as a defence of the artery walls in areas of plaque, is it a good idea to try to remove it? K2 doesn't get rid of the plaque, just the calcium. I have taken K2 as a precaution for a couple of years although, probably like many, I have no idea if I have arterial plaque or not. ( I have noticed that the painful swellings on the knuckles of my hands that appear overnight have stopped).

[@Eli-jx8lu]

Have you ever found out what was the cause of the painful knuckels? I

[@tonyc2489]

@@Eli-jx8lu No, my friend, I have not. I thought it was a gout or rheumatoid type of thing but blood tests show neither. I just put it down to inflammation, triggered occasionally (by ?) and try to avoid that with lifestyle and diet. I think it may be a large part due to genetics as my mother and older sister had distortions in identical fingers.

[@shar7508]

Doctor, are they any studies on PubMed re Vit K2 and arterial calcium?

[@susanstarker1378]

Please do a segment on vitamin K2 and bone health, including research, if any, on proper dosage of K2. Thank you!

[@tammylynnlaws8824]

Where do you buy your vitamin k2

[@petervafeades4095]

Density vs score: Higher calcium density is beneficial since it secures hot plaque, lower scores MAY mean lower density which is perilous. BUT a lower score when density is unaffected is a major factor in reducing risk of an event. A Budoff paper found greatly reduced risk for scores that increase by a modest amounts yoy. I lost a lot of weight and was on K2 for a year when I saw a reduction from 409 to 339 in my CAC score while on statin therapy. My plaque burden droped precipitously. Did the K2 help? My joints definitely indicate that there was an effect!

[@enabl3r]

Really love this video!! I’d like to see though how *naturally-derived* K2 (like directly from natto) figures into this. Such as how the Japanese who consume lots of natto are found to have low rates of heart disease. Then how this relates to K2 supplements that are natto derived as opposed to other forms of K2…

[@JBSbass]

lived on natto every morning in the town of Matsushima Sendai for years, it was the go to for the much required pick up needed after a night drinking hot sake in big groups. Its believed to be anti-inflammatory, after getting used to it I would stick a spook of vegemite in it and gulp it down.

[@brokko_le3]

@@JBSbassThat sounds like a more potent morning booster than the strongest coffee :)

[@hevesat1920]

@@JBSbasscan we make it without a starter. Because I can not find a starter in my country

[@k.h.6991]

Natto is a whole plant food. That's going to contribute to health effects, over the K2 supplement.

[@alleneverhart4141]

So I need to take calcium with salt!?

[@peterz53]

Would be interested in a study that used K2 in conjunction with two other arms - standard American diet (which has probably been done) and healthy diet which brings lipids into line and see what happens over time. Both arms starting from same place with known plaque and calcification. I eat a rigorous plant based diet (lots of greens) and have good lipids, but I do take a modest dose of K2 to help assure proper calcium transport occurs Started 11 years ago after being diagnosed with CVD. I rely on diet to control lipids but will likely go back on a low dose statin. Taking supplements without cleaning up diet and normalizing weight is a fools game.

[@markaldridge5089]

I agree with your conclusion. There's so much information out there and there is a natural tendency to focus on a particular food or supplement etc as the "solution", when the much larger issues weigh greater in the mix. So clearly, someone who eats an unhealthy diet, is overweight, does little to no exercise, smokes, drinks too much and has poor sleep has the "solution" right there - tackling any one of these will have a greater effect than any particular supplement. Tackling 2 or more even better. All of the above sorted - boom, massive benefit. I do often have moments of guilty clarity when I realise I have been scrolling through endless videos on supplements etc for an hour, when I might have been better off going out for a long brisk walk instead.

[@choma82]

Can you make a show proving the utility of statins in preventing chd?

[@fatboitino2]

I’ve seen people improve their plaque, but- as far as lowering incidence? No way without a broad and extended study

[@boblablaw4857]

Great content, as usual. I would be interested in seeing your take on Dr. Brad Stanfield's vit k2 recommendation. In one video he does mention the calcified arteries stuff, but in another video he references something related to bone calcium deposition? I can link them if you want, but they are easy to find on his channel. I respect both of you a great deal, as well as when we get to see Professor Gardner. So hard to get good information on this stuff, so thanks again :)

[@BlueSparkshine]

My aesthetic medicine doctor recommended adding k2 to d3 to prevent/slow facial bone loss. Can you comment on the validity of this?

[@mger1979]

The problem is that vitamins does not prevents anything, however the deficit of them causes issues. And this is true for any vitamins. For instance If you have deficiency of D you will get issue with bones, brain and even arteries, however If you have enough vitamin D, there is no guarantee that you will not have issue with bones, because besides vitamin D you also need tons of other minerals vitamins and nutritions to be healthy. And the same for any other vitamins. And from this point of view, instead of conducting a study on the effect of an overdose of vitamin K, it is better to study a group with insufficient vitamin K levels compared to a group with normal levels.

[@shar7508]

What supplements should ppl with osteoporosis take? And how much? They will need more minerals than a person without osteoporosis, correct? And what diet? Thanks so much!

[@Vincentorix]

How does calcium channel blockers like amlodipine for hypertension fit into all of this?

[@cdprince768]

I appreciate you sticking with the numbers for evidence of efficacy, yet you don't seem to do that with statins. Meta-studies have clearly shown that the absolute risk reduction from statins regarding heart attack, stroke and death are 0.9%, 0.4% and 0.5%, respectively. This means that 982 people out of 1000 get no benefit from statins, which in turn means statin benefits are not statistically significant. Yet you continue to advocate for statin use.

[@NutritionMadeSimple]

hi, we have a video with complete coverage of the RRR vs ARR question: kzbin.info/www/bejne/rIO1dWukjaqsfa8

[@bcc1955]

Yep, the bottom line is increased survival. Thanks for video pointing out this fact.

[@InfiniteLynn]

I started taking a D3-K2 supplement a few years ago because I read it helps prevent dowagers hump, something both my grandmothers had. I'm going for a CAC test this week because I have high LDL cholesterol (I do low carb) and my doctor wants to put me on a statin. I pushed back, hence the test. No, I don't normally second guess my doctor and I don't think it's generally a good idea to do it, so I was happy to hear you warn against it. If my CAC test has a high score I will next ask about the CIMT test for soft plaque.

[@acke26]

Is K2 increasing the risk of clotting?

[@markkubert8572]

Do we have any idea how much calcium has to be deposited to stabilize a plaque? Once that level of stability has been reached does calcium continue to be deposited and arteries are hardened? Would reducing calcium then be a good thing?

[@rodenwald]

That is exakt my question. And does K2 destabilize the soft plaque, which is a big risk?

[@lorettawitomski9806]

I have Osteoporosis. I read that I should take K2 as MK7. Is this true? Is it best to get it from eating Natto???

[@ManfredBartz]

Interesting, thanks. 🙂 Regarding K2, what about bone health? Can K2 reverse ganglia caused by osteoarthritis and bone-spurs on the distal interphalangeal joints? Can it improve bone density? Are co-factors necessary, such as magnesium? Regarding CVD, there is a retrospective study with >1000 participants which shows significant benefits from high dose nattokinase supplementation and additional benefits when combined with K2. doi: 10.3389/fcvm.2022.964977. Any thoughts on that?

[@tracysmith245]

depends on need to exercise if you are overweight can not get vitamin d regulates the calcium to your bones I try to eat and drink whole foods it has worked for me i have low calcium though things like spinach and kale are high in calcium coffee processed junk food dairy like milk cheese pull calcium from our bones

[@tonyc2489]

I have taken D3 and K2 for a couple of years and no longer wake up with painful swellings and distorted finger joints. The two joints affected have not subsided completely, but are no longer painful and no others have appeared.

[@luckssj]

K2-MK7 is not to be used alone. It comes with Nattokinase and add D3, Omega 3, and Nitric Oxide.

[@ÁzsiábaSzakadtam]

What is your take on people on warfarin? I'm really confused about warfarin vs vitamin K

[@betterplacetobe7896]

My calcium score was 100 so I took 500mcg of K2 plus 10mg Lipitor, after one year my calcium score was 0

[@veasnaphai8]

If you take Amlodipine, can you also take K2 ?. Any answer ?

[@VeggoFix]

According to some sources there is a risk of calcification of the arteries due to vitamin D consumption/fortification that could be lowered by also adding vitamin K2 As far as we have been able to look into it the evidence is inconsistent. What is your opinion on the supposed effect of vitamin D + K on the arteries?

[@emanuelgy729]

Nice one, interesting 😊

[@necrotic4816]

I'm gonna stick to exercise.

[@Lophophorawilliamsii]

A question if he would be so kind as to answer. Is there a natural treatment for autoimmune hemolytic anemia? I have that disease. I take a daily vitamin D3+K2 supplement. A digestive probiotic of various strains and once a week a vitamin B12 capsule.

[@azdhan]

Really interesting. Many thanks for sharing Dr Carvalho. As you have a good reporie with Dr Brewer that I also have a great deal of respect and admiration for as I do for you,,I would love to have you host Dr Brewer to have him highlight or speak to some interesting and compelling points he made on his KZbin channel video titled “The Widow Maker, Are You Off The Hook”. I am not trying to instigate issues, but I think that video highlights some interesting differences between how you both approach the issue of heart disease progression. Again, such a joint discussion would be useful/helpful to subscribers of both channels. This would be as interesting and helpful as the video you did where you hosted an open discussion with cardiologist, Phillip Ovadia. Thanks again.

[@mucus977]

K2 D3 and magnesium I call it the 3 amigo that works together

[@SandysDIYHealthAdvocacy]

Can you please doscuss K2 and bone density?

[@Tony-di5lp]

Thank you for bring us all the great information Gil. I've got a increasingly painful situation. I get horrible Cramps in almost every muscle in my body. I'm taking potassium, maganisium , drinking lots of water. If I yawn , I get cramps in myjaw. If I contract any muscle it will ball up in a painful cramp....any suggestions to stop this ?

[@timhanley4396]

Your videos are the best and thank you for the facts

[@Dondala]

You maybe right, if you just look at heart health. but we have to look at the hole human, to make a decision about supplementation. So, question is, e.g., is K2 needed, to get calcium to work where it belongs, e.g. in the bones? also, what is, if K2 is missing, and calcium therefore cannot be integrated in the bone? where is it then? Check this, and give an more complete answer.

[@Lennybird91]

If low risk and possible reward, it may be worth trying so far as it is convenient. There were concerns of mineral depositions and osteoporosis with my mother, so we incorporated K2 with her D and Calcium intake. Pretty difficult to gauge results, though.

[@NutritionMadeSimple]

this is why we like to go over the evidence, documented risks and benefits and let viewers make (their own) educated decision, the right choice may not be the same for 2 different people :)

[@Lennybird91]

@@NutritionMadeSimple Absolutely! I appreciate all your work, thank you.

[@themekfrommars]

@@NutritionMadeSimple It's worth taking for dental health alone. I have no plaque build up at all, ever, now I supplement daily with K2.

[@AnnieDog-arfarf1]

@@themekfrommars I just had a totally plaque-free hygienist visit. My first ever that I remember. I also take K2, D3, magnesium, zinc and a multi with mins.and a few others unrelated. I eat a low-carb (

[@LeonorCercena]

Coronary calcification takes several years to occur. The problem is that coronary calcification only assess the large coronary arteries and gives no information about the coronary microvasculature. It would be interesting to evaluate with a Sodium fluoride PET scan the global active myocardial calcification by using the Alavi-Carlsen Calcification Score, which is an earlier indicator of arterial calcification than the Agatston Score.

[@dvdmon]

Yeah, I mean obviously outcome data is key. In terms of logic when you look at this stuff, it seems like the proponents of K2 believe that it's helpful because they think that calcium deposits is what causes heart attacks. But what I believe I've heard on this channel and from other sources is that it is the soft plaque that is the most dangerous, not the hard, calcified plaque. And in fact the calcification itself "stabilizes" plaque and this could be one reason why you see calcium scores go up when taking a statin, that statins' risk reduction benefits are partially due to that plaque stabilization through calcification. So if you K2 supplements actually do work in the way they are supposed to by REDUCING calcium, does this actually do the opposite of a statin in that sense and prevent the calcification from happening and thus stabilizing that plaque? If so, that would seem to actually INCREASE the risk. But since none of the studies show an increased risk, then does that mean that they aren't really doing much to reduce the calcification in the first place?

[@Freddie1M]

did you get an answer to this?

[@dvdmon]

@@Freddie1M nope

[@skyseais]

Good observations and a good question. I wish we could get an answer.

[@narniadan]

Not calcified arteries but would like my arteries to be as pristine waters. What could I do to remove, clean probable plaque in my arteries without drugs.

[@nanna4486]

Solgar soya lecithin capsules

[@brendaoquin]

My endocrinologist suggested K2 for bone health as I have osteoporosis. What are your thoughts?

[@SewTubular]

Like other people have mentioned : D3 dissolves the plaque and K2 mk7 is the transporter to put the calcium in your teeth or bones. Without the D3 the K2 mk7 is less effective at getting the calcium to your teeth or bones.

[@chrishowe8614]

Fantastic! An American who can pronounce natto correctly! Thanks!

[@jeffagnoli9818]

What about calcium supplements? There are some studies that recommend whole milk to improve cholesterol

[@pumppump5428]

Maybe you firstly should have done the video about bone health and K2 and asked us if we wanted this one:) Thihi!

[@Mick-HHH]

Great video. Cant wait for a dr berg response

[@arciev.743]

Very informative My dr ordered I get a heart calcium score test and I came back at a 5, which now dr wants to put me on meds since she says I have beginning stages of heart disease. I will definitely view your other video. Thank you

[@jggrjk]

The whole Calcium in the body issue is confusing. I assume it isn’t all about how much Calcium is consumed but in how ones body deals with it in balance with Magnesium and vitamin D. I think I have read that calcium hydroxyapatite is the form of calcium found in the blood and bones, if so, are supplements with this ingredient harmful or helpful?

[@michaelmackey754]

I am a vegan of 11 years and the dentist says I have high calcium on my teeth every six months when I get my cleaning