SuperAgers and Metformin as Antiaging

[@hillbillybeerdranker6678]

my 91 yo Mother took Metformin for one year and her muscles got so weak she could not stand. I took her off of metformin and she is gaining her strength again.

[@laurensargent9471]

What about Berberine as an alternative to Metformin?

[@magdalenab6159]

Thats a great question, I am also interested

[@LuciaAronica]

Both berberine and metformin have been studied for their potential anti-aging and lifespan-extending effects, but there is limited evidence to suggest that one is definitively better than the other. While some animal studies have suggested that berberine may have comparable or even greater anti-aging and lifespan-extending effects than metformin, a randomized controlled trial published in the Journal of Clinical Endocrinology and Metabolism found that metformin was more effective than berberine in improving glucose control and reducing insulin resistance in patients with type 2 diabetes. This suggests, but does not prove, that metformin might also have greater anti-agin benefits for those with type-2 diabetes

[@robynhope219]

Maybe u could answer this: I am old and aging with chronic fatigue...could metformin reverse this? ​@@LuciaAronica

[@redberries8039]

16:40 I thought we needed more IGF-1 in later years to prevent sarcopenia. Clearly I'm worng wince he said the opposite, but he was not clear about the reasoning saying somthing about 'background'. Need more on that from someone.

[@redberries8039]

'we get better repairs' with lower IGF-1? That really needs more explanation.

[@robynhope219]

​@@redberries8039yes, his Age Later said.

[@liviacalvino6775]

Complimenti !

[@robynhope219]

I am old and aging w chronic fatigue...can metformin reverse this?

[@emilatarantino3263]

Buonasera Lucia Grazie per quello che fai Peccato che non sono in grado di seguire Ignorante in inglese Auguri per il tuo lavoro

[@LuciaAronica]

Scusa Emila. Ci provero'! A marzo registro 2 video in italiano. Stay tuned ;)

[@emilatarantino3263]

@@LuciaAronica grazie Lucia Io ci sarò ad ascoltarti Abbiamo bisogno di chi ci insegna a stare bene A essere noi medici di noi stessi, visita la sanità che cade a pezzi Di nuovo grazie e auguri per la tua ricerca

[@gianlucastrada548]

can we use bernerin instead of Metformin?

[@robynhope219]

Not as effective

[@SandrinaN]

Another consideration I have is at what age would one begin using metformin as an anti aging molecule? If higher IGF and high cholesterol’ are good for younger people but not older,. He also stated that it’s better to start anti aging processes before aging rather that after aging so it makes me wonder when is the appropriate time to start.

[@LuciaAronica]

There are many roads leading to aging. As of today it is unclear whether the potential anti-aging effects of metformin may be limited to those with a metabolic "ageotype" ( nutrient desensitization/insulin resistance)

[@Zoehandle]

Grazie x i tuoi video sempre stimolanti e interessanti. Come si misurano i risultati e i progressi ? ci sono degli esami specifici? Meglio cicli di utilizzo o si va in continuo come fa Sinclair? Buon lavoro!

[@violetka1197]

Sinclair e vegano..no carnivoro....

[@Zoehandle]

@@violetka1197 ho fatto altre domande

[@violetka1197]

@@Zoehandle non si capisce nulla..sinclaire sostiene che per rimanere giovanni si deve usare la dieta vegana....i carnivori dicono no ..per mantenersi giovanni si deve usare la dieta carnivora....NON SAPIAMO...chi e meglio..

[@Zoehandle]

@@violetka1197 ripeto che le mie domande vertono sulle assunzioni di certi farmaci e integratori. Cosa c'entra l'alimentazione?

[@violetka1197]

@@Zoehandle e il ripeto la mia domanda..🤣🤣🤣

[@robertstancliffsr9575]

Metformin 2000mgs daily for more than 40 years for type 2 diabetes. I''m now 81 and maybe the metformin is helping with my longevity? It's difficult to know for sure but I do not intend to stop taking it.......The longest lived of my close relatives died in their mid- seventies..........

[@gianlucastrada548]

bat have Metformin collateral effects?

[@robertstancliffsr9575]

All drugs have side effects so yes, Metformin does...... On me they are minor, and I am taking metformin, 2000mgs daily since I was about 35 years old. I am 81 now and in good health and still taking metformin......I have noticed on the internet that metformin is blamed for almost everything bad.........Works great for me.......I also do 2 sets of pushups daily with 20 to 30 each time. .....

[@chiaraconsolaro7038]

Bisognerebbe che almeno ci fossero i sottotitoli in italiano 😓

[@SandrinaN]

I would like to know more about inhibited muscle growth if on metformin. I see this as a problem. I don’t understand his explanation of it. It would seem to me a big negative to not get muscle growth especially as I age I am trying to hold onto muscle and strength.

[@LuciaAronica]

Metformin works by activating the AMP-activated protein kinase (AMPK) signaling pathway, which can have both positive and negative effects on muscle growth. On the one hand, AMPK activation can stimulate the production of new mitochondria, which can enhance muscle endurance and improve exercise performance. On the other hand, AMPK activation can inhibit the activity of the mammalian target of rapamycin (mTOR) signaling pathway, which is essential for muscle protein synthesis and growth. Several studies have suggested that metformin may inhibit muscle growth and reduce muscle mass in certain populations, such as older adults or people with diabetes. However, other studies have shown no significant negative effect on muscle growth or function. The potential negative effects of metformin on muscle growth may depend on the dose and duration of treatment, as well as other factors such as exercise habits and diet. Some studies have suggested that combining metformin with exercise or resistance training may help to counteract any negative effects on muscle growth.

[@SandrinaN]

@@LuciaAronica Thank you for that explanation.

[@violetka1197]

@@LuciaAronica you use Metformin o berberine..??

[@hillbillybeerdranker6678]

My 91 yo Mother took Metformin for one year and it made her muscles so weak she could not walk. I took her off Metformin and now she is building her strength back.

[@bobcocampo]

What is your opinion on using low dose Rapamycin to speed up autophagy? Exercise to speed up autophagy? SGLT2 Inhibitors? etc?

[@LuciaAronica]

Hi Bobby, we do not know the answers to these questions. We know that exercise stimulates autophagy. We actually know that autophagy is essential to trigger the positive adaptations to exercise. Overall, the best exercises for autophagy may be those that combine high-intensity exercise with endurance and resistance training. Additionally, incorporating intermittent fasting or time-restricted feeding into an exercise routine may also enhance the autophagy-promoting effects of exercise. However, the optimal exercise regimen for promoting autophagy may vary depending on individual factors such as age, health status, and fitness level.

[@bobcocampo]

@@LuciaAronica Thanks. Please have more discussion and research on Autophagy

[@alessandroalessandro1698]

Dottoressa..nulla per noi italiani? 🙏

[@LuciaAronica]

Scusa Alessandro. Ci provero'! A marzo registro 2 video in italiano. Stay tuned ;)

[@alessandroalessandro1698]

@@LuciaAronica 😘