T cell Activation and differentiation (FL-Immuno/31)

This video lecture explains the two signal hypothesis of T cell activation.

[@harryevers3424]

This was brilliant. I was using the Kuby Immunology text book which I felt was just over complicating the whole process and was very unclear as to what the two signals were. This video fixed all that in 5 minutes and was short and sweet!

[@FrankLectures]

Glad to know this. Thank you for your feedback.

[@stutikhadka6044]

I am using the same book, The book really leaves you confused if you actually understood or not, this video made things clear

[@Ahri_k_da]

@@FrankLectures same kuby just made me so confused. I have my exam in 20 mins, now i am watching this😅

[@Burglecutter]

You want the Janeway textbook.

[@madhavivyas9373]

Same I am too was referring Kirby and Abbas book but was so confusing and boring :)

[@faialnashmi4710]

This is more than great. Brief, informative, and crystal clear! Thank you :)

[@iangte6053]

Whoever made this videos. Thank you . You are amazing.

[@jelenatj1825]

This 5 min lecture was more helpful than 3 hrs lecture with my professor lol

[@FrankLectures]

Thanks

[@Kam16665]

Crystal clear. Thank you.

[@thebeets6055]

Best videos ever!

[@dariav.9275]

Thank you a lot for your videos, I never knew immunology could be so simple

[@FrankLectures]

Glad to know this. Thank you for your feedback.

[@mosesmuhane]

Lol immunology isn’t really “SO SIMPLE”😅

[@shahedhamdan4002]

That is amazing video!

[@redwanrimon6931]

Thank you for the crystal clear concept

[@brandymutiso4795]

Exactly what I needed 😊

[@hohnjopkins5705]

What software are you using to time the slide builds out with the voice over? It would really help me thank you for the videos they are awesome

[@eja9403]

This video is really helpful, the explanation was very clear.. I Love it! 😍

[@FrankLectures]

Thanks

[@martinkullberg6718]

It looks like 2 acces keys to activate a deffense weapon. Is it also possible they activate per exident (by mistaken indentity (in a pathogen)/or chemicals?

[@sadanandadas2162]

Very good 👍 appreciate ur lectures 👌

[@fweetnm3934]

Thank you very much it reallly helped mee

[@camillam.2364]

i think the activation of CD8 t-cells most often require the help of a cd4 t-cell (which produces the IL-2 that reaches the CD8 t-cell and induces its proliferation)? its like: cd4 t-cell and cd8 t-cell are bound to antigens on one APC.. at least thats whats written in janeway immunobiology book: the CD4 T-cell stimulates the APC to increase co-stimulatory molecules like 4-1BBL and b7 and this co-stimulates at the same time the CD8 T-cell bound to the APC and leads to the activation.. and IL-2 leads to the proliferation.. or am I wrong and thats a different process?.. i am a bit confused :(

[@srilakshmikalidindi2461]

Your lectures are so precise and excellent! Thank you so much. I would have never understood this topic without your lecturers.

[@ramchandrasuthar2848]

Very nice analysis

[@fadelali330]

Helpful,Thank you.

[@michaelkhuvung981]

Does CD8+ require costimulation interaction of B7 and CD28 for proliferation and differentiation?

[@tanya4334]

Awsm explanation

[@emannagy6781]

That was really so much helpful thanks sooo much

[@FrankLectures]

Thank for your feedback

[@subramanyanchaithanya216]

Thankyou frank lectures

[@aishab9286]

thank you sooo much

[@karisihem4363]

Prooving depend origin antigens or class molecules HLA ???

[@wassmmd8521]

Thx

[@mustajabalam3794]

great........very conceptual.....plz upload polymorphism and linkage disequillibrium

[@FrankLectures]

Thank you for your feedback. Next lecture series will be on the subject Genetics. These topics suggested by you will be covered later.

[@sarahpurple6547]

thanks a lot

[@FrankLectures]

You're welcome.

[@toulinma6916]

do activated t-cells PERMANENTLY release Cytokines or just when an MHC binds to it

[@toulinma6916]

can someone answer this pls

[@glaucovitiello4195]

Hi, Toulin! Activated T cells are short-lived cells. After activation in the lymph node, these cells migrate to peripheral tissues where they will exert their functions. If it's a CD4 T cell, it will recognize their cognate antigen on antigen presenting cells via MHC-II and secrete cytokines (necessary for activate macrophages if it's a Th1 cell or to isotype switch if its a folicular T cell or a Th2 cell, for example). The antigen is a survival signal for these cells and on the absence of the antigen recognition they die, and just memory T cells remain, which will be activated rapidly upon a next contact to the same antigen, but do not secrete cytokines at resting. The deletion of activated cells after antigen removal is part of immune homeostasis and is necessary to prevent overactivation of the immune system. So, shortly answering your question, cytokine secretion is boosted upon antigen recognition, despite their start secrete basal levels of these cytokines after activation. After antigen clearance by effective immune response these cells die. Hope it helped! ;)

[@toulinma6916]

@@glaucovitiello4195 Thank you so much for answering. So you are basically saying that activated t cells secret basal levels of cytokines but if they bind to an antigen the cytokine production is induced and they start to secrete more?

[@abuammarali5521]

Just WOW

[@FrankLectures]

thank you.

[@ramchandrasuthar2848]

Nice lecture

[@FrankLectures]

+Ramchandra Suthar thanks

[@mustajabalam3794]

Thanks....plz also upoload videos on techiques used in immunology with detail and interpretations like electrophoresis and others

[@FrankLectures]

yes, next coming video lectures on immunology are on the techniques used in diagnostic immunology.

[@FrankLectures]

+Mustajab Alam It would be nice if you can write here the names of techniques in immunology for which you want me to upload videos. Thank you.

[@mustajabalam3794]

techniques are....ELISA and its interpreation RID and interpretations ,electrophoresis...tissue typing and flowcytometry....thanks

[@FrankLectures]

+Mustajab Alam thank you.

[@shubhamshinde9535]

👍

[@user-bw5xn7cc2t]

What is rol the cd3 in cell plese

[@FrankLectures]

The function of CD3 is the assembly of TCR complex and signal transduction.

[@sandakagunadasa2709]

👍👍

[@SusieQ123]

Im just a patient here... Im told I have no T cells! Can i make more somehow?

[@bryanportillo7444]

possibly a bone marrow transplant, but you need close to a 100% match in MHC proteins.

[@mustajabalam3794]

Great video ....what are ur reference books for immunology plz

[@FrankLectures]

Thank you. I refer multiple books and Internet resources for making these video lectures. My personal favorite book is.. Primer to Immune Response, Take W. Mak

[@mustajabalam3794]

Ok thanks ...what about Kuby and abul k abbas immunology book ..?

[@FrankLectures]

They are also good books. But this one is more simplified and easy to grasp.

[@rezansweety2107]

👍🏻

[@leelavattikuti8247]

After mature naive cd4 + t cell leave the thymus and enter secondary lymphoid organs to need activation (its own self antigen presenting cell ) or pathogen

[@gideoncheruiyot1642]

I think it's the b cell which produces memory cells not t cell

[@davide2711]

Damn robot voice

[@kashminirmohi9522]

Please upload b cell maturation and activation video

[@FrankLectures]

+kashmi nirmohi sure, I'll upload the videos soon

[@FrankLectures]

+kashmi nirmohi B cell activation and differentiation videos have been uploaded. Check them out and please share your valuable feedback with us. Thank you.