The Origin of Aspirin: From Willow Bark to the Pharmacy Shelf

[@PatKellyTeaches]

Let's hear it. What's your NSAID of choice and why?

[@RottenWarlock]

Ibuprofen cause it’s not wrecking my liver as much as naproxen 😅 keep up the great videos !!!

[@amebolt218]

Ketotolac, best alternative for patients with history of abuse of opioids, and for EVAs worth considering opioids, like fractures!

[@kazukisaudios2203]

Asprin, because it’s cheap and doesn’t cause me problems lol, always works better than nothing. I just use low-dose stuff and rarely take it to save my liver😅

[@Budago]

Nalgesin, because it's really good against my migraine

[@dntmesswithmeow]

ibuprofen is my best friend atp i find it the best for headaches ~~

[@scpatl4now]

I hope in the future you do a video on the evolution of treatments for HIV...as someone who was diagnosed 40 years ago, I have been through it from the start (even a couple of years before the start). I think it would be really helpful for people to see how far we have come in such a short time.

[@Red_Twizzler]

Or how far we haven’t come? We developed a “vac” for the “c” word in less than a year. They could have cured you decades ago. You should be furious

[@hedgehog3180]

The virus itself is also as interesting as it is horrifying.

[@PatKellyTeaches]

That exact topic has been on my list for years. Before I do, I want to interview folks like yourself who lived during the evolution of HIV meds and understand what it was like first hand. If you're down for something like that, email me!

[@scpatl4now]

@@PatKellyTeaches I would be happy to.

[@apocalypse487]

We have so many options now. I just wish they were cheaper for patients. Canenuva is something we started using for longer than a year now. It's the most patient compliant medication, I think.

[@justinminer1354]

"They thought about making aspirin, but went with heroin instead." 😂

[@PatKellyTeaches]

To be fair, they **did** eventually get back around to aspirin

[@legitusername-zl7to]

it's like the perfect kid the parents cared about more ended up in jail while the kid no one cares about ended up being famous worldwide

[@BillAnt]

@@PatKellyTeaches - Aspirin doesn't do jack sh*t for me. After a tooth extraction I need heroin to take that pain away. haha jk

[@panatypical]

​If you need heroin for something like a tooth extraction, you have psychological issues along with the dental ones. I hope you don't end up on a slab because of it.​@@BillAnt

[@MKdross]

I mean, heroin is a much more efficient and powerful pain killer. If isn't until you regularly use it that issues arise with physical dependency

[@TheDeathopper]

As a medical student, I love your videos on pharmaceutical history and all your videos on medical history in general! It's so fascinating to see the evolution through time of now routine prescribing guidelines. How we got to where we currently are. The historical context really helps to bring to life the often rather dry medical information and highlights the monumental efforts undertaken to bring these "mundane" medications to market. I really appreciate all the work and effort that goes into your videos and I would love a follow up video on acetominophen. I would even suggest a similar series on the history of psychiatric medications, but I feel like you already have a laundry list of video topics already!

[@PatKellyTeaches]

Thanks for such a thoughtful comment! Of those two, acetaminophen will be the easiest topic to cover, but even that one is super extensive! Like in America, acetaminophen seems like it's in everything!

[@stuffinsthegreat]

@@PatKellyTeaches as an aside, I have a friend who was once prescribed co-codamol (paracetamol + codeine) at A&E and it blew my mind that that even existed

[@starbuck1776]

As a pharmacist, I really like, no love, your historical analysis of these most important drugs!

[@PatKellyTeaches]

Thank you! There are a bunch of pharmacists and pharmacy students in this community. Love to see it!

[@rebelliousraven]

I'm a nurse and ditto for me. Plus, if we ever have to start getting by naturally again - we know where to start. I'm glad I have pharmacist friends, though. 😂

[@ivacheung792]

YES-please, please, please make a video about COX2 inhibitors and FDA black box warnings!

[@hedgehog3180]

I synthesized aspirin in high school, ironically that same week I had to get one of my wisdom teeth removed.

[@lexinexi-hj7zo]

You should have synthesized heroin. That hurt so bad the doc gave me oxycodone as hydrocodone ACAP wasn't touching the pain.

[@BillAnt]

Aspirin doesn't do jack sh*t for me. After a tooth extraction I need heroin to take that pain away. haha jk

[@wnthrr]

I had synthesise aspirin in one of my pharmacy lab! I love learning how past generations discover things that we currently know and probably took for granted. Would love to learn about COX2 since i had done some research about it before while doing my assignment about aspirin but you made it much easier to understand :D

[@PatKellyTeaches]

It's always interesting to hear how revolutionary moments in science history, like synthesis of ASA, are routine in pharmacy labs now. Thanks for the feedback!

[@wnthrr]

@PatKellyTeaches it does help me to appreciate the works of previous scientists and researchers. And seeing how the crystals form irl is very interesting!

[@SnailShoes]

COX2, oddly I'm Rx'd one the old school COX2 inhibitors atm. You really don't hear much of them these days.

[@alancarnell2747]

I had to for Freshman Chemistry. Mine was so pure the professor folded up the filter paper and told me the next time I got a headache, use this. He said he hadn't seen any that pure for years.

[@alejandramoreno6625]

Me too, it was fun

[@Nmethyltransferase]

Did you know...? If someone's being treated with lithium, it's unsafe to take NSAIDs with it. The three exceptions are aspirin, non-acetylated salicylates, and sulindac. Acetaminophen, the other fever-reducing pain-reducer is also safe in combination with lithium.

[@PatKellyTeaches]

I did not know that, thank you for the fun[?] fact. Well, it's the kind of fact that I think is fun

[@SpoodyFlopp]

What mechanism makes it unsafe?

[@georgejanzen774]

@@PatKellyTeaches Morbid curiosity is healthy in a med professional

[@Nmethyltransferase]

@@SpoodyFlopp - They raise the blood levels of lithium. You take the prescribed dose--that your prescribing doctor believes produces certain blood levels, based on past labs. But in actual fact, you're getting overdosed. The precise mechanism is: COX inhibition --> alterations in prostaglandins --> reduced excretion of lithium --> increased blood levels of lithium If you need more detail, I dunno, go to medical school.

[@AD_AP_T]

@@SpoodyFlopp not sure about the details, but lithium has an extremely narrow therapeutic window; NSAIDs affect GI and kidney function, and slow down lithium elimination from the blood; "normal" NSAID use is enough to risk increasing the levels of lithium in the blood to toxic levels.

[@MrSaqeq1]

The fact that Aspirin comes from Salicylic Acid, the thing I put on my pimples, is hilarious. Also makes sense considering SA has anti-inflammatory properties when applied topically as well 😂

[@transkryption]

It's Salicylic acid's keralytic properties ie skin removing properties you're chasing in this context. Same with Salicylic acid, coal tar and sukphur forumulations.... (remove the other layers of flakey skin to treat the immature cells underneath)

[@AnotherPointOfView944]

Take Lymecycline. A long term antibiotic for acne. You will need a prescription. It works after 10 days of proper use.

[@scpatl4now]

I take 81mg of Aspirin every day as a preventative (Dr prescribed...fyi), and it's interesting to know all the history that brought it to this point in time

[@Abby_Liu]

interesting how that's half the dosage in one of the studies!

[@daviddelgado6090]

It's not all that often that such a comprehensive video is freely available. Thank you

[@PatKellyTeaches]

I appreciate that!

[@InfiniteLoop]

I had a heart attack June 6th, when I got to the hospital I was in pain, all over my chest, and arms, they pumped me full of aspirin and the pain was gone, had a triple a few days later, feel great now,

[@PatKellyTeaches]

Sounds like they were right in line with those AHA recommendations

[@PatKellyTeaches]

Also, I'm very glad you're around to tell the tale!

[@BrianMechling]

Well, they most likely gave you a few 81mg Aspirin, but they also most likely gave you nitro to quickly dilate your vessels as well as giving you morphine and Oxygen. While aspirin is effective in thinning the blood and preventing clotting off a major vessel, the Morphine, Nitro, and Oxygen were most likely the rescue meds that rapidly reduced your pain in this scenario…

[@bdr9519]

As a pharmacy student I love your videos, keep going

[@davidbringle379]

Nifty. I used to work in the pet industry. I became quite fascinated about medicinals developed for animal use migrated to human use. Absorbine Jr. started as a horse liniment. Small product in a smaller bottle sold at higher price per once.

[@No-mq5lw]

10:57 Darn shame that this ad's "DOES NOT AFFECT THE HEART" didn't get an editing effect alongside it to foreshadow it's relationship with blood.

[@PatKellyTeaches]

You're right! Missed opportunity!

[@Fomites]

Patrick, your videos keep getting better and better!

[@PatKellyTeaches]

Thank you! I'm having so much fun making them

[@Coccinelf]

Someone please tell me in what year they stopped selling Aspirin in metal tins. Because I'm only 42 and I swear I remember them from my childhood!

[@kredwol2103]

I take an aspirin every day (325 mg) to maintain insensitivity to NSAIDS, which has mostly cured my AERD (asthma) which I suffered from for 10 years. I suspect the desensitization process stimulates your cells into making ample COX-1 so that all breakdown of arachidonic acid doesn't occur via COX-2 pathway which leads to inflammation.

[@MarianneKat]

Do you also have the nasal polyps? I believe those 3 symptoms are commonly found together

[@kredwol2103]

@@MarianneKat Yes, and anosmia. They aren't as bad as they used to be. Never had surgery to remove them. Prednisone will shrink them temporarily.

[@jerryfraley5904]

First time encountering your channel, and haven't looked at your video inventory yet--but I think a history of migraine medications and how much research has changed the specific diagnosis of types of migraines and the different modern pharmaceuticals that have exploded onto the market in the past 20-30 years. Great content and presentation, keep up the good work!

[@davidponseigo8811]

I can honestly say aspirin has saved my life !

[@dntmesswithmeow]

was just about to sleep but this is way better! been waiting for this vid to drop 🙏🏻

[@PatKellyTeaches]

Let's go! Happy Saturday morning

[@adamchurvis1]

God, I remember when my mother gave me little orange-flavored "baby aspirins" out of this exact little tin! Right around 1965. Wow, what memories.

[@DamnMandi]

I’d love to hear you talk about metamizole/dipyrone. I find it quite interesting that a drug that is available OTC and sometimes even preferred over aspirin in Latin America/Asia, is banned in Europe and in Canada/USA.

[@agargamer6759]

Love learning about the history of medications we take for granted today!

[@markyoung01maccom]

I’ve just discovered your channel and loving it… great work !

[@garryferrington811]

My father (a Depression child) would buy aspirin on sale, then pour it into a big jar full of aspirin, on the bottom. The aspirin on top probably dated back to the second World War, old, old, old. I didn't know aspirin actually worked until I was in my twenties!

[@jwmeadow1]

Yes!!! Do a video on COX inhibitors! I work in health care, and love these videos.

[@timbehrens9678]

Hi Patrick, can you make a video about the Lime disease vaccine that was introduced and then removed from market?

[@PatKellyTeaches]

Lyme disease is on the list!

[@scout8145]

As a skin care nerd, I’d be very interested in a branched-off video about the history of salicylic acid!

[@pvtbuddie]

Thanks!

[@PatKellyTeaches]

Thank YOU! Glad you enjoyed the vid

[@caitlinelizabeth7808]

Love your videos!!! Thank you for all of the hard work you put in to these🙌🏼

[@PatKellyTeaches]

Glad you like them! The next one, insulin, is proving itself to be a beast of a research project

[@caitlinelizabeth7808]

@@PatKellyTeaches oooh I’m excited! Part 2 of insulin series could include insulin use in health care homicides- there’s definitely enough related information out there for an entire video

[@venessamaxwell8105]

And for me, epinephrine with all NSAIDS BTW-I listen to many medical videos, i'm so glad this one popped up because your voice and format are super easy to listen to.

[@nishitdronographer718]

Love the way he explains with so much in-depth research with such simplicity ❤🎉

[@simhthmss]

I would be interested to hear about the history of heroin going right back to how it was created at Bayer and why they thought it would be a non addictive treatment for morphine addiction. It doesn't seem logical to us today that addictive thing + acetyl group = non addictive replacement but, I get that they were working with much less information than we are now.

[@nolbertopatricioriveraraas4262]

4:48 I'll repeat a joke I made on your post about Mr. Eichengrün's moustache: everyone be aspirin' to a moustache like that!

[@hueyiroquois3839]

1:14 Modern tonic water contains no quinine.

[@DB78888]

Wake up babe Patrick just dropped

[@ryane53]

Literally this drop made my day. And I legit just graduated with my masters degree lol

[@CatMom-uw9jl]

@@ryane53Congratulations!

[@PatKellyTeaches]

@@ryane53 that’s wonderful! Congratulations! 🎊🎈🎉🍾

[@ryane53]

@@PatKellyTeaches Thank you!!

[@Pr3stag3]

Please reboot your bot and command it to reply with something original.

[@phinhnanthasone1231]

As I'm allergic to aspirin, I use paracetamol or ibuprofen if more in pain

[@MarianneKat]

Common allergy, but be ready to tell paramedics and ER folks your reaction cuz minor allergy means can still administer for heart attack and you will do better if you can tolerate it.

[@verdatum]

I was a pharmacy tech when the cox-2 inhibitors were getting pulled. It was wild, up until that point we were dispensing TONS of it, only to learn that it was deemed ungood.

[@Mark1JT]

I'm allergic to NSAID's and hence cannot take them, it sucks as all it leavesfor pain management is Tylenol/generic or opiates.

[@lucasgondim9833]

I'm always amazed by the quality of your content

[@keithcarpenter5254]

Viox was a fantastic anti inflamatory. Worked quick, no noticed side effects. Shame they didn't work on it.

[@raestone1760]

Did that one Aspirin advertisement mention preventing pregnancy?! I want to hear that history!

[@mhunt7843]

Great job. Detailed yet easy to follow. You present yourself well!

[@richardsmith4187]

Great story on how aspirin was developed !! Your a natural at explaining stories and I like that and have now subscribed !! Thanks for your interesting content

[@wapartist]

Is amazing to me scientists were creating useful chemistry at this time period

[@ameliamos]

i love your vids! your the only channel ive really found that has the perfect mix of educational and entertainment on history of medicine

[@Bobbyslides]

Will you comment on the overprescribing of aspirin and polio correlation?

[@lourias]

Did you know that allegic reactions cause the blood vessels to leak their fliuds? When the fluids leak out, the blood gets thicker. When the blood gets thicker, it can cause headaches and migraines. When this happensto me, I take an a 350 mg tablet if aspirin, and can get on with my life. Sonetimes, when the allergic reaction is severe, i will take 2 tablets. It reminds me of the old Alkaseltzer commercial jingle: Plop, plop, fizz, fizz, OH WHAT A RELIEF IT IS!

[@mistervacation23]

Not to mention that Bayer used to market over the counter Herion

[@Chimbleton]

Love this channel! Keep up the good work

[@skijazanowar]

@PatKellyTeaches the videos are really good and it'll be better if you use background music on it just like the physics/math video maker uses for eg Varitasium or Vsauce.

[@geosultan4]

The Celebrex video would be super interesting to me. I remember all the ads for it as a kid, then they all suddenly stopped. I’d be interested in understanding what Celebrex was, why it got so popular, and how it got pulled.

[@TgWags69]

I have a wierd metabolism for some drugs. Most NSAIDS do not do a thing for me. Aspirin was the only thing that gave me relief from chronic back pain due to several injuries and surgery. A few years ago, doc put me on Diclofenac for gout. I ended up developing an anaphylactic allergic response to it that sent me to the hospital with subsequent cardiac tachycardia and other issues from the adrenaline they used in the ER. Now I notice getting itchy when taking aspirin similar to what preceded the Diclofenac episode, so I'm afraid to take it. I've been curious if maybe switching back to a more natural form like the willow bark might still work without the allergy component. I'm not asking your advice, but if any commenters out there have made the switch, let me know how it works for you. Anyway, thanks for the video, it was very interesting.

[@deusex84]

Amazing video! You deserve more views.

[@EmilyJelassi]

I can't take aspirin... it gives me a horrible stomach ache. But I'm also not allowed to take NSAIDS either after my duodenal ulcer surgery in 2019. I REALLY miss ibuprofen and other anti-inflammatories.

[@milliedragon4418]

Hi, I am new to your channel and I am a new subscriber. I find medical history very interesting, I've been learning a lot about the dark history of it. I recently watched one of your previous videos about drug patents. However, there was one thing I learned that has always fascinated me, but I would love for you to do a future video on the tutor medical gardens even if it is far in the future. I find it fascinating that they had essentially a form of universal health care, albeit primitive before it was even a thing in the 20th century. I am saddened by the fact that in the USA our healthcare is so expensive. And isn't universal.

[@PatKellyTeaches]

Welcome to the channel! Sometime in the future, I want to do a series on the history of the US healthcare system. But it's such a massive topic, I need to figure out a way to tell the story in smaller pieces

[@michaelf7093]

Wish they still made those little tin boxes.

[@igorsantos8873]

Very good content. I missed a citation of aspirin prescription for diabetics, but I realized that it is due to the effects you mentioned in the video.

[@argusfleibeit1165]

Could you do a video about dextromethorphan? I'm taking a new kind of anti-depressant that mixes Wellbutrin with dextromethorphan (a cough suppressant), and it works really well. They are both out of patent, but the new combination has a patent and is quite expensive.

[@riccardoz2953]

Really interesting and well documunted. Plus i could easily follow all your talk even if im not english tongue Born.

[@PatKellyTeaches]

Thank you! I've got captions available in a few different languages too, if that's helpful for your understanding

[@cyrilio]

Probably Ibuprofen, for side-effect reasons. But I agree that Aspirin is pretty awesome. Next medicine: perhaps Insulin and the different variant that have been developed since it was originally found and made in large quantities. EDIT: I had no idea you'd make a video about insulin until I saw the end of this video. Awesome!

[@InfiniteLoop]

I remember Bufferin aspirin, and how they claimed buffering made aspirin not hurt the tum.

[@kg-Whatthehelliseventhat]

What exactly is bufferin I see it here in Japan?😊

[@AD_AP_T]

@@kg-Whatthehelliseventhat originally, it was just aspirin combined with an antacid (magnesium aluminium hydroxide, as far as I know). Now it's a brand that still offers a similar aspirin product, but also various other over-the-counter pain medicines.

[@InfiniteLoop]

As I understand it is aspirin with some added coating that makes it less harsh.

[@margaretr5701]

Yes! What happened to Bufferin?! I'd forgotten about it, yet would take it at work for a headache, back in the 70's.

[@CK-vs5mh]

Very good info

[@DrBismuth]

I just stumbled on this channel and I love it! Have you done any videos about taxol / chemotherapy agents?

[@PatKellyTeaches]

I have a tentative plan to cover some cancer meds, but want to hire a cancer drug pharmacologist to fact check that script. There's so much terrible information out there, and I want my contribution to be 100% accurate

[@LarixusSnydes]

​@@PatKellyTeachesThat's really commendable. Thank you for taking this in consideration.

[@theogretz9318]

could you do a video about the isolation of testosterone?

[@PatKellyTeaches]

Yes! I did one back in 2019, but there were some factual errors in it, so I took it down. I'll do another one some day

[@hypercomms2001]

It would be interesting for you to do a video about Heroin … it’s early history….

[@PatKellyTeaches]

I'd love to do a comprehensive history of opiates someday. Morphine is one of the oldest drugs ever

[@Raina-q1r]

Great stuff man

[@PatKellyTeaches]

Thank you!

[@samanthab3292]

Shocking to hear DuPont in a positive light for something 😅

[@wgolyoko]

Would indeed love a story describing the process of retracting a drug from the market.

[@helenel4126]

I think you need to do a follow-up video about Reye’s Syndrome and the resulting medical recommendation, that children should not take aspirin for a fever.

[@crabmansteve6844]

When I was younger I thought about *taking* aspirin but I did herojn instead. For about a decade. 😂

[@omkarpatwardhan3070]

I have to ask here as I am confused, there is a drug named eterocoxib which is said to be an anti pain and inflammatory drug, and blocks cox2 as said in its name. Why does it cause horrible inflammation of my limbs and face if it take it? It does not go well in my body. The question why? Also In India Paracetemol comes as Crocin, Ibuprofen as Brufen and Its combination as Combiflam by Sanofi which was I think banned in the US? Also aspirin comes as disprin for dispersible aspirin and Ecosprin for the Cardiovascular use.

[@AD_AP_T]

It is possible to be hypersensitive or allergic to basically any medicine, even if it seems contradictory. For example, asthma is an inflammatory disease, yet it's relatively common for aspirin and NSAIDS to trigger asthma attacks. Some people's bodies just don't "like" some substances.

[@allangibson8494]

The Asprin dose for cardiac problems is way below the dose used for pain relief (and a low dose helps alleviate the stomach problems).

[@drppenev]

Please do an episode on corticosteroids! They are a true miracle drug used for everything: renal impatient, transplantology to COVID-19, asthma, and so on.

[@chemistrycapital]

Another great video!

[@PatKellyTeaches]

Glad you enjoyed it! Insulin coming up next

[@taylortimbrook2030]

Your videos are the best, thank you

[@RomanBekker2022]

YES-please, please, please make a video about COX2 inhibitors and FDA black box warnings!

[@room5245]

Damn nice niche bro, going to watch all of your stuff probably! tyvm

[@Drobert882-ix3zf]

Thanks for the history lesson it was quite interesting

[@13donstalos]

For tooth pain or joint inflammation, naproxen works best for me. But I still use acetaminophen for headaches.

[@bamasurp]

interesting. I'm alergic to COX 2 inhibitors

[@lucillelong6719]

Wait so aspirin can help with cardiovascular problems? I’ve read that NSAIDs can cause cardiovascular problems. Is aspirin unique in this case?

[@SpoodyFlopp]

It really depends on the cardiac problems. Since aspirin is a blood thinner, long term use can cause the heart to work harder to circulate blood, potentially causing blood vessels to become brittle over time. Generally, this is in combination with other adverse cardiovascular factors like tobacco use, alcohol consumption, high blood pressure, etc. It's also somewhat harsh for the liver to process, and regular consumption increases the likeliness of system-wide issues. It is mainly beneficial to cardiovascular function when a patient already has some type of impairment. When my brother-in-law had a stroke after years of heavy drinking and heroin/meth use, he had to take aspirin to decrease the potential for blood clotting, which could potentially trigger another stroke or heart attack. Generally, the benefits are only for people who already have certain complications. It doesn't help a healthy cardiovascular system.

[@kimkimjoni]

Is there an interesting story on why some locations use the word paracetamol instead of acetaminophen?

[@joegen280]

I take it daily for blood thinner

[@ButmunkieOG]

I've always been curious why here in Australia we buy paracetamol and ibuprofen instead of aspirin.

[@schinderiapraemeturus6239]

Is aspirin even available to you in Australia? If not I can imagine why...

[@ButmunkieOG]

@@schinderiapraemeturus6239 It is now yes, can't say I was aware of it much as a kid but I was surprised one day when it turned up as a generic brand with the other two at the supermarket.

[@margaretr5701]

@@schinderiapraemeturus6239 You CAN imagine why? Would you please share, why?

[@baileyellison642]

20:31 hey! I take that for my chronic pain!

[@stanleydog1454]

I may not have been first, but I am proud to contribute to the view count 😊

[@PatKellyTeaches]

And I'm happy to have you contribute! Hope you liked the vid!

[@mendyboio3917]

Well done, thank you!

[@AllenJones-w3p]

The technical term for aspirin is acetylsalycilic acid. What a tonguetwister!

[@siberx4]

One thing I've never understood is that nonselective COX inhibitors are sold over the counter with few restrictions, but all the selective COX-2 inhibitors have either been withdrawn or are prescription-only due to potential cardiovascular side effects. Don't all the nonselective inhibitors _also_ affect the same COX-2 enzymes, and would thus also have cardiovascular risks? Are the selective inhibitors actually somehow worse in some way, or do we just allow ASA and ibuprofen to continue to be sold due to historical legacy? Is there something about _also_ inhibiting COX-1 (and thus thromboxane) that counterbalances this effect? Edit: To answer your question in the comments, I use almost exclusively acetaminophen when I require pain relief (being careful to heed the dosage recommendations as I'm aware there's a threshold effect that staying below avoids liver issues). While I generally don't get stomach ulcers, the classic NSAIDs invariably cause _mouth_ ulcers in me even when taken at moderate does for reasonably short periods - I'm seemingly quite sensitive to this.

[@hedgehog3180]

The drug names you give are always a tiny bit confusing to me because they oftenhave different names in Danish. Like Paracetamol is Panodil and Ibuprofen is Ipren.

[@PatKellyTeaches]

Good feedback, thank you. I try to use the non-proprietary name first since those are more internationally accepted (paracetamol, ibuprofen). Then since I have a mostly American audience, I'll mention the brand name. But as I understand, Panodil and Ipren are trade names, not generic names, yes?

[@AD_AP_T]

Panodil is a brand name (I think that's handelsnavne in Dansk...?) for paracetamol. We have the same in English-speaking countries: for example, when I buy paracetamol, it might be called Panadol, Panamax, Febridol, Paramol, Herron Gold, or a few other things. If you look carefully at a Danish Panodil box, you should see it says "Paracetamol 500 mg" on it somewhere. The same applies to ibuprofen, sold as Ipren/Ibumentin/Ibuxen.

[@hedgehog3180]

@@AD_AP_T Yeah that's how I figured out, I just think that no one treats them as brand names here.

[@veefrain6232]

Oh yeah in sweden we have Alvedon/ as paracetamol. And people will ask for the brand name alvedon when they aant paracetamol. But there is ipren and iprensa, for ibuprofen. Its interesting to see people call it by the brand name

[@GuilhermeMirandaRaiol]

I would love a video about dipyrone and why it is banned in much of the world. I always read that's lobby by Tylenol, because paracetamol has the same effects that banned dipyrone. We use a lot here in Brazil and it appears that we don't have a opiod epidemic because of it (dipyrone use is inverse proportional to oxy)

[@ramitkundu9869]

Also any video on the enigmatic nature of prion diseases such as BSE would be much appreciated

[@nobillclinton]

fascinating

[@shable1436]

I've never had an experience where aspirin worked on my fevers or pain. Even as a child, only ibuprofen, but i do know that the aspirin is great for cardio issues, and that's why i take children aspirin, im over 50 so that's when you need to watch out for all those things, luckily i never had any type of affliction yet, but i have a feeling high blood pressure, diabetes, and other problems will soon catch up to me, i used to never go to the doctor, now i go twice a month, and blood work, and i guess i have to thank God for my health this long. Im sure aspirin has saved many lives, but i could never tell what it does or doesn't do. They should have tossed that heroin recipe in the fire though, i wonder what they would have thought about today's epidemic

[@gothafloxacin]

This is unrelated but i would love to hear you talk about how people were able to stabilize naturally found nitroglycerin to make modern day medications like atropine and nitroglycerin. From what i know they used either IV grade d10 fluids or something similar.

[@CAMacKenzie]

Bayer is a German name, and in German it's pronounced like the English word buyer, except that the r is guttural.

[@RockinRobbins13]

We stole it long enough to change the correct pronunciation! As almighty Americans, we claim the unrestricted right to mangle any language we choose. So you live in a silly-named city of Munchen (sorry, American keyboard here! I can't even spell it correctly). So your name MUST be changed. From now on you live in Munich. Thank us! Deutchland? That's ridiculous. Now, you're GERMANY. Yes, I know it's more complicated than that but we still exercise our almighty right to choose your name. Thank us! And naturally, it's nothing at all to do with who YOU are. It's all about us. We do this to EVERYBODY! Firenze-->Florence for instance. America! Reinventing the world by mangling languages. And we're darned good at it. Talk to the British about what we did with the names of different parts of the automobile.

[@CAMacKenzie]

@@RockinRobbins13Every language mangles others. Native American derived place names in the U.S. are often the result of having been mangled (or even slandered) first by another Native language, and then by French or Spanish, and then again by English. German is not called Deutsch in other languages, either. In Spanish it's aleman, In Italian it's tedesco, in Swedish it's tyska, In Cherokee it transliterates to advtsi, in Polish it's niemiecki, which originally meant something like "unintelligible." I mentioned Bayer because I'm familiar with German. He mangles other German words, too, and I imagine he does the same to other languages. We actually have logical reasons for most of our names for car parts. The trunk, for example, was originally a trunk--a big piece of luggage--which rode on a luggage rack and which was made to match the car. It could be removed from the car, but since people rarely did so, it became a permanent part of the car but kept the name. Why do THEY call it a boot, other than that they called the analogous part of a horse-drawn coach a boot, but why was THAT a boot?

[@GodIwishIknew]

Ever considered a video about fluoroquinolones? Both because of serious and weird side effects and because they were some of the first computer designed drugs.

[@captaintrips2980]

I can testify that those drugs have serious psychological effects on one's mind.

[@gothafloxacin]

Is hydroxycloroquine related to quinine? I know hydroxycloroquine can be used for lupus.

[@InnocentVodalia]

It definitely is! Like the next Pokémon evolution. 😅 I take it for Rheumatoid Arthritis.

[@PatKellyTeaches]

What's this? Your quinine is evolving!