Brain-Derived Neurotrophic Factor (BDNF) | Signaling & Mechanism

[@electric7309]

🎯 Key Takeaways for quick navigation: 02:05 🔄 *BDNF binds to TrkB receptors, leading to their dimerization and autophosphorylation, initiating signaling pathways for cell survival.* 03:28 🌐 *Three main signaling pathways activated by BDNF converge to promote cell survival, anti-apoptosis, growth, and neuroplastic changes.* 05:32 🔄 *Akt pathway involves phosphorylation cascades, promoting survival and neuroplastic changes, both gene expression-independent and gene expression-dependent.* 07:08 🌐 *Phospholipase C gamma pathway leads to calcium release, activating calmodulin kinase, initiating phosphorylation cascades for gene expression and promoting survival.* 11:29 🔄 *Ras-MAP kinase pathway, triggered by BDNF, involves kinases activating transcription factors, promoting gene expression for survival, growth, and neuroplasticity.* 13:21 🔄 *Long-lasting changes in cell growth and neuroplasticity require alterations in gene expression induced by BDNF signaling.* 14:59 🧠 *BDNF promotes neurogenesis (growth of new neurons), synaptogenesis (formation of new synapses), and strengthens synapses, contributing to neuroplasticity.* Made with HARPA AI

[@spkspk1416]

Watching from India 🇮🇳. Very well explained. Thank you so much!.

[@andreluizribeiro2146]

Thanks a lot. It really helped me to understand BDNF's function and its pathways. Regards from Brazil!

[@iv0447]

Would you please make a video on how BDNF signalling may be altered by exercise and some drugs and supplements (eg. l-theanine, SSRI's), as a possible antidepressant mechanism? This video explains well the role BDNF plays in improving neuronal connections. It seems reasonable that depression is a loss or down-regulation in certain signalling pathways and BDNF might be one mechanism to restore it. Thanks!

[@nikjosafatow4167]

Following

[@BuddhishMusic]

Surprisingly, a quick google search shows microdosing lsd increases BDNF

[@Answeriz42]

Brilliant, easy to follow explanation.

[@SubaSoundaryaSanthiAnandhan]

Thanks for the video! One question: How Ca2+ is released from ER?

[@elcidgaming]

Wait so BDNF is proven to actually GROW new neurons? for decades it was always taught to us that they are impossible to grow right? this is amazing. so Boxers who had so much trauma have hope now right?

[@buzznikk]

Yes

[@elcidgaming]

@@buzznikk Thats so cool

[@chloedelairi8055]

Hello, thank you for explaining the bdnf. I have to do a job on this one, is it possible to give me the references of your explanations and image ? From France

[@Sorajjang]

Thanx a million! very well explained!

[@CatalystUniversity]

You are welcome!

[@beatrizanjosdeoliveira7895]

Perfect! Thank you.

[@davidsweeney111]

Great explanation of this signalling pathway Kevin! TrkB is Tropomyosin receptor kinase B (a receptor tyrosine kinase as you explained) en.wikipedia.org/wiki/Tropomyosin_receptor_kinase_B

[@VanessaDayleRaeWaggoner]

Thank you

[@JamieCarter-n2n]

Jones Route

[@the2kcrew287]

It’s not pronounced A pop tosis 😑

[@kassemnizam1687]

U should add poo

[@HolmesMolly]

7755 Armando Place