Will Glycine Supplementation Reduce Homocysteine?

[@conqueragingordietrying123]

To figure out how much glycine to supplement with, I used cronometer to determine my average daily glycine intake that corresponded to each homocysteine test, and then investigated the corresponding regression equation. Although the correlation was just outside of statistical significance (r=-0.36, p=0.09), I can still use the corresponding regression as a rough estimate of how much daily glycine to take. That equation is: Homocysteine = -1.36 *average daily glycine intake +15.4 I then aimed for a homocysteine target of 7.5 umol/L, which is close to my levels in youth, and based on the regression equation, I'd need about 6g of glycine/d to get there (assuming that correlation = causation, of course). Based on cronometer's values, my daily average for glycine is ~4g/d, which means that I'd need to supplement with an extra 2g/day. We'll see how well this works (or not) with the next blood test, sometime in January!

[@paulelkins425]

I'm very interested to see your results! I started supplementing with glycine in Nov at about 3gr/day. I use 1.5gr in my coffee where it provides the added benefit of sweetener replacement. I also add about 1.5gr to my Steel Cut Oats/nuts/chia/hemp/berries breakfast. I started using it to hopefully boost my GSH levels and collagen levels. I'm hoping the increase in collagen will support bone health among other secondary benefits.

[@tommyortiz6623]

This is awesome you found a way to reduce homocysteine! I’m also going supplement with this starting today!

[@conqueragingordietrying123]

@@tommyortiz6623 Ah, *maybe found*. We'll see how it goes for the next test in a few weeks...

[@ResearcherJournalist]

@@conqueragingordietrying123 any updates on your test results with Glycine and Homocysteine?

[@conqueragingordietrying123]

@@ResearcherJournalist Yes, see this video (glycine-homocysteine data starts at 4min 05 sec): kzbin.info/www/bejne/rHy2f6umrbp1fJo

[@drytropics]

Trimethylglycine (betaine) is often recommended for lowering homocysteine. As the majority of SAM (SAMe) methyl donors are used to create creatine and phosphatidylcholine I take both these as part of my homocysteine-lowering regime. As you would know both have additional health benefits, with 5g of creatine daily seemingly a safe and effective dose. While often just B12 and folate are recommended the methylation cycle also depends on sufficient B6 and B2. I take an activated multi-B which contains methylated folate and B12. To lower my SAH, which builds up in conjunction with rising homocysteine, I take forskolin. SAM is converted into SAH after donating a methyl group, and then is converted into homocysteine in a reversible process (excess homocysteine can be converted back into SAH). There needs to be a balance between SAM and SAH for proper methylation to occur, with excess SAH supressing methylation. Raised SAH may be one reason lowering chronically high levels of blood homocysteine doesn't lead to better health outcomes. So far forskolin is the only supplement I've come across that seems to lower SAH levels. Taking SAMe unfortunately dies not fix the SAM/SAH inbalance as the SAM is converted into SAH. I have taken N-acetylcysteine for a while but recently upped my daily dosage to 5g and added 5g of glycine, as this combination has recently been shown to very effectively raise flagging glutathione levels. I've also recently added 200mg of hyaluronic acid and 10g of hydrolysed collagen peptides, as the science indicates both are effective in rebuilding collagen in the body. I'm not so worried about the outside wrinkles, but need to boost the collagen in my joints and arteries. In my case my raised blood homocysteine levels were genetically high and weren't detected until after it had initiated accelerated atherosclerosis, partly through boosting systemic inflammation and direct damage to the arterial endothelial layer. Homocysteine thiolactone also binds to proteins throughout the body rendering them dysfunctional, so I've tried to autophage away as much damaged cells as possible and now am trying to boost angiogenesis through rebuilding lean muscle. I've read the body can grow new arteries around blockages, but other than some injectable peptides I haven't come across any angiogenesis promoting supplements. Let me know if you can think of anything that could help grow new arteries. Now my blood homocysteine level is low any new arteries I grow should be free of the accelerated athrosclerosis. A Facebook page you may be interested in is Homocysteine Research, as its main aim is to share peer-reviewed scientific research papers relevant to homocysteine.

[@jonduringer5848]

Which injectable peptides have you heard supposedly benefit athero? Have you heard of any injectable peptides that exacerbate athero?

[@stefanweilhartner4415]

you could also eat enough protein. and try some betaine hcl + pepsin. and leave it at 1g NAC + 5g glycine

[@danguzman4676]

The Book "Bypassing on Bypass" shares how a form of Numatic Air Boots can aid in the New arterry offshute. I find my Numatic Boots 2 20 minute session right out of a Hot Shower is the Best relaxation Therapy anyone might avail them self.

[@dorteleiteritz5460]

@@60-Is-The-New-30 Solid advise, as creatine actually uses magnesium, so you need even more.

[@MsElaine122]

Re angiogensis; You might look into HBOT. Many local clinics are offering 1 hr sessions in 1.3ata soft HBOT for $70/hr (here in Atlanta). Buying one has become affordable. We are looking at a sitting style. There are 2-3 FB hbot groups.

[@lennydaiglejr3094]

At 59 I had a measurement of 14.5; I added methylated Folate and B-12. My number dropped to 7

[@conqueragingordietrying123]

That's great @lennydaiglejr3094! The homocysteine journey hasn't been as straightforward for me, still working out doses.

[@ZoomGadget]

@@conqueragingordietrying123 in his book Upgrade your brain, Patrick Holford says you have to take b6, b9, b12 AND omega 3 DHA/EPA and cholin to lower homoceistein. If just one of these nutritient is missing, you won't reduce homoceisteine.

[@lennydaiglejr3094]

@OpenlyBritish Exactly how long I don’t recall . My first blood test was in April of 2021 and the follow up in August; so it was fairly quickly

[@kamanashisroy]

Thanks! Best video. Everyone should know statistics.

[@conqueragingordietrying123]

Thanks Kamanashis Roy, and I agree! I'm not sure that I can get donations on KZbin-using this site definitely works, though: www.buymeacoffee.com/mlhnrca

[@lucioink_]

@@conqueragingordietrying123 could be copper overload, every time u sup with b6 u dump copper imparing methylation

[@DumbBirb]

You're one of my favorite "fight against aging" content creators, thanks for sharing with us your journey ! I'm glad that you decided to use Glycine, I've been supplementing it for a long time. It would be quite interesting to see a list of what supplement you use, and I don't mean only pills and powders but also foods. Like always making sure to eat a few nuts everyday. I've been going through your videos for a while but I think having a quick to read list in the video description would be really nice. Thank you !

[@conqueragingordietrying123]

Thanks John Rambo. I post my daily diet on Patreon, and a diet update video will be coming in the next couple of weeks, but here's the most recent video for that: kzbin.info/www/bejne/gXqUn3qkfJalbsU

[@Awsummm]

This is a 5* video , well explained and detailed, life saving!!!!……thank you

[@davidthompson8208]

Great video! I'm looking forward to getting more of my real data so I can begin to move the needle intentionally and be able to see what things move them in the right direction. Thanks for skating your life and journey and how you think about this goal: it is very illuminating... and motivating!

[@conqueragingordietrying123]

Thanks David!

[@JaguarPriest]

30 year old male. 23.2 HM....Ive had and still have tons of health issues. Doing a full panel of all vitamins and then im going to go at it.

[@weiminyang7206]

I'm looking forward to seeing your results.

[@conqueragingordietrying123]

Thanks Weimin Yang!

[@rwh4114]

I take 2 Magnesium Glycinate caps per day which provides approximately 2Gs of Glycine. So I get 2 supps I want in the same pill. 60 y.o. male with 9.2 of homocysteine on most recent blood test.

[@mmortal03]

I take the Doctor's Best product, for example. It's 2000 mg magnesium glycinate lysinate, of which 200 mg is elemental magnesium. Not sure how much of the remainder is glycine versus lysine.

[@rwh4114]

@@mmortal03 There is no lysine. It's formulated with Mg and Glycine, no lysine in it. Possibly a small amount of filler.

[@ollymounara605]

You could still be low in vitamin B6 and zinc if you've got pyroles disorder. It will distribute more of that out of the body.

[@randyalbertsw1992]

My homocysteine typically ran 12-18. With methyl B vitamins this dropped to 9. With 8 g glycine and 8,000 mg NAC it is now

[@conqueragingordietrying123]

I'm not sure that too low is a factor for homocysteine-as shown in the video, all-cause mortality risk increases starting at very low levels of homocysteine.

[@jackbuaer3828]

@@conqueragingordietrying123 Low homocysteine (hypohomocysteinemia) has been called out as a risk. I have seen it stated that individuals with low homocysteine (under 4.0) have limited capacity for response to oxidative stress and certain kinds of toxin exposure.

[@conqueragingordietrying123]

@@jackbuaer3828 Can you post that link, jack, as it disagrees with the ACM meta-analysis data.

[@jackbuaer3828]

@@conqueragingordietrying123 This is actually more concerning if accurate, since the numbers below do not represent low homocysteine. "Results During the follow-up period (mean = 5.4 years, SD = 0.9), dementia and AD developed in 85 and 64 participants, respectively. Not only the participants with high serum tHcy (≥10.6 μmol/L) but also those with low serum tHcy (≤8.9 μmol/L) were 4-5 times more likely to develop dementia and AD compared to those with serum tHcy levels between 9.0 and 10.5 μmol/L. With the increase in serum tHcy concentration, the use of vitamin supplements decreased, and 41.2% of the participants with low serum tHcy (≤8.9 μmol/L) were taking vitamin supplements. Conclusions Not only hyperhomocysteinemia but also hypohomocysteinemia considerably increased the risk of dementia and AD in older adults. The risk of dementia that results from overuse or misuse of vitamin supplements should be acknowledged and homocysteine-lowering health policies should be tailored to consider dementia risks that are associated with hypohomocysteinemia." Jong Bin Bae, Ji Won Han, Junghan Song, Kyunghoon Lee, Tae Hui Kim, Kyung Phil Kwak, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Seok Woo Moon, Joon Hyuk Park, Seung-Ho Ryu, Jong Chul Youn, Dong Young Lee, Dong Woo Lee, Seok Bum Lee, Jung Jae Lee, Jin Hyeong Jhoo, Ki Woong Kim, Hypohomocysteinemia may increases the risk of dementia and Alzheimer's disease: A nationwide population-based prospective cohort study, Clinical Nutrition, Volume 40, Issue 7, 2021,

[@jackbuaer3828]

@@conqueragingordietrying123 See Significance of Low Plasma Homocysteine Richard S. Lord, Ph.D. and Kara Fitzgerald, N.D. It does not appear to be a peer reviewed paper.

[@Always-xl9db]

I am taking L-Serine along with Glycine and NAC for glutathione synthesis, before bedtime.

[@conqueragingordietrying123]

Are you doing that to impact sleep? I don't notice a difference for my sleep quality or duration with more glycine.

[@alices4105]

@@conqueragingordietrying123 I had major problems with sleep. I fixed it for good by taking the following supplements before bedtime: Magnesium Glycinate, Magnesium L-Threonate, B1, NAC, L-Serine and that worked like a charm. I started to take extra Glycine on top of that just to make sure I have enough in the system readily available for NAC and, hence, glutathione synthesis…and no, it did not make me more sleepy, or improved sleep quality, I think magnesiums and L-Serine did all the heavy lifting, also NAC that decreases cortisol.

[@vipulgupta]

@@alices4105 Can you pls mention your dosages

[@pariodeusex]

serine may also be reducing Homocysteine uptake in addition to influencing the metabolism of it. Glycine was also shown to reduce Homocysteine in this study> "Inhibition of homocysteine-induced endoplasmic reticulum stress and endothelial cell damage by l-serine and glycine" PMID: 27064126

[@conqueragingordietrying123]

Yep, thanks for that!

[@reforesters]

Note that after I found out about the downsides of having high homocysteine from your site, i checked mine and it was in fact high - at 15.6. I subesequently started with "Homocysteine Resist" from Life Extension. Following the start of that routine my homocysteine quickly dropped to 9.x and has stayed there. A couple of thoughts about that move versus your idea to start Glycine. 1) Aside from a deficiency in Folate/ B12/ B6 causing high homocysteine, have you considered the opposite, that a surplus of those vitamins might have a drug-like impact lowing HCY more than simply maintaining adequate levels? Note that Life Extensions products provide far in excess of RDA - for example 41000% the RDA of b12 for example. 2) The LE product also has B2, but I didn't see you mention it. Possible that is another required vitamin for keeping HCY low?

[@conqueragingordietrying123]

Hey @Think Supersystemic, I'm happy to hear that you've reduced your homocysteine! While high doses of methyl-B12 may bring mine down, that's also significantly correlated with a lot of biomarkers going in the wrong direction. To your point yes, which is why I'm trying to go away from supraphysiological levels (i.e. B12), and towards other means for bringing homocysteine down. Glycine may be a better bet (for me), as I'm not deficient in any of the 3 vitamins mentioned in the video.

[@reforesters]

@@conqueragingordietrying123 Looking forward to your progress reports on glycine/HCY. Which biomarkers have you seen go in the wrong direction with too high on B12? I did stop homocysteine resist recently because of high b12 levels. Would be good know which other biomarkers I should check in on.

[@conqueragingordietrying123]

@@reforesters See 36:00 in this video for the B12 biomarker correlations (in my data, it may be different for you, though): kzbin.info/www/bejne/g6fIeHtqrbOqo7c

[@icebox_Intruder]

I'm 44 and had my HCY tested for the first time in February: 7.2, and I don't take any of the stuff you mentioned, but I do take enough stuff to fill gaps. HOWEVER, I recently realized my collagen supplement (which Ive taken pretty regularly for a few years) has 2.6g of glycine per serving. The caveat is that I only take half a serving per day and, probably doesn't play into it, but also only dose 4 or 5 days a week on average. Do you think thats a contributor (obviously, without knowing anything else I take)? I recently kinda started taking glyNAC (I've been taking NAC for about 18months) before bed (~400mg); I say "kinda" because its a magnesium glycinate, not pure glycine. So, "mag glyNAC." Is that similar?

[@shubhamvibhuti]

No

[@-Kerstin]

When the body makes its own creatine it produces homocysteine as a by-product. Have you looked into creatine supplementation to bring down homocysteine? This study might be interesting doi: 10.1111/fcp.12442.

[@conqueragingordietrying123]

Creatine is also on the short list, with glycine, for future homocysteine experiments. Thanks for the suggestion, Kerstin!

[@toomanymarys7355]

@@conqueragingordietrying123 Since you are almost vegetarian, you should know that homocysteine is ALWAYS high in vegans unless they supplement with creatine.

[@lindapestridge3073]

@@toomanymarys7355 I've been a vegetarian for 20yrs and i did'nt know that.

[@neilquinn]

Have you investigated using riboflavin/other B vitamins to reduce homocysteine for people with the MTHFR variant?

[@conqueragingordietrying123]

Nope, not yet

[@MeiinUK]

Try taking L-methyl folate to convert the expected molecules into an actual finished reaction process. There is a long discussion here on 12:38.... kzbin.info/www/bejne/p6exfYGibNR9pK8 I've experimented with Solar's "chelated magnesium" (bi-glycinate) before, and this helped me. So.. I also do wonder if I also have the MTHFR varient also. I know I have endo. I've bought a 23andMe kit, but have not done it yet, to see what issues I've got. Then I know which varient, and therefore the percentages that it is impacted or not etc. Now I get why these specific supplements exists in my local health food stores.

[@neilquinn]

@@MeiinUK Thanks will look into it. I have some b12 but not sure how much it matters.

[@MeiinUK]

@@neilquinn : It matters a lot. You will feel a lot better if you complete the chemical reaction that is supposed to happen in the body. When you don't... Diseases surfaces and the life span shortens etc. And for a woman... fertility doesn't happen basically. Some people say that eating certain food helps. Which is true. But in today's global food chain ? Can you always get those food at the drop of a hat ? No. So the supplements is a back up plan is how I see things.

[@neilquinn]

@@MeiinUK I'll look into it. I have the strongest MTHFR mutation.

[@jadeceazarfitness]

Wow your channel is full of gem's

[@conqueragingordietrying123]

Thanks @jadeceazarfitness, subscribe and click the bell notification!

[@jadeceazarfitness]

@@conqueragingordietrying123 already did 🔥

[@dirkh0]

If I don't forget, I take collagen. Glycin is a big part of it (22%). Do you think, pure glycine is much better?

[@conqueragingordietrying123]

I wouldn't say better, but I have a specific hypothesis that I'm testing, with glycine as the focus. Would taking collagen be better? Possibly, but I'm not sure

[@stefanweilhartner4415]

if your stomach acid and pepsin level is on point, then collagen gets broken down into the individual amino acids and you are fine.

[@adm129100]

Are you also considering NAC to go with Glycine ?

[@conqueragingordietrying123]

Nope-as mentioned in the video, if I'm able to reduce homocysteine with glycine, then I expect an increase in cysteine (NAC is used as a source of cysteine).

[@deanrobinson2459]

I wonder if you will/have noticed skin improvements with glycine.

[@conqueragingordietrying123]

It's only been about 2 weeks, so not yet...I do have dry skin in the winter, and so far, there's no improvement for that. I'd bet that humidity in the winter impacts dry skin more than glycine, though.

[@les0nick]

Did you have a chance to look at the recent studies on Glycine and N-Acetylcysteine (GlyNAC)?

[@conqueragingordietrying123]

There are videos for those papers on this channel...

[@les0nick]

Thanks. Found it!

[@philipblaauw6296]

Thanks for sharing this video with us! Could the cause of the link in all cause mortality and homocysteine not be lower glutathione levels or another mechanism whereby higher homocysteine levels are just a symptom and lowering homocysteine as such will not help...?

[@conqueragingordietrying123]

Yes, definitely! If serine and B6 are adequate, cysteine will be formed, which is a part of glutathione, and can be incorporated. Cysteine levels decline during aging, which highlights the importance of reducing homocysteine with adequate serine and B6.

[@larsnystrom6698]

Mortality increases with age. Homocysteine increases with age. ==> Mortality increases with Homocysteine. Causality? Is the mortality cased by age or by Homocysteine? Or both?

[@jefflittle8913]

Homocysteine is associated with stiff arteries and higher incidence of heart issues. Obviously some people live very long lives with a number of different heart issues, but they are the ones that beat the odds. As far as the age thing, vegans develop problems if they are short B-12 and meat eaters develop problems if they are short folate, for example from greens, and everybody has issues related to the AA pathway (sorry, I don't remember the details. The serine pathway above is a new one for me.

[@justsaying7065]

Great video. 2g of glycine is a very low dose. You may get more benefits (other than lowering homocysteine) from taking a higher dose. By the way, it would be great if you could do a vlog of grocery shopping - so we can see what foods you buy.

[@jackbuaer3828]

He has done several videos that show the foods he eats and their respective amounts. Hint: He could be called the Strawberry King. Mushroom King could also be another moniker. These names have more appeal (to me) than a name like Liver King. I am not sure that watching him push around a cart at a store would add much to our collective knowledge. I might watch such a video if he added some additional entertainment value. Perhaps he could develop a character (e.g. Mushroom King or Strawberry King)? I am guessing that the above suggestion would not go over too well in the Research and Academic communities.

[@conqueragingordietrying123]

Ha jack, I don't like the "Strawberry King or Mushroom King" names. Blood Testing King maybe better? Ha, as long as I break the human longevity record, that's most important.

[@conqueragingordietrying123]

Thanks @Just Saying. The key is to impact homocysteine without messing up anything else-with a higher dose, that may not be the case. In the pinned comment, I show why 2g may be sufficient.

[@justsaying7065]

I know what foods he eats. It’s fun to watch vlogs. You’ll be surprised how popular vlogs are. Also, it’s better for the channel to provide a variety of videos, rather than one format. It will help this channel grow.

[@jackbuaer3828]

@@justsaying7065 Okay, but if he shops, I think he should add some pizazz to the video. Perhaps if he had a troop of dancers following him while he shopped? I am not sure how we could work a longevity theme into that. I'll keep thinking about this.

[@stephanygates6491]

What happens to the cystathionine? Oh. When will I learn to wait to comment? Thank you! I just began specific glycine supplementation, beyond my magnesium glycinate, to complement N-acetyl-cysteine.

[@LaneCodeRedCarnivore]

Glysophate effects glycine , see Stephanie Senoff . Wheat and oats are highly sprayed at harvest to dry / desicate the plants.

[@LaneCodeRedCarnivore]

And if they used cereal that would effect results of the study.

[@MichaelAmen316]

L-Glycine vs Glycine (free form) - which do you recommend?

[@DavidPaulNewtonScott]

There is an underproduction of glycine to support collagen. My strategy is to consome collagen and top up with glycine to flush out the homocystine. That begs the question how much glycine? I suspect it may not be much.

[@tonyprophet3177]

Incredible content you create -- well done!! I'm confused with comments on TMG being a circularity to homocysteine but glycine is not -- can you please clarify?

[@conqueragingordietrying123]

Thanks Tony Prophet. As mentioned in the video, the key is to pull homocysteine downstream-when combined with serine and adequate B6, it will get out of the folate, B12, and TMG cycles, thereby allowing maximal reduction.

[@jenniferl8714]

That was really interesting. I’d like to know what diet you were on at the time. I’m wondering if a keto diet solves all the fundamental issues.

[@conqueragingordietrying123]

Hey @jenniferl8714, I'm not on a keto diet, but my diet isn't low fat, either-fat is ~40% of total calories. Full diet info is here: kzbin.info/www/bejne/a2LWhIirZbWUmLc

[@kevineakins5276]

Excellent video. You show so clearly the key pathways. I remember dr Jonathon Wright, ND recommending glycine for better sleep. Probably due to its beneficial effect on methylation and thus the transition into a state of sleep(?). At what low level of homocysteine does ACM begin to rise? Did you do an earlier video on homocysteine?

[@conqueragingordietrying123]

Thanks Kevin.Unfortunately, I haven't noticed an impact on sleep with glycine supplementation, but it's possible that 2g isn't enough to move the needle for that. For the ACM data, it looks like ~1-2 umol/L. Yep, if you search "homocysteine" on this channel, there are a few videos...

[@stellarblur]

Less methionine, which leads to less homocystiene which leads one to the inevitable (whole food, plant based,) and working physically everyday

[@brauliobo]

what is the follow up video after glycine supplementation? did it decrease homocysteine?

[@conqueragingordietrying123]

Unfortunately not. I'd suggest watching the biological age (PhenoAge) update videos, as I've been updating experiments for homocysteine (and other biomarkers) there...

[@brauliobo]

@@conqueragingordietrying123 thanks, will look for them!

[@sranney1]

Does niacin increase this

[@ShouldertoCrayon]

Absolutely

[@monnoo8221]

hi there, as always very impressive... question: you stick very much to the RDA... usually you try to get 2..4 times more than recommended. Well, the RDA for vit C is 70 mg, which is way too low, similar for vit D3, ... so here, given that B vitamins are very hard to get overdosed, a selective increase of B6 seems the only logical drain. Th rest of the metabolism is part of a big network, which is probably hard to move regarding its "set points" Which brings me to another point, s.o. else already mentioned. Physiology is about a logistical and informational network, simply increasing all good stuff way above RDA may not have an effect. It is about the state of the whole thingy, and a differential supplementation. That is, the individuality of a particular physiological system is better described by a profile, not by a collection of single items. Such profiles can be evaluated using machine learning. I did that already 16y ago in various medical contexts...

[@conqueragingordietrying123]

I don't stick to the RDA, I follow the correlations for diet with blood biomarkers. There is no hard-and-fast rule for how much above the RDA, it varies based on the correlations. For ex, in my case, 2.5x the RDA for niacin, but 18x the RDA (or AI) for Vitamin K.

[@chickenlittle829]

@@conqueragingordietrying123 hurray for measurement over RDAs!

[@newdata]

lowering methonine could also do the trick

[@kto-totam2876]

What to do if it homocysteine dropped to 3 after taking methylated form of b12? How to increase homocysteine because feel terrible and aged fast.

[@barasra8847]

Your blood test is really good, if you have added Lp(a) would be complete. Can i add this test in addition?

[@conqueragingordietrying123]

Hey Baras Ra, I've added Lp(a) to every test for the past few years, and track it in conjunction with diet.

[@barasra8847]

Hi sorry I don't see Lp(a) in home test kit(Siphonix). Am i looking in wrong place?

[@conqueragingordietrying123]

@@barasra8847 Lp(a) is not in the Siphox Health kit-in contrast, I add Lp(a) by venipunctiure to all my blood tests, that's what I though you meant. ApoB is included in their kit, which includes coming from Lp(a).

[@KJ-um1gq]

Was there a follow up on this, doc?

[@conqueragingordietrying123]

Hey K J, that data was in this video, starting at 4:05 kzbin.info/www/bejne/rHy2f6umrbp1fJo

[@KJ-um1gq]

Hi Doc. I found that one last night. Have you been able to identify a possible method to reduce homocysteine yet?

[@conqueragingordietrying123]

@@KJ-um1gq Besides B12, not yet. But the next hypothesis is that serine + B6 should work,-it's just a question of the right dosage to reduce homocysteine without messing up anything else. Currently on that regimen now, video coming probably next week with the mechanism.

[@KJ-um1gq]

Looks like the B6 + serine hypothesis failed as well, Dr. Have you found anything that’s worked? You know, methionine intake actually reduces homocystine. Unfortunately, methionine intake is correlated with a lot of negative things as well though.

[@rdance3]

Propionyl-CoA Carboxylase (Biotin) should also be considered.

[@conqueragingordietrying123]

is there published evidence that it reduces homocysteine?

[@rdance3]

@@conqueragingordietrying123 No, but I've read that reduced Propionyl-CoA Carboxylase avitivy will lead to abnormally low MMA readings suggesting an inhibited Transsulfuration Pathway.

[@omnimesh4096]

Should I supplement glycine or TMG? How do I calculate how much?

[@JohnDoe-os3mc]

would higher levels of b12, b6 and b9 increase the rate of conversion to methionine?

[@conqueragingordietrying123]

Hey John Doe, I covered that in this video: kzbin.info/www/bejne/g6jXpHRpbpaCkJI

[@TheShumoby]

I'm 46 and my husband is 50, both our homocysteine 6.4

[@nahidbodiz7053]

Can we reverse methylated DNA with TMG? If TMG helps with Methylation , does it mean it increases biological age?

[@chronicallywhatever]

No, TMG and methyl donors only drive up methylation. You would want to look into HDAC inhibitors such as butyrate or genistein, and DNMT inhibitors such as procaine or lidocaine.

[@lostpianist]

What are the role(s) of homocysteine in the body?

[@shaunm8692]

Ok, if you are on a budget, and want to reduce Homocysteine but maybe cannot afford a GlyNac (combo) supplement and need to choose between the 2 of them (Glycine OR NAC) : Which one of them is more effective (per mg) in reducing Homocysteine levels ? (specifically in the context of an elderly person - 80+ years old)

[@conqueragingordietrying123]

I'm not sure, but the only way to know is to test. Even if one makes a bet on one vs the other, testing to find out is essential

[@shaunm8692]

@@conqueragingordietrying123 Thanks for that !

[@darkhorseman8263]

There are a lot of factors that are related to homocysteine levels. Methylmalonic acid from protein digestion and metabolism, vitamin B12 status, P5P, Riboflavin, Nucleotide status, etc. There are many pathways that break down, and many unconventional nutritional deficits, with aging.

[@conqueragingordietrying123]

Yes, there are a lot of relevant factors-I covered a few of the pathways in the video, and am going after the most likely culprits first.

[@davidthompson8208]

This is interesting. As a part of my longevity protocol I've been focusing on increasing my natural HGH (similar to the TRIM protocol + DHEA and Berberine (sub for metformin), and my natural T levels... which involves a lot of weight lifting and protein intake on those days. Based on your note about that by product of protein digestion, would it make sense to up my B12 on those days as well to limit that impact on homocystine?

[@darkhorseman8263]

@@davidthompson8208 Methylmalonic Acid levels have been shown to be a big driver of aging, and shortened lifespan in people who eat high protein diets. Folate and B12 break it down, but supplementation with folate has been shown to make methylmalonic levels worse in old people, as opposed to young people, and they don't know why. B12 seems to normalize this dysfunction. Opening the door to the fact b12 and folate levels should be balanced in the elderly; folate in isolation, can make them worse.

[@conqueragingordietrying123]

@@davidthompson8208 I'm not sure, but doing the experiment, and tracking blood test results would be the way to find out...

[@hollyrotnes8743]

Maybe homocysteine increases with age because only the people with elevated homocysteine survive.

[@conqueragingordietrying123]

Survivor bias, definitely possible

[@azbat3829]

At the 7:50 mark you said you would have a blood test in Jan for glycine, after supplementing, what was the result?

[@conqueragingordietrying123]

Hey AZBat, here's that video (see 4:04): kzbin.info/www/bejne/rHy2f6umrbp1fJo Glycine didn't reduce homocysteine, tldr, but I'm going to start serine+B6 tonight when it arrives via mail.

[@ericoshea9382]

Fascinating. I really hope glycine is effective in reducing your homocysteine

[@conqueragingordietrying123]

Thanks Eric!

[@joeylodes]

A+

[@fine_gold]

too myopic. supplementing with 2g of glycine a day, missing a day and then supplementing with 4g, for 39 days, is not going to "lower homocysteine". glycine is used for so many different things, the 2g you took wouldnt be used on what you think it should be used on, its going to be used for collagen synthesis and neurotransmission

[@conqueragingordietrying123]

lol on the myopic, that's an interesting choice of words when considering the abundance of new hypotheses on this channel. Rather than what might happen, I did the experiment, and glycine didn't impact my homocysteine.

[@deep6301]

RDA??? REALLY

[@pierrejeanes]

No

[@conqueragingordietrying123]

It didn't in my case

[@ihbarddx]

A ridiculously large number of things are correlated with time. All of those things are correlated with each other. The Dow Jones average is correlated with time. Cumulative rainfall in the Amazon is correlated with time. Homocysteine levels are correlated with time. All cause mortality is correlated with time. So... Hell with glycine supplementation! Let's reduce rainfall - being careful not to crash the stock market, of course!

[@jeffrey4577]

❤

[@zerotoleranceforsataniceli4794]

Sorry but I thought Methionine should get converted into Glutathione, the antioxidant, in the liver, so adding in Betaine should be fine.

[@conqueragingordietrying123]

Methionine doesn't get converted into glutathione, which instead includes glutamate, cysteine, and glycine. Adding betaine will reduce homocysteine but increase methionine, which may be bad for longevity based on animal studies for methionine restriction.

[@zerotoleranceforsataniceli4794]

@@conqueragingordietrying123 OK, thanks. What happens to the Methionine? As you implied that can be over-produced by too much Betaine, so why is it that a problem ?

[@conqueragingordietrying123]

@@zerotoleranceforsataniceli4794 See this video: kzbin.info/www/bejne/Y4XIp2OvmKihd7M

[@zakhariahk.8720]

Glycine will help but it s not enough ...

[@conqueragingordietrying123]

I don't know if it will help, we'll see on the next text, but why do you think it isn't enough?

[@lindapestridge3073]

@@conqueragingordietrying123 Now i really want to know why Glycine might not be enough.

[@chrisc6494]

@@conqueragingordietrying123 Studies shows it has to be balanced, not enough as too much can cause lot of damage. I said it's not enough because other AA are linked with anti age process.

[@hai.1820]

What the heck?? You did not answer the question!

[@conqueragingordietrying123]

I didn't in this video, but in a video after that I mentioned that it didn't work: kzbin.info/www/bejne/rHy2f6umrbp1fJo