Autonomic Nervous System (Pharmacology, Receptors, and Physiology)

[@DirtyMedicine]

Errata: @4:27 I meant to write/say SALIVATION in the SUBMANDIBULAR GLAND for the Superior Salivary Nucleus. CN7 does also supply parasympathetic input to the Lacrimal gland as well.

[@Muhammadk6]

Dirty Medicine please cover LIPID LOWERING DRUGS next.

[@ayshasarmad1240]

@UC_BXx1XwqsEI1fHXFTGFOfw can you please explain the mistake to me

[@bobbygreene6924]

OK, it's a stretch for Mnemonic Muscarinic agonists, but METHacholine affects Bronc/Lungs, so smokin' METHacholine gets you in the right system. And this is even worse.......CARBachol ....Carbs and you have to butcher Glaucoma to GLUCOma like glucose. Truly horrible, but I'll remember 'em. Thanks for the vid.

[@pratibhajaggi7]

Plz cover opiods ans analgesic

[@alih6953]

Sorry you mentioned you had the sympathetic video of this see graft one. However, I could not find it

[@husnainahmed6716]

Pmeumonic for M3 locations “AEIOU” A: Airway E: Exocrine I : “Eye” and “I” sound the same when you say it O: the letter is circular so think of the GI tract as a hollow circular tube U: Urinary Tract

[@komaddog]

Can we really remember all the mnemonics we create? :(

[@user-kl7of2db6e]

I like that one!

[@husnainahmed6716]

@@komaddog lol worth a try

[@jerry-rsuprien4441]

that's a great one thank you @Husnain Ahmed

[@tanyasaxena1580]

Thnx

[@vanshajchandra307]

I wonder why do people dislike his videos. He is doing all this great work for free, you should be grateful people

[@Pikachuwhereareyou]

Just had the same thought. Makes me wanna fight them lmao.

[@tannerroberts1273]

I liked it so you have 69 likes :)

[@lynguy8824]

They jel much🤔

[@mostaanroya]

Because people are stupid, it’s in our genes 😂😂

[@wipegod9434]

One more spam

[@ligiafragoso9086]

This is the best summary explanation of parasympathetic function and pharmacology out there. I would have given so much for a lecture this clear during my preclinical years. Thank you.

[@DirtyMedicine]

Glad it was helpful!

[@pankajkalaiya4240]

He is doing a great job

[@irame5701]

Absolutely love this teaching approach - quiet, structured and intelligent: no screaming, drinking or eating, repeating 100 times. Thank you so much for the classical approach to the lectures! 🙏❤️🌷

[@bradm8454]

This is literal gold. This before the sketchy videos would be the ultimate way to learn these concepts.

[@89josegarcia]

I agree with you

[@christianbaker2582]

Watched this while driving to the testing center at 1.75x speed. Got two questions because of it. Great video

[@emmanuelogelle3965]

Wow. 2 correct question can be a difference maker

[@Dr.joshibanez]

GlycoDRYRATE Glyco: Represents glycopyrrolate. DRY: Represents its ability to reduce excessive salivation (sialorrhea). Rate: Emphasizes the therapeutic effect on heart rate control.

[@medicaldiaries]

Thank you

[@Samehxt5qg]

thank you

[@RACHMNV]

I say glycopyDROOLATE

[@wideeyewanderer1785]

I really want to donate, I promise I will, but you it will have to wait until I’m done because medical school is expensive but I will never forget. Someday I will reward you handsomely.

[@adeelsajid995]

Carbachol for Glaucoma: "I have a glock (GLAUC-oma) in the back (BACH) of my (mi-osis) car." Methacholine for Bronchial asthma test: "i got asthma from smoking meth". Edrophonium for Diagnoses of Myasthenia Gravis: "The ED (emergency dept) PHONes me to tell me about my diagnosis of MG".

[@Dks2114]

love these!! you could prob add ""I have a glock (GLAUC-oma) in the back (BACH) of MI OL[d] SIS' (mi-osis) car." hehe

[@jwhender21]

DIG Those ABS Over DUMBBELSS - muscarinic antagonists (Dicyclomine, Ipratropium, Glycopyrrolate, Trihexyphenidyl, Atropine, Benztropine, Scopolamine) used for stoping: (diarrhea, urination, bronchospasm, bradycardia, emesis, lacrimation, sweating, salivation)

[@debigdogk9563]

This is the best . Wonderful and thank you 🙏

[@Sandeep-lw7cu]

nice one

[@curium4026]

Urs is the only channel where I watch ads. You kinda deserve them.. Thank u

[@chumadoshi6987]

ME TOO!!

[@arzoo2sehrawat]

ME THREE!!!

[@dr.rehmatsafdar1578]

I have spent thousands of rupees on apps for studying medicine but none of them have helped me the way you do for free... I don’t know how you guess but your videos cover all topics I have a tough time learning... So thank you ... love from India ❤️

[@Sasukeloverxxx]

BLESS YOUR SOUL. THIS is what I've prayed for and needed, especially with STEP around the corner.

[@s.fraser5221]

How did it go?

[@navintiwari9532]

one of the best videos i have ever come across. IN a shorter span of time almost all the important and vital aspectcs have been summarized in excellent method.Great........

[@jaxonvictoria4345]

Intern pharmacist here, thanks for this quality lecture. Been refreshing on ANS pharmacology for the NAPLEX/CPJE and this has been very helpful.

[@lifelessons1999]

Now I m intern in 2024 and watching this

[@hakankoca2917]

Oh, Dirty! I really appreciate that. This is exactly what I need! You are amazing. Keep it up the great work. Thanks A LOT!!!! Give him the thumbs up guys.

[@aishbala]

you're a godsed. this was SO good. i keep forgetting every time i understand the ans and i have a feeling this one will be the one that sticks. so wish i saw this in my preclinical years. THANK YOU!

[@sakinaNP]

I have been trying to understand this for the past 2 years. FINALLY I understand. Thank you Dirty!

[@nursenelly72]

I’m an LPN and this is quite helpful. Thank you so much!

[@chandanaabayasekara1976]

Thank you so much ...very productive lecture ...until today I have lot of confusion about autonomic nervous system....but my mind is very clear now Thank you So much From Sri Lanka

[@tayanemelo7915]

i'm from Brazil, student veterinary medicine, i'm lovelyyyy for your work. congratilationsss

[@justinkacyon3444]

TrihEXPhenidyl- EXP- EXtraPyramidal

[@damodarwilson8329]

For trihexphenidyl , the hex makes me think of hexagonal pyramid. So trihexphenidyl . Use extra pyramidal side effects

[@beaudaciousbrownies]

I always said “TRI a HEX to cure your Parkinson’s” 😂

[@ojodeborah4620]

Wow! That's just on point. Thank you.

[@lifestylemedicine2501]

The ABSOLUTE best video I have come across explaining this topic! Do you have one on Adrenergic receptors?

[@michaelpolchert9367]

Trying to help with glycopyrrolate mnemoninc...for any greeek root fans out there - salia in greek means saliva; glyco is the root for sweet - so there is a connection there sweets make you salivate...

[@veesridhar7601]

I don't even understand how else to thank you for this video. This helped me SO much! Appreciate it, thanks!! :D

[@TFrenchHughes]

TRI riding the BENZ into the CNS. (BBB looks like a dashed line) (driving makes me think of EPS jerking the wheel)

[@DirtyMedicine]

!!!!!!

[@childemperor7475]

Ur a mini dirty I love it. I had some crap like I TRI BENZos but they fucked up my head. But yours adds in the eps portion and that's fricken gold

[@zimuzoradaeze8336]

I wish I had come across these videos a few months earlier. You’re doing an amazing job. I’d definitely support your channel once in start earning. Keep it up.

[@penguinshoes7928]

The 3 slice pie logo of Mercedes Benz forms triangles, like the face of a pyramid, a triangle, as in TRIhexphenidyl. Triangles, like pyramidal cells. It's an easy association to view the 'Benz' or 'Tri' with pyramids and pyramidal cells, possibly more so with the well-known car logo.

[@arzoo2sehrawat]

Good job, this is awesome

[@MarvelousMomah]

Very specific and understandable. I was finding it hard to understand but watching this has improved my understanding. Thank you so much You just gained a new subscriber!!!

[@pershielamabale4622]

Been looking for Pharmacology videos that uses charts and graphs. Because it helps a lot in my memorization. Thank you for this!

[@taiaburrahman9380]

Please make a video on PCR,CRISPR Cas, Microarray, FISH, Flow cytometry,,I m eagerly waiting for Your reply. Thanks for all your hard work.

[@austingrist7467]

CARbachol: "My glaucoma is better, I can drive my CAR now"

[@sukhjinderbhatyal6252]

❤

[@medicaldiaries]

Thank you

[@sh-ka3211]

Xoss

[@PS-pr5py]

Great Vid as usual! Thank you! I use "hit of meth, short of breath" for methacholine and "carbachol, don't hit a wall" (you can see) to keep them straight. Meh memory aids but works for me.

[@yes7855]

good ones imo, thanks!

[@Iuzishah]

Man!! You're literally saving lives 😅

[@healthwire.pro860]

Amazing. I am studying for my Psychiatric ANCC board certification exam and you videos are so helpful.. Thankyou.

[@degoldessie1826]

He is the best educator. Kudos dirty

[@angelica.6073]

What video did you recommend for sympathetic high-yield points? Thank you so much, this video helped me A LOT!!!!

[@janenabasinga1958]

This is so perfect. Thanks. Greetings from Uganda

[@degoldessie1826]

No KZbinr MD was able to such difficult concept in to practical & useful. 🎉❤

[@vijaykota4444]

thanks for your effort in helping us making a better doctor. this video is extremely helpful. all the love and support.

[@arth1234]

Perfect timing, was just about to review this! Thank you for your amazing videos as always!

[@22yellowstreet]

I do be crying on my pillow at night because of how good this video is !

[@sweetcandygirlhe8966]

preparing to take licensure exam, and your lecture videos help me A LOT for free! thank you so muchhh!

[@skyglad2260]

it helps. and very simple explanation. best to get the general knowledge.

[@nbme-answers]

you da man dirty dude! 2021 and still pumpin out the goods!

[@ladyfree3492]

I just discovered this channel OMG its so helpful thank you very much I will watch all the videos

[@mankwerabotho2001]

at 4 minutes, i already feel i am at the right place for the topic. thumbs up

[@nadapenny8592]

I have very little idea of what I'm seeing here but it makes enough sense for me to understand why certain medications are prescribed to me and why they do or don't

[@SaadNagi12]

this video changed my life

[@ahmedalsadi0010]

This man deserve all the money that i was paying for my hall years in university

[@MOHAMMEDALFILQI3145]

30:20 they have the suffix STIGMINE not only STI

[@goodvibe1380]

32:18 Another way of remembering it is by thinking A donkey (Donepezil) kicked a guy in head > He lost his memory. (Alzheimer's) For Pyridostigmine and Edrophonium, I just think of a guy visiting PYRAMIDS (Pyridostigmine) wearing HEADPHONES (Edrophonium) and discovering MAYAN GRAVES (Myasthenia Gravis)

[@SaffyKaffy]

Great Video! Thank you so much for making the system/drugs concept easy; I am currently in NP school and appreciate your presentation!

[@crazysingerr]

benzTRopine & TRihexphenidyl used in treatment of TRemors

[@hiraalptekin8762]

for benztropine and trihexphenidyl- benz is mercedes-benz so if a patient shows up with tremor it can be related to a bumpy road(tremor) while driving a mercedes and it is a strong car(stiffness) and trihexphenidyl has tri in it and this is for parkinson disease and it has 3 major symptoms- bradykinesia, rigidity and resting tremor so we cover 2 things at once

[@jordmanbatgod]

"Ipratropium = Inhaled" - both start with 'i'!

[@googefacts7389]

This is so awesome! It took me just one minute to realize how useful your video is and to hit the subscribe button. I expect more pharmacology videos. Thank you!!

[@AnImprovActor]

For pilocarpine I just remember it by knowing all cholinergic agonists have Chol except carpine. And Carps have ry eyes and mouths when they are out of the water. So this med treats that specifically.

[@mohammedelsayed3262]

Thank you very very very very very very very very very very very very much Excellent work

[@ChristianFerrel]

I wish your channel existed in 2016 when i had the pre-clinical module on this. THat lecturer was horrible and i didn't understand anything. Now i have to go through all of them again in final year and thank god i run into your channel.

[@DirtyMedicine]

Thanks for being a Dirty Medicine member :)

[@catiefrye2815]

"PHONe your doctor to test for MG" EdriPHONium

[@abheeksharma987]

Omg i just had the similar thought

[@HadassahGH]

Better explantations than my postgraduate provider! Awesome

[@ajaabai9850]

Dirty! You’re simply a brilliant mind. It’s important to get this big picture first before getting into the nitty gritty! Thank you!!!By the way, are you Canadian?

[@ajaydobhal2489]

Very nice vedio ,well explained hope for more such vedios

[@exemplarypersonality6562]

Very useful video. it improved my understanding.

[@Avoug]

For Tiotropium > "Tie" goes around the neck > Makes it harder to breath (Asthma, COPD)

[@Sasukeloverxxx]

Will you be making another video for the sympathetics? I know there's the chart one but for the receptors and stuff like with this one. Thanks for a sweet and to the point vid!

[@masterimbecile]

He has a video where he shows the BP/ HR tracings for Epi, Norepi, and Isoproterenol. That's most likely what's gonna be tested on for strictly sympathetic stuff. The rest can be derived from this vid.

[@alih6953]

@@masterimbecile Sorry do you have the link? I cannot find it. Please help friend

[@yes7855]

@@alih6953 same

[@enyinnahchidinma576]

Been trying to understand this for a while. Thank you.

[@Al-NoorMedics]

Great 👍

[@choochies]

@DirtyMedicine for Edrophonium maybe the pneumonic could be "we need to see if Myasthenia Gravis is phony or not." Since we are trying to confirm diagnosis for MG with this med.

[@DNP820]

Thank you for helping me learn more while in nurse practitioner school!

[@drkrunalpatelortho]

B for bladder retension Bethanacol C for like cornea So use in eye

[@nneehhaal]

YOU ARE AMAZING I WAS TRYING TO STUDY THIS FOR A WHOLE MONTH

[@okidokidoc]

Thank you so much for this pharmacology series!truly helped me survive med school ❤️❤️❤️❤️❤️❤️

[@Rena0530]

could you please do a video on neuromuscular blockers (depolarizing vs nondepolarizing)? Your videos are amazing!!

[@hodabahmanoff7835]

For alzheimer's: DON't forget ( cause you have alzheimer's) the GALA dinner on the RIVer ( DONEPEZIL, GALANTAMINE & RIVASTIGMINE) And I think all the great stuff happens on the pillow and they all cholinergic: erection stimulation, sweating, salivation, and lacrimation (cause some people burst to tears after they COME. and watch your videos)

[@hodabahmanoff7835]

For MG, I use the Matrix movies. NEO, FIGHTS for people's lives and use PHONe RIDe. And that would be NEOSTIGMINE, PHISOSTIGMINE (fights for lives as antidote), EDROPHONIUM (they could identify each other), PYRIDOSTIGMINE ( use the phone as a ride and disappear)

[@tantricsphinx]

Thank you for the mnemonics. Also, the opinion piece is solid.👍

[@matrioszka7899]

great work ❤

[@annad6619]

Thank you 🙏🏻 we need more biochemistry videos please 😓

[@elhuda868]

This was Amazing, Chukraaan!

[@samiaarif230]

Very informative video.. Thankyou so much 😊

[@medstudent777]

Best explanation ever!! Thank you so much. I can't find the video of the sympathomimetic drugs😅

[@shermeen1517]

Mnemonic for Benztropine and trihexyphenidyl "Tri(trihexyphenidyl) PARKing (for parkinson) my Benz (benztropine)

[@Gela-e7t]

WOOOOOOOW,awesome man!!!!!!! Thank you one million times!

[@jayvodela]

excellent explanation for sym and Parasympthateic

[@aiyshaamjad6346]

This is literally exactly what I was looking for THANK YOU SO MUCH

[@wardahrana6412]

is there a Sympathetic nervous system video?

[@arnabsarkar.Med.4213]

Did you find it?

[@clariceallierodriguez8103]

Thank you so much! This video was very helpful🥹

[@ojodeborah4620]

Thanks for this video. It's so helpful and timely!

[@ironyynori824]

Hey man awesome video, really appreciate your high yield content!

[@mashoodabbasi7288]

Ipratropium could be I-Pray, I-Breathe (since its a M3 antagonist and cause bronchodilation)

[@StellaNoire]

Thank you sir for all your hard work

[@ayesha2014]

AMAZING AMAZINGLY AMAZING WORK !!! ABSOLUTELY LOVED THIS !!! THANK YOU FOR SUCH AN AMAZING REVIEW ON SUCH A HIGH YIELD CHAPTER. Hoping to learn more from you soon :)

[@jalaluddinshaikh6860]

😊😊😊

[@susanetiendem8719]

Glycopyrrolate; gliding secretions (for Drooling)

[@sofieelamine880]

kindly do a video for sympathetics nervous system drugs ♥

[@janebenz8425]

Hi Dirty, great video, appreciated......from Kenya!

[@oraena5526]

plz make more pharmacology videos... these are amazingggg thank you sm for everything

[@DrA902]

Dumbbelss 🫣🦦💕 Diarrhea, urinating, misos ,bronchial contrition ,bradycardia, Excitation of skeletal muscles and CNS followed by depolarizing neuro- muscular blockade, Lacrimation, Salivation and Sweating

[@ellimacbyun1324]

Thank you so much for this! I finally understand it more. So happy I watched this vid!