Metabolism | Cholesterol Metabolism

Official Ninja Nerd Website: ninjanerd.org
Ninja Nerds!
In this lecture Professor Zach Murphy will be discussing cholesterol metabolism. We describe the various enzymatic processes involved in converting Acetyl-CoA into cholesterol. We also discuss the regulation of some of the more important enzymes in this pathway as well as their relationship to pharmaceuticals (statins). Finally, we talk about the use of cholesterol in bile salts, steroid hormones, and lipoproteins. We hope you enjoy this lecture and be sure to support us below!
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#ninjanerd #CholesterolMetabolism #Metabolism

[@Mariam-nv1fk]

I suggest that by the end of the video, zoom out the camera to the whole board to take a good screenshot 😍👍🏻👌🏻👏🏻

[@satyabratasingh3824]

Yes man, you spoke by heart out!!😂😊

[@navaneeth_us]

Hands down to this comment!

[@shahbaazahmed5365]

They do provide ss for some of the lectures,if you are a patreon 🤦🏻‍♂️

[@graceremo5724]

exactly!!!!

[@graceremo5724]

I'm struggling to have the screenshot for the whole whiteboard hehe.

[@unzillaahmed]

How did my parents or everyone before internet came, even studied? Thank you! Massive help

[@joeybacus6734]

Simple teachers that time teaches the same way as this... the invention of powerpoint doomed the educational system

[@jeremiahgounder9223]

@@joeybacus6734 bro you're right, and this is so sad

[@cendre6724]

@@joeybacus6734 right on.

[@ridwansalifu6987]

@@joeybacus6734 yh bro

[@nithyasreesathyanarayanan5611]

@@joeybacus6734 Yeah that's true! But powerpoints are like only useful for final revision times, not for actual teaching.

[@nero91]

Since this will be the last video before my biochem exam: Thank you. These videos were fantastic, I have now watched all of them except the detailed ETC ones. If I pass, it will be in large parts thanks to you. But could you for future generations also do a video on Pyrimidine and Purine Synthesis and Degradation? I did pass. Currently doing state exams

[@noaamaallana8263]

How did your exam go? I have mine on Tuesday and he has helped me through the course of biochemistry, he is legitimately my biochem hero!

[@lumpyspace5919]

😭 I have mine in 2 days, this channel has honestly helped me so much to understand biochemistry, I also agree that for future purine & pyramidine synthesis would be helpful and haem biosynthesis

[@maxh1964]

Tell us how it went!!

[@hamzaashoaib4644]

I guess it didn’t go well after all :(

[@jeremiahgounder9223]

@@hamzaashoaib4644 how can you say that may be he has blocked his notifications of YT in his phone.

[@saram5354]

you are saving my medical career

[@Pro0osh]

Whenever I hear “Alright ninja nerds” I know that I’m about to get a grasp on a new subject :)

[@tsisanaugulava95]

Dont know why I am writing this right now , but my whole group adores you for making out biochem so easy ,especially metabolism . Our good grades are all because of you , still rewatching them ,because of how good your speach and knowlige are.amazing.

[@harriskhan8146]

9:16 he sat on his knees to write for us. Periodt😭😭😭😭

[@jeithrowagwag1425]

Sometimes I wonder why you're talking fast, but then I remember I sped up the video 😂😂

[@olamuawya]

😂😂😂😂😂✅

[@shanzhang9685]

As a young faculty member, I am watching your videos to get some inspirations before I go into class teaching my students. Great great videos!

[@prakritisingha3186]

You are single handedly saving my medical career dude!!

[@petrsymon3872]

This guy just makes everything look simple. Thanks prof. Zach

[@bilqishkaridza7413]

thanks harper’s hero! you make my biochem way more fun to learn and more logic

[@NinjaNerdOfficial]

+aliva riza i'm so glad that we were able to help you!

[@longlivethebook5877]

Love the whole metabolism series. Thank you, Zach!

[@jeremiahgounder9223]

Is his name zach?

[@its_Dr.Glass-Man]

I am glad that this family is growing day by day. I wish all the world to watch your masterpiece. It is not helping , it is saving me right now❤❤❤❤❤

[@renukatewari9143]

"Let's number all of these puppies" LOL. Another awesome video professor!

[@Zochtheconqueror]

The fact he uses words like that makes it even more better

[@emilyfisher9584]

Somehow you have managed to teach me more in 28 minutes than any medical school professor has taught me in 6 weeks.... I try to give them the benefit of the doubt but the way you lay it out makes everything so much easier to digest (Ha!). I truly hope one day you are paid a trillion billion dollars cause you deserve it

[@Africanlubo]

Tomorrow morning is my biochem exam. Thank you. These videos were fantastic, I have now watched almost all of them. If I pass, it will be in large parts thanks to you.

[@fatimafaiz7344]

How does exam go

[@Africanlubo]

I passed 😊

[@Pro0osh]

It’s never too long to watch your videos... No matter how long the video is, it always filled with very high yield information...

[@totakyungsoo495]

gonna recommend this to all my friends , wow bro we r struggling here with our biochem prof. thanks a lot !

[@faryalgohar4744]

BY watching this, the whole idea about cholesterol metabolism is cleared. Thank you

[@supra_gliflozin]

Your stuffs prove again and again the fact that the best things on Earth are for free !!

[@ayakechout7108]

Omg thank u so so so much I have an exam in two days and I was struggling with cholesterol and your video helped me A LOT wish u the best of luck , god bless you 💕

[@emanuelgrant4335]

Hey man, really appreciate the lecture. I only can hope for more. You have a great and succinct way of explaining things.

[@NinjaNerdOfficial]

+Emanuel Grant thank you so much for your kind words!! We definitely have more videos coming soon

[@Ghostofsparta22]

The same lecture that my teacher made me sleep u made it really interesting 😅love u man for what u do the best teacher in the world

[@chessymsafiri4267]

Exactly😅

[@jueunryu4999]

You are explanation is always clear and helps me fully understand! Thank you so much Mr. Ninja Nerd - from Korea

[@matiasnieto5112]

duuude this is too good to be true! thanks A LOT from chile!

[@miriamcampillo7459]

I am going to pass the exam :')))

[@NinjaNerdOfficial]

We are so proud of you!

[@dimitratsil.7427]

great explanation !!

[@isra4749]

Thank to god and u i 've passed the exam easily without even assisting at university we need someone like u to teach us there you're my biochemestry hero!!! thank u so much please add french subtitles for us we study in french in algeria and please what's your secret to memorize all this informations ??? i wish more success for u in the near future keep going!! we need your help. thanks again

[@razor48391]

You've saved my ass on multiple occasions you magnificent beast.

[@robertwillis2314]

Amazing video. My only concern in all of this is the fact that as a medical profession we insist on pushing statins on patients along with often many side effects to lower their cholesterol. Do statins lower cholesterol, undoubtedly yes. The bigger question is though why do we consider that to be a good thing. Study after study has shown that higher cholesterol levels are protective against stroke, CVD and all cause mortality. Women's health initiative, Sydney heart health study to name just 2 but there are many more. I suggest if you are interested in this then cardiologist Nadir Ali and researcher Zoe harcombe are a good starting point then maybe someone will figure out that statins are doing more harm than good. These have been around for decades and if they work as we hoped they would CVD would be on the decline. Maybe we got cholesterol wrong. Common sense to me says that the liver wouldn't go to the trouble of making cholesterol if we didn't need it!

[@marynguyen6417]

I ve been on a ketogenic lifestyle, and understanding the lipid and cholesterol metabolism is of great interest to me. I will be watching the rest of your videos on this topic, and perhaps others as well. Thanks again!

[@DrinkColdWater]

in the oral exam i have for biochemistry i am gonna say that zach from ninja nerd also think its redicoulus to say all the steps for cholesterol synthesis😂

[@cindydzobo5925]

I enjoy this content so much and recommend it to a lot of my other friends who are also studying Health Sciences. Your enthusiasm and passion for your work really makes the work so engaging and easier to gauge. You are and amazing teacher. Keep it up, man!❤👌😎

[@teamammcri2224]

Please make a vedio on regulation of cholesterol synthesis.

[@heypauly2002]

The fact that within the next few years you can go to med school for free just by sitting around watching KZbin videos, is amazing. And this is probably one of the best sources I've seen.

[@BarberNick]

Great job and very informative! But I want to notice that the LDL is not "BAD CHOLESTEROL"! It's a very important molecule,as you've mentioned in this wonderful video,for cells life.

[@erastvandoren]

LDL is atherogenic, as are all ApoB lipoproteins.

[@BarberNick]

Obviously i respect what you say but disagree with the term "atherogenic" because the LDL is only a molecule that produced from our body(liver) to transfer lipids wherever our system needs!Now, if our body oxidized ,for a couple of reasons, our lipid molecules(LDL) it's not because the LDL is "BAD" but because of our choice to what we eat-think-doing lead to oxidative stress producing free oxygen radicals which in turn oxidized our lipids and other important molecules etc. I don't want to agree with me but I like the dialogue (Free speech,expression etc) For these reasons thank you very much for your response!

[@ritishdhillon_]

bro really asked why the cell membrane is important . honestly I never could have thought that someone can even make biochem fun to study . Thanks for putting all those efforts

[@neelhinsu7971]

We need more videos like this on pharmacology

[@Juvenilemedic2024]

❤THE BEST TEACHER I HAVE EVER FOUND ON KZbin ❤❤

[@namidabi5877]

i swear to god, you're the only person who can make me believe that biochem and metabolism is beautiful

[@emmanuelmusajja5934]

This video is good

[@desaibha]

wow!!! such. a wonderful presentation. detailed ,beautifully illustrated,. learned so much. going to watch all of your videos. please, keep doing exceelent service by educating us.

[@shailivr2229]

yeh my pharmacy lectures just rush through this and I always forget it so its nice to have this to come back to :)

[@rizwanilyas4289]

I expect a call from president to appreciate u because u have done a heroic thing And thanks for helping students

[@larunsikofoworolavictoria855]

Thank you, Ninja. You just saved from having a complicated study time. Thank you for simplifying this. Thank you!

[@alexmartinez3683]

it took 2 years, but I finally understand all of this

[@rachelmmbaga8]

thank you soo much ......you have been always helpful to me ever since I started my med school

[@bhagyaperera5672]

Thank you NINJA NERD!

[@thephoenix85]

U r an alien bro.. out of this world.. legendary stuff there.. salute.. 👍

[@jaanthecat-ooo5150]

i luv this guy with all my heart for making life easieeerrrr😭😭😭

[@youssefislam5310]

thank u so much all the way from egypt

[@akhilamalu4546]

i realy liked your videos . its really helping me to concentrate and understand every single thing . thank you so much

[@PaladinoBiologo]

Thank you from a student from Brazil!

[@disohs4100]

You are a life saver thanks a lot !

[@wretched00]

Very much helpful before the last hour of exam... I just gave up learning such a complicated course, biochemistry.... But, you have helped me to start again...

[@westfield90]

You should have a million subs

[@saidfarid6382]

Hello dear Doctor Thank you so much for your interesting information about Health,i do appreciate your job.I wish you peace and happness under the sky of prosperity. All the best. Take care and have a good time. Your Student from Algeria.

[@mehmeteminbayram1653]

That’s what i have been looking for. The thing that you are doing sir is brilliance

[@tendaisangoya160]

You always make it much easier to understand..Well displayed👏

[@hawraaalhilali1092]

Big thanx doc.

[@CollinBennettMD]

You're not just Harper's hero, but my hero too :)

[@fgnsdfnbnd]

Fatty acids from the intestine over 12 carbons get packaged into chylomicrons (apo b-48) and are taken up by the lymph system and then dumped into the subclavian veins-> into blood circulation->dump some FA's to mcle and fat-> then go to liver. FA's from the intestine with 12 C's or less (eg. vinegar or coconut oil) get absorbed directly to the liver via the portal vein. Correct me if I'm wrong. Good videos.

[@NursePhiri]

Excellent work, prof thanks

[@kondalakshmi230]

Thanks for making biochem metabolisms easy for us 😊 hope u do more videos for us 💗

[@abdouboumediene655]

life saver thanks professor

[@daniellekniedler5425]

Amazing instruction. Thank you, Zach, and your team for access to this education. 🙏🏼 🧬😅

[@maulikmehta7461]

Making Biochemistry Fantastic is the goal of this guy!!!

[@mehmetozben562]

Thank you, Zach!

[@dranthonyasturi9790]

A MASTER LECTURE FROM A SUPERIOR MIND

[@nas_775]

thank you so much, these are the best videos on KZbin!

[@musicheart5496]

Love from INDIA 🇮🇳 ♥

[@maronkimbugwe-ce2gb]

For real u Ninja mhaan n I feel like no need of reading books coz u ma book. ❤ from Uganda

[@zainab-dr9sy]

You’re literally saving lives of med students, i rlly appreciate the hard work u and ur team put in each single video! Tons and trillions of thank you won’t be enough🫡🫡

[@aadyajha6751]

Thnkuuuuu @Ninja nerds for making such great effort for us !! 💕💕❤️❣️

[@mateuslacerda284]

This guy is a genius. Congrats from Brazil!

[@DaniellaKelechiAgudosi]

Thank you so much Zach

[@learn4307]

Thank you so much 🥰🥰

[@lazarousmumbi2759]

thank you so much

[@mairakhan4318]

Thank u so much ur lectures is so easy thanks alot

[@zainabs4159]

this guy is a miracle

[@kombatpatrick2791]

❤❤ I had a good time following your lectures ..thank you so much for your commitment taking time to explain things better for us

[@kalpanachauhan2327]

Thank you Ninja Nerd ❣️ You made Biochemistry easy!!! Great Job 👍

[@lorienjohnson9721]

your videos are super informative and i love the little funny bits “eating too much burger king” lol, keep it up man you’re helping a lot of people! thank you!

[@clintonelliott9044]

Dude I love your videos. I just started a Med degree, and your videos are getting me through :)

[@lakshyagupta7472]

Thank you so much for such a great vedio 🇮🇳 🇮🇳

[@aisharasheed266]

Great explanation! You made it simple and authentic. Keep it up!

[@tareqnajjar5362]

super well done ! thank you for the wonderful explanation of such a complex topic

[@depharmily2064]

thank you ,much love from South Africa

[@samanashetty7331]

I'm quite impressed by ur vedios!cudnt think biochem cud b this interesting god bless!!1

[@Omartabyaoui]

People who type like you dont deserve to be doctors

[@user-re3cm4pl7g]

Very appreciated for this wonderful lecture. Thanks Zach.

[@rwepie4041]

seriously thank you so much i wouldnt be able to pass without you

[@oliviataifalos1599]

These videos explain metabolism way better than my lecturer, I might actually pass this exam now

[@aishakabirumar6078]

Hey prof you’re the best, Keep on the good work

[@epedersen5824]

Beautiful video, but again statin has NOT been shown to prevent cardiovascular diseases. However I like you brought in the HMG CoA reductase to show what influence it 🙂🙏

[@yaninayurchenko5261]

I love your lectures, thank you for making them so easy to understand

[@sabrinams2325]

Please also make a video on vitamin metabolism

[@Rob-ch8fy]

I love u so much ❤️❤️ U made it very easy to me 🙏🏻

[@NinjaNerdOfficial]

+3usai Kalasher that's awesome news I'm so happy that we were able to help!

[@themanthemythlordcliffern4708]

Very helpful! :)

[@UghanthiniiKaliyappan]

Hi Sir. Your videos are really helping us to understand the lectures and topics. Looking forward for the video on Regulation of Cholesterol Metabolism. Thank you.

[@marynguyen6417]

Great educational video, on an extremly important topic. Thanks so much!