Topoisomerase 1 and 2 mechanism

Topoisomerase 1 and 2 - This lecture explains about the topoisomerase 1 and 2 mechanism of action. Topoisomerase 1 enzyme cleaves single strand of the DNA and can change the DNA linking number while the topoisomerase 2 can relax the DNA by creating negative supercoiling by cleaving both the DNA strands at the same time. This video lecture explains about the topoisomerase 1 mechanism and the topoisomerase 2 mechanism to relax the DNA by changing the DNA super coiling.
Type II topoisomerase cuts both strands of one DNA double helix, passes another unbroken DNA strand through it, and then reanneals the cut strand.
Both type 1 and type 2 topoisomerase are of 2 types.
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Thank you for watching the video lecture on Topoisomerase 1 and 2.

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Understanding concepts has never been easier. Thank you so much for making these important concepts so lucid.

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Was trying to understand this for the past 3 days, and today only 17 mins and cleared the entire concept. Sir you are great.

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[@bts_rollercosterlifepurplearmy]

Nobody wants to stress... Yes you are my Topoisomerase relese my stress during exam 👍👍

[@shomusbiologyofficial]

Yes. Indeed

[@Lorient121]

Such a beautiful mechanism. Topoisomerase is the tailor of proteins

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In teachers your are all in all sir. Thank you, it was very helpful.

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Very simple and clear explanation. Thank you for making it simple :)

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[@lucygomango899]

Sir i really understood this DNA topoisomerase . Thnkx a lot of u sir 👏👏💐💐💐 From.........odisha

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Bro what's your educational qualifications can we know? Really comprehensive explanation.

[@shomusbiologyofficial]

Msc. In Microbiology

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R u doing PhD in microbiology 🙄

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Onek onek dhonyobad aapnak🙌✨

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A best mentor kindly share your notes of lecturer...

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Excellent 👌

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Thank you

[@monikaluthra339]

Type I topoisomerase has 2 subfamilies typeIA and typeIB Type II topo has 2 subfamilies typeIIA and type IIB

[@oligoli6209]

nice lecture ....and u make my concept clear during exam .......so tnq once again

[@malikid1000]

Do you have a video on topoisomerase inhibitors.

[@CreatorNasir04]

what a explanation i can't tell you that.But this video really help me out thank you sir .

[@ghazal.m6071]

It is very complete video,thanks. I have one question. Gyrase convert positive coil to negative?

[@kuriyaridhi1867]

Thank you shomu sir

[@devanggondaleeya4321]

What is the meaning of negative supercoiling?

[@ravaliyerramsetty4649]

Thank you sir

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You're welcome

[@ericfontana462]

9:32 How I feel about my professor who originally made this such a confusing concept.

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Lmao same fam

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Watching this video Just for tomorrow Exam

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Sir tqqq soo much your explanation ISS awesome it's easily understood tq for uploading sir

[@shop2012]

Your videos are very helpful!!

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+shop2012 thank you.

[@malakismail160]

i have a question. does topoisomerase work only on circular dna or it can work also on linear one? please reply

[@Drawtine]

It can work also on linear one

[@vivianebrandao666]

this is great, thank you!

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You're welcome

[@Priya_P.R]

No. Topoisomerase type IA comprises 3distinct classes and one of them is topoisomerase III

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+naeem m-m you're welcome

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+nerd nerd thank you. Glad you liked my lecture

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+nerd nerd thank u

[@Bumble-bee_]

I cannot find the separate videos of topoisomerase 1 and 2

[@shomusbiologyofficial]

Coming soon

[@Arya1924-c1z]

Negative super coil fevour unwind the dna?

[@sonal6662]

Sir Exact Topoisomerase ka function kya h plz in simple language and also tell me about DNA gyrase

[@SURPAHELI]

very nice thank you sir

[@toheedkhankhan9582]

Thnku so much

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Nice language easy to understand

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Darun bujhiyechho.

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Thank u so so so so so much!!

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Helpful

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Thank you

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May God bless u....

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Thank you

[@sreenathholla2317]

Hey, so the topoisomerase 1 only involved in the cccdna cellular process, right?

[@subhrabanerjee7522]

Which enzyme removes the supercoiling in eukaryotics?

[@shomusbiologyofficial]

Topics type 1 and 2

[@akankshyasamant3310]

Sir in pathfinder book it is mentioned that enzyme with odd Roman no. After their name are type 1 and with even no. Are type 2, so which is the correct one?

[@asingh6073]

Yes. I have the same confusion.

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ur smart love ur videos:)

[@devanggondaleeya4321]

What is the difference between DNA gyrase and topoisomerase IV? In bacteria

[@shraddhamohapatra9207]

DNA gyrase is Topoisomerase II acting as a swivel to induce negative supercoiling from positive. And topoisomerase IV is responsible for termination of DNA replication

[@kalpanameena9854]

I don't think that is correct... in the second part of the video the primer in the loop…when you imagine you straighten the loop out... than the primers in both chains will be in the same direction….or…leading strand is 5‘ (on the left) - 3´(on the right) so lagging strand is 3‘ (on the left) than on the end of the loop it should be 5‘ ....but primer on it starts also with 5‘…Still thanks for your videos, your teaching helps me a lot!

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[@nifatjan760]

sir wht iz the reason behind...Passing one strand throug the double nick....?

[@shomusbiologyofficial]

It's to resolve the supervoiled state and relax the DS DNA

[@bosonsbotany9934]

sir plz plz plz make a video on sedimentation of pulse label n pulse chase. I'm very confused with this topic :((

[@shomusbiologyofficial]

+bosons botany sure. I will try to make a video on that topic

[@bosonsbotany9934]

thanks sir

[@chandnisingh4526]

Thaanks

[@devanggondaleeya4321]

Please use 3 dimension and explain it sir

[@genomelifescience2614]

Good morning sir I am ur old student when I met u in Bangalore there was only 4 students 3girls and a boy(me). I m missing u sir. I have a doubt that how dna polymerase distinguishes between dntps and ntps pls tell me sir

[@shomusbiologyofficial]

I remember. How are you now?

[@thakurankit7159]

there are some aminoacids in the nucleotide binding pocket of dna pol(in the palm region of dna pol)called discriminator amino acids which helps to distinguish between dntp and ntps

[@arshadhussain2083]

Thanku.....Suman Sir........💓💓💓

[@luisfobo]

Does topoisomerase come before or after helicase ?

[@kamaljeetkaursandhu2976]

After

[@veenamvenkatakrishna7970]

Sir why topoisomerase induces negative coiling

[@shomusbiologyofficial]

To reduce tension and structural stress in the DNA

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sir pls explain topology..

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In Hindi plz

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Will come later

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Hindi me

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you better speak hindi.. making easier for both

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I am not a native Hindi speaker

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plz exam in hindi also

[@rudraseth5419]

Insufficient knowledge. Lake of knowledge

[@malakismail160]

i have a question. does topoisomerase work only on circular dna or it can work also on linear one? please reply

[@mrscientific4826]

Both