T cell maturation and differentiation - thymic selection | T cell development 2

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Shomu's Biology

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i clearly understood T cell maturation after watching this..thank you Sir

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[@dr.anantsapra1114]

Very well explained. Kindly teach this part before tcell activation process for proper sequence. And do segregate positive and negative selection events (which u already explained in a diffused way) . Keep it up! ❤️

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I love this vedio😍😍finally i came to know what is exactly maturation of t cells🤘😎

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+Shweta Shinde glad I can help. Stay tuned and keep watching

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thank u sir for such a great lacture i just love the way you used a coloured marker 😊😊😊

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[@hardz2110]

Just to confirm, when the thymocyte comes in through the HEV it will be CD4-CD8-, the t-cell receptor will begin to form via VDJ recombination, and then they will interact with the thymic epithelial cells to become CD4 or CD8 in the inner cortex and this is where positive selection happens (with MHC I or MHC II) becoming CD8 and CD4 respectively --> then in the medulla they'll undergo negative selection with dendritic cells or medullary thymic cells (these cells have peripheral antigens which induce the negative expression) --> then they go on to the lymph nodes or in the blood as naive T-cells awaiting to differentiate in T-helper or cytotoxic T-cells I hope this is right?

[@FarhanFarhan-kw7cp]

Bro, can u explain the concept of MHC restriction? Like why some cells cannot bind to the mhc, even though they have the same tcr having alpha and beta chains !!

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Nice explanation Sir....

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WOW YOUR BEETER THAN academic TEACHER ... really I understand now how it development & mature thank you ^^

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[@ManishYadav-id7wl]

Sir please tell me answer I am confused so muchPositive selection in the thymus is mediated by:a Thymic epithelial cells B Macrophages C Dendritic cells D T-cells E B-cells

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Thank you

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[@harrydebarryftf8020]

This was very helpfull thank you, but I still had a question. Where does the activated T-helpercell mature into T-helpercells, T-suppressorcells and T-helper-memorycells? And where does the activated cytotoxic T-cell mature into cytotoxic T-cell and T-cytotoxic-memorycells?

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Thanks a lot shomu sir

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In this video ur smile after saying those who can bind with mhc 2 or mhc 1😂😂 was awsm😆😆

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Amazing

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Thank you

[@isha7202]

Sir after the degradation of thymus gland how's the development of the T- cells occur pls reply

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GREAT.....

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thanks a lot.

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thank you so much

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Awsm❤️

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Thank you

[@egs8545]

Can you explain what happens at eat DN stage? (DN1-DN4)?

[@aes-thete_143.]

In this first one positive and second one is negative selection??

[@clashofpubg8789]

When IL-2 is secreated by one T-cell in a peripheral lymphoid organ, do all the T-cells in the vicinity proliferate in response to IL-2 or only some of them preferentially respond to it? Explain??

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Thank you Sir

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splendid...

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You are a Savior!

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[@miabala197]

i have a doubt.... in the video he says that the thymocytes undergo apoptosis if they dont recognize the protein present on the the self cell, so how odes the thymus recognize if the thymocyte has previously bound to it or not and subject it towards apoptosis

[@kiranbheemeshwar]

exactly.

[@priyankamanuja1617]

Once they have bind to any of the receptor they are transferred to blood or lymph by venules

[@AnisurRahman-hf8mw]

You are right. If TCR receptor recognise our own antigen, those type of T cell must be destroyed.

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Thankyou sir

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+Sayena Tajdini thank you.

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Why DN cells,c-kit,cd44 are not told in this lecture?

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God bless you

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The best

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thank u

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Wow! Thank you sooooo much!!

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+Audrey Bourassa you're welcome