Testosterone Resistance - Low Androgen Sensitivity

In this video Ryan Root explains why you might need more testosterone than the average TRT dose.
0:00 intro
0:50 Causes of inter-individual variability in TRT doses/needs and levels on which one feels optimized
13:14 Environmental toxins
16:08 How to avoid environmental toxins?
17:45 Low Androgen Sensitivity: Conclusion
19:20 Typical testosterone doses
20:38 Androgen Receptor Genetics Tests
23:13 Testosterone esters
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[@TRTandHormoneOptimization]

✅ *➜Watch This Next: "Ryan Root: Total vs Free Testosterone"* kzbin.info/www/bejne/oWW0lGp6l71_eKM 💉 *➜Visit the ShopTestStore for your supplements (like Zinc, Selenium, Vitamin D3+K2 combination), 29G 1ml insulin syringes, desinfection alcohol pads, 10ml glass vials (Transfer testosterone from 1ml glass ampoules into a 10ml vial), MicroNeedling Derma Rollers, Derma Stamp, and much more at* shopteststore.co/ 📘 *➜e-book: "Acne on TRT", by Dermatologist Dr. Steven Devos MD PhD:* trtandhormoneoptimization.store/listing/acne-on-trt 📘 *➜e-book: "The Ultimate Guide to TRT Cream" Why Compounded Testosterone Cream is the BEST option for TRT, by Dr. Steven Devos MD PhD:* www.trtandhormoneoptimization.store/listing/e-book-the-ultimate-guide-to 🏋🏼 *➜Best workout split on TRT:* trtandhormoneoptimization.store/listing/workout-program-for-men-on-trt 🔶 *➜JOIN this channel to get access to perks:* kzbin.info/door/oLNk-4LAYsbfsQwjFWG2gQjoin

[@shopteststore]

Great guest!

[@mikewilliams2112]

You guys are incredible to be handing us this much information to benefit us in our TRT endeavor! Thanks so much!

[@liftingdermatologist]

Thanks for watching and commenting 🙏

[@TRTandHormoneOptimization]

Our pleasure!

[@hormonesforme]

Thank you!

[@KnockAndAskToday]

I was staggered by the amount & depth of information Ryan was providing, so thought it must be quite a short video. Then I noticed it was only 1/4 of the way through & it just kept getting better & better. Wow.

[@TRTandHormoneOptimization]

@KnockAndAskToday Thank you *so much* !

[@hormonesforme]

Thank you very much! I appreciate your support!

[@Dave_Bee]

Interesting information on the estrogen test, I’ll have to try the sensitive test next time.

[@sunshinehappyfuntimes]

You did great Ryan! That was a ton of information to put out all at once and so quickly. I think it would be good to do a series of episodes where you discuss each sub topic presented in this video separately to give ample time for the data to sink in for the viewers and give more attention to the details and include some visual aids. I would definitely watch that series. I can tell you are lifting those mental weights by covering so much at once. Impressive memory!

[@TRTandHormoneOptimization]

@sunshinehappyfuntimes , Thank *you* for watching and *commenting* !!👍

[@hormonesforme]

Thank you! You know how much I appreciate your support. I have thought about isolating these topics and providing deep dives into the individual subjects. I will keep your advice in mind. Thanks again!

[@daviddavid1057]

It was again very interesting, I really enjoyed it, thank you guys for your time and effort! 🙏🏻👍🏻

[@hormonesforme]

Thank you David!

[@liftingdermatologist]

Thanks for watching and commenting 🙏

[@TRTandHormoneOptimization]

Thank you, @daviddavid1057 , for helping to boost the algorithm!

[@scooodlescorn4070]

Man, you did great! I could feel your anxiety/nerves, but that was a sh*t ton of information. Thank you! I am treated by Royal Medical Center, but they only go as high as 200mg/week. I have to self-medicate (add test) to 255 mg to feel better. I will have to check you guys out.

[@hormonesforme]

Thank you! I assure you that we give individualized treatment and do not conform to using cookie cutter solutions. We develop a methodology to figure out what yields the best results for each individual.

[@theancientofdays9061]

Great guest!!

[@TRTandHormoneOptimization]

I appreciate that, @theancientofdays9061

[@hormonesforme]

Thank you!

[@liftingdermatologist]

100% Thanks for watching and commenting 🙏

[@ironballer1]

Hey Ryan is hormonesforme back up and running?

[@martdag1950]

Great show 👌 Steven you look in fantastic shape 👍

[@budprepper3811]

TRT +++

[@liftingdermatologist]

O thank you!

[@liftingdermatologist]

@@budprepper3811 I have video showing my protocol and blood work extensively. Watch this: kzbin.info/www/bejne/q4qyamyJeL2rY9E and this: kzbin.info/www/bejne/l5yVpGCDlrCoras

[@TRTandHormoneOptimization]

I appreciate that, @martdag1950

[@fastingfrugivore]

Excellent analysis 💯👍 On On

[@TRTandHormoneOptimization]

Much appreciated !

[@WJHandyDad]

thank you Ryan and Dr. D. Don't put everyone in a box... this is true for all healthcare.

[@liftingdermatologist]

Thanks for watching and commenting 🙏

[@TRTandHormoneOptimization]

Thank you, @WJHandyDad I appreciate that, please help by sharing this video around!

[@hormonesforme]

You are correct, this is true for all of healthcare. It is interesting that medical professionals admit that we should not treat numbers, but that is typically what is done when treating people with testosterone. This issue is the lack of understanding. When the medical community treats people with a drug they don't understand, all they have to go by is specific ranges, specific protocols, and specific doses - the box of which we speak.

[@user-ej5sk4cq2d]

@@hormonesforme that's because they are governed by their medical boards and there are consequences if sanctioned by them...loss of license for instance. Something you don't understand since you have zero medical training

[@malekmalek9064]

👍goei zondag nog Makker

[@liftingdermatologist]

Dank je! Fijne zondag yourself!

[@TRTandHormoneOptimization]

Thank you, @malekmalek9064 , for helping to boost the algorithm!

[@UranusfromBrussels]

Great video. Personally 125mg per week takes me above the reference range on total and twice as high on free testosterone. Really depends on genetics and finding your “sweet spot”

[@TRTandHormoneOptimization]

Well said!

[@Mikaeel84]

I need 360mg a week to be at the top of the reference range.

[@harryjohnson370]

What's your dosage protocol?

[@Mikaeel84]

@@harryjohnson370 I've gone all the way from dividing it up into 4 times a week, all the way to every day. My doctor says it's because I lift and work industrial construction for 12 plus hours a day sometimes 7 days a week. He said the more active you are the more you burn through it. I also weigh 217lbs at about 20% bf yet surprisingly I perfectly convert estradiol to top of the reference range also. Also I use the ultra sensitive testing for more accurate readings. I have also tried two different compounding pharmacies here in America and got the same results with both enanthate and cypionate.

[@hormonesforme]

This anecdotal evidence is important. I have seen this before. Thanks for sharing.

[@DOOR.DASH.TYRONE]

Did you find a doctor that was willing to prescribe this dosage or did you have to self medicate? I assume some doctors wouldn't give that much no matter what because they are under the belief that 200mg a week should be the highest dosage they prescribe.

[@Mikaeel84]

@@DOOR.DASH.TYRONE I go through Matrix Hormones who is telemedicine in the USA. They started me at 125mg a week and slowly worked me up. I have exhibited exceptional blood work throughout the process and was told if that wasn't the case they wouldn't be able to do it.

[@simonm1135]

How high of a total and free testosterone level is considered safe long term? Would low androgen sensitivity make you neesd a higher dose of T to feel optimal no matter the level? Say if you were on 300mg and your levels are 2500 TT and 75 FT? This isnt my situation but I am curious.

[@darrinuhl8103]

Hi. I no longer have access to the Facebook group. Not sure but maybe I was blocked? Could someone reinstate me?

[@HVS23]

I went from 200mg a week with side effects to 92mg a week without side effects and everything feels awesome. Mentally, physically and emotionally . I guess they started me to high from the get go and thats is a mistake.

[@bm2618]

What’s your dosing protocol, once a week, twice a week, daily?

[@MartinTeerly]

Can your body get "tired" of certain manufacturer or even estr of testosterone?

[@ronmexico79]

Good question..

[@mikea1534]

I did 100 weekly an I felt ok but my total 1588, dr wants me to go down to 80 to see if I feel better, however I’m naturally skinny and hard gainer and I’ve been more active now an I’m stuck at 140lbs, wtf is wrong with my body, I did 200 for a few weeks and felt pretty good. If my total is over 2000 think it’s unhealthy or should I just be concerned with estrogen lvl an hemtaceit

[@hormonesforme]

Great question. There is no reason to lower your dose from 100mg per week to 80mg per week just because of a 1588ng/dL total T level. If you feel better at 100mg per week, or even a little higher, then it is likely a good dose for you. Your H and H may read as slightly elevated; even at 53-54%, that is fine. People who take testosterone will have increased red blood cells, and that is beneficial. It does not increase clotting factors such thrombin, prothrombin, or platelets, so clotting is not an issue. Many people are afraid of some unknown silent killer from elevated blood testosterone levels, but, over 80 years of people taking exogenous testosterone, there are no silent killers. If your dose is going to cause long term health concerns, it will manifest in your health markers. Your estradiol level, if it is not causing adverse side effects, is not a concern, and slightly elevated H and H is not a concern. If you are a very skinny guy with a very low frequency of androgen receptors, you may need a circulating blood testosterone level of 2000 to feel like most people do at 1000. Don’t focus on the numbers, focus on symptom resolution.

[@mikea1534]

@@hormonesforme well my estrogen was a little high but I didn’t feel terrible. Honestly I might tell the the clinic I need to up the dose. Yeah I’m a small dude. And I havnt gained any weight over the past 2 months and im active . Idk bro

[@kgf2603]

With that said, is there any way to increase androgen sensitivity? Or is the workaround simply to add more testosterone and deal with side effects? What do your TRT+++++ clients do with RBC and Hematocrit when they're blasting 400 mg weekly?

[@benbarker7311]

l carnitine has been shown to have some androgen receptor upregulation properties

[@TRTandHormoneOptimization]

I am sure Ryan will answer this soon.

[@hormonesforme]

Great Question. There is some studies indicating that L-Carnitine can increase androgen receptors. The empirical and anecdotal date suggests, as with all amino acids, if your body is deficient in a certian amino acid, then supplementing with that amino acid can help. However, L-Carnitine is not an essential amino acid, and most people obtain the nutrients in their diet to synthesize enough L-Carnitine, and adding L-Carnitine to an already adequate amount of L-Carnitine does not increase the output of L-Carnitine functions. In my last video with Dr. Devos, which is linked above, I dive into SHBG and how that can increase your frequency of androgen receptors and binding affinity of testosterone to the androgen receptors; indicating that an adequate level of SHBG is important to androgen sensitivity. If low androgen sensitivity is due to genetic predispositions or environmental toxins, we currently don't really have a way to deal with that, and in those cases, pushing testosterone through the obstacles is an effective way to overcome that type of low androgen sensitivity.

[@hormonesforme]

To answer you question about elevated Hematocrit and high testosterone doses; my clients that require high doses likely have low androgen sensitivity, and the binding of testosterone to the androgen receptor is obstructed. Testosterone only has its cascade of effects once it binds to the androgen receptor. If the androgen receptors are obstructed, high doses only beget an average frequency of binding to the androgen receptor, and their hematocrit does not get too elevated. I don't like theraputic phlebotomy, because it adversely effects ferritin and iron in the blood, but occasionally it may be necessary.

[@DanielPekic]

Most guys on 400 mg a week have the same issues as those on TRT. Elevated HCT to dangerous levels isn’t a guaranteed thing even for AAS users. Do more cardio. That works 100% of the time. Think cyclists and EPO. They’d kill to have those lazy man numbers.

[@fallenace99]

Overall, this guy seems to really know his stuff, and I learned a lot from this. However, I looked up the thing about Sigourney Weaver being born an XY male with complete androgen insensitivity syndrome, but it seems to be a myth. She gave birth to a child in 1990.

[@hormonesforme]

Interesting… thanks for clarifying. I did not look into this deeply, so it very well could be a myth. My apologies to Sigourney Weaver.

[@narmypara100]

I take 400 a week ive juiced since i was 18 im now 50 obvs on and off in younger years been on perminent 12 years

[@hormonesforme]

Those of us that have been bodybuilders, or are experienced with AAS, typically need higher doses of testosterone to feel normal or adequate. My clinic treats many ex bodybuilders that require higher than average doses. Thanks for sharing your anecdotal evidence. It is important to hear.

[@liftingdermatologist]

👍Thanks for watching and sharing 🙏

[@TRTandHormoneOptimization]

@narmypara100 Thank you for sharing!

[@Hash1985]

​@hormonesforme with ex bodybuilders what levels are seeing... total T Free ... etc and amount of test to get that level? Thank you

[@simonm1135]

​@@Hash1985I would love to know that as well. I know everyone's different but an idea would be nice.

[@joengkampman1987]

I need a 1000 mg and some deca😅

[@rickycarfan54]

wow… this is a very interesting topic. i think i’m one of those people with the lower andrgen sensitivity in the world. i said do cause i want from my natural 150/180ng/dL to my actual 1750mg per week (meaning 250mg test per day), with test blood level trought the roof (the test just report: over 3500nd/dL) but honestly do not feel any difference in my physical performance, on strenght, on energy… an even less on my mind: attitude, motivation, anxiety, determination… 🤷‍♂️ 🤷‍♂️ then.. does it exist a way to increase or improve their androgen sensitivity??

[@liftingdermatologist]

Thanks for watching and sharing! 🙏

[@TRTandHormoneOptimization]

Thank you, @rickycarfan54 , for helping to boost the algorithm!

[@hormonesforme]

Great Question. This is intersting anecdotal data. It is possible, in your case, there is something more causing your lack of symptom resolution. It is possible that your androgen sensitivity is low to the point that you are being unaffected by testosterone. I don't have enough data to understand. Tpo answer your question, There is some studies indicating that L-Carnitine can increase androgen receptors. The empirical and anecdotal date suggests, as with all amino acids, if your body is deficient in a certian amino acid, then supplementing with that amino acid can help. However, L-Carnitine is not an essential amino acid, and most people obtain the nutrients in their diet to synthesize enough L-Carnitine, and adding L-Carnitine to an already adequate amount of L-Carnitine does not increase the output of L-Carnitine functions. In my last video with Dr. Devos, which is linked above, I dive into SHBG and how that can increase your frequency of androgen receptors and binding affinity of testosterone to the androgen receptors; indicating that an adequate level of SHBG is important to androgen sensitivity. If low androgen sensitivity is due to genetic predispositions or environmental toxins, we currently don't really have a way to deal with that, and in those cases, pushing testosterone through the obstacles is an effective way to overcome that type of low androgen sensitivity.

[@rickycarfan54]

i have also low shbg! maybe that affect my sensotivity too! what is good is tuat right now even at this super high doses i seem not to have any side effect. Absolutely nothing from the prospective of anxiety, nervousness, weel being, acne, gyno… but also my blood level are ok: lipid panel, blood pressure, ematocrit… everything seems in place.. 🤷‍♂️ it’s really really strange!!!

[@hormonesforme]

@@rickycarfan54 Yes! Low SHBG will adversely affect your sensitivity to testosterone. I have many clients with low SHBG and high free testosterone that begin to feel symptoms of hypogonadism again because their our bodies, to protect us against elevated hormones, will desensitize us to testosterone if there is not enough SHBG present.

[@Mikaeel84]

This guy needs to take speech classes if he plans on doing this more.

[@hormonesforme]

Yes, I do get nervous on camera speaking in a punctuated and choppy manner. Sorry about that.

[@Mikaeel84]

@@hormonesforme no reason to be sorry man. You'll get better.👍👍

[@harryjohnson370]

@@hormonesforme oh don't apologize to the peanut gallery brother. Those of us that only care about knowledge and facts thank you greatly, becaue we actually learned something from you. It be great to see you back on this channel and hear more about outliers that we never hear about on the forums. I'm one of them, an ex bodybuilder completely destroyed by a decade of exemestane use. I have to take estradiol enanthate with my test now. Valerate doesn't last the entire day in me. The more test I take, the more estradiol I need. It's like I don't aromatize at all anymore. Last blood test I took before supplementing estrogen I was at 7. I have ZERO erections and libido without estrogen. Ever hear of this at your clinic doc?

[@hormonesforme]

@@Mikaeel84thanks you!

[@umairiqbal8323]

​@hormonesforme in our multicultural world, we are more accustomed to grasping different accents. You are absolutely fine your message is properly delivered. Some people need to work on their hearing therapy I guess.

[@user-ej5sk4cq2d]

Ryan is obviously several years behind in that you have had multiple MDs and others already discuss these very topics. Ryan is not a medical provider right ? He is just another clinic owner who pays a provider to treat. Who is the provider his clinic uses? Why is it not mentioned on his website? Ryan CAN'T TREAT!