These 14 Medications are linked to lower death rates in humans | 23 - Longevity this Week #4

[@lucycooper55]

Incredible information. Thank you

[@Norm475]

I've been retired for about 30 years, and when I was working I sold statins. At that time statins were shown to decrease heart attacks and stroke however, all-cause mortality was not reduced, and actually suicides increased in the statin group.

[@espinosalexis]

Aren't SGLT2 inhibitors just treating metabolic syndrome due to damaging diet? Rather than really treating the aging biology? It's surprising that many anti-diabetes drugs show positive effects in the ITP. I think the ITP project is flawed. Mice chow and ad-libitum intake is inducing metabolic syndrome in the mice. ITP project should invest a year of resources in defining a whole natural food diet and optimal quantity so that drugs can be tested vs a proper control group not damaged by their diet and the amount of food.

[@ryan_the_red_4907]

Especially awesome episode, lots of info i haven’t seen elsewhere very directly addressing longevity pharmacology. Please keep this up!

[@chunglau266]

Thanks so much for doing your podcast. Im grateful to get longevity info from a scientist who isn't peddling snake oil. Please always disclose your sponsors like delaurer and attia

[@michaelmcmullen354]

The Kaiser health systems and the VA in the US have good digital records going far back.

[@peterz53]

Mechanism matters. And your own health status. Atorvastatin for example. I recall one study in JAMA from years ago which indicated a major mechanism for why statins worked was reduction in inflammation, more so than impact on LDL. And we know that inflammation has broad negative health effects. But I would not take a statin for that reason as my hsCRP is chronically low, 0.3 or less. It may that a number of drugs, NSAIDS for example, work simply by lower inflammation.

[@greggluberto167]

Statins may reduce the risk of HA or stroke but they increase the risk of arteriosclerosis.

[@AndrewOudin]

Dexamethasone is a glucocorticoid, not an NSAID.

[@cactuscanine3531]

A SAID, not an NSAID.

[@AndrewOudin]

well Said 😎

[@bornatona3954]

He said nsaid and you can read on screen

[@bornatona3954]

He also said neomycin is tetracycline It is basic med school Unbelievable

[@CB12359]

@@bornatona3954 He's not an M.D., so maybe cut him some slack.

[@danmarquez3971]

Very interesting. I still have no plan to run to the pharmacy and adding any of the meds to my diet. LOL! However, the estrogen benefits may suggest taking a closer look at the benefits of yam and soy consumption. The PDE5 inhibitors may suggest taking a closer look at nuts, grains, seeds, and legumes. I believe evidence already exists that all these plant-based foods can increase life expectancy. Googling does list a plethora of interesting articles... too many to sort through. Ugh! (But I won't believe that red meat and processed meat increases life expectancy because of the convincing evidence I previously read.)

[@AndrewOudin]

A number of narrow- and broad-spectrum PDE inhibitors seem to show promise as strategic antiinflamatory agents. I wonder if TLR4 might emerge as a common target. Great video, thanks for the hard work.

[@ProgrammeringPC]

Good information but way too much detail and repetition. This could have taken half the time.

[@viracocha2021]

Super interesting! Thanks for the deep dive. Also interesting that the two more important mechanism are shared with mice data in the ITP.

[@cactuscanine3531]

A preprint of an association study must be questioned until further verified. Nevertheless, a great video with thorough explanation.

[@MisterProducts]

Can you do a video on SSRIs benefits vs cons? For e.g. potential osteoporosis

[@faustopacheco120]

doesn't atorvastatin correlate with higher dementia rates?

[@Zanthous_]

Something else good to come from this study is finding what drugs appear to be safe to take when you have existing issues, for example naproxen you can tell seems like a reasonable choice now. I'm going to take a look at the other end of the spectrum too just in case to see what could potentially be harmful (keeping in mind the drawbacks noted by authors)

[@Dr.AmyBKillen]

This makes total sense to me. Estrogen is very metabolically active, reducing visceral fat and insulin resistance. It also improves lipids (HDL, LDL, ApoB, Lpa), and is anti-inflammatory. Synthetic Estrogen+ progestin got everyone confused but if you look at bioidentical Estradiol and Estriol it's all positive data.

[@gemagel20]

After thanking Dr Matt, who is a very reliable source, for the valuable info I would like to pose a difficult question. Dr Amy you seem to be an expert on hrt for women. What a woman diagnosed with early stage breast cancer hormone positive that had it removed (that followed the full preventive therapy, radio, chemo, surgery) but has to follow an hormone therapy for a lot of years should do? Is there any estrogen that she could take that doesn't increase the risk of cancer? She is 46 and healthy now after 3 years of hormone therapy. I believe there a lot of women like her that do not know what to do to get the benefits of estrogens.

[@chuckding5590]

Doxycyclin inhibits MMP9 degradation at pharmacologically-achievable concentrations. There is a literature on its use in models of neurodegeneration and brain trauma. In particular, there was a high quality report in about 2021 of a mouse model of AD that showed this antibiotic (as well as urolithin A) helped maintain BBB integrity resulting improved cognitive function and memory. Neither molecule were in the report title, so I couldn't find the report by a quick search.

[@Travelbythought]

I think the 17A estradiol is very interesting. Someone needs to make it more available.

[@salobaid9652]

Good review Matt. The surprising findings Of this review is the unexpected benefit of estrogen on reducing mortality.I will be cautious in interpretation of these data.As a practicing physician for many years I don't prescribe estrogen to high risk women.We know the risk of vascular events from estrogen and it's effects on clotting mechanism.I always avoid estrogen in patients who have any vascular disease including diabetes and any one with clotting history or at increased risk for thromboembolic disease.That is why women who receive estrogen are healthier with higher socioeconomic status and this is likely the explanation for estrogen benefits.I council my patients and tell them that estrogen harm high risk individuals and can help healthy low risk patients.

[@audreyhurley6248]

What about estrogen HRT benefits in mature women, we’re there any older women in the research study? If so what were their results? Thanks, love these videos!

[@bornatona3954]

Doc ,dexamethasone isn't nsaid and neomycin isnt tetracycline

[@newyorkskier]

Hello Matt: Very informative and scientific show. I have one question. Would taking rapamycin affect your ability to build skeletal muscles?

[@PrometheusLux]

Could the Estriol and Estradiol effect come from LH/FSH suppression? Especially FSH is rising sharply with aging and is associated with occurrence of diseases like sarcopenia, obesity, frailty syndrome, cardiovascular disease, cancer and osteoporosis. Could they be pro-aging factors?

[@5kribbles]

Is it possible the positive association with all of the Estrogens is just that women receiving that are during menopause are already more in contact with their healthcare providers, have more money, and have more personalised care and frequent follow ups. Most women don't seek hormone replacement during menopause and those that do would definitely be more active and have the means managing their health to a greater degree.

[@chunglau266]

I know I probably shouldnt supplement with Naproxen but should I buy some for occasional headaches? Should i buy mechlazine for occasional motion sickness?

[@bill9989]

Not meclizine. It is an anticholinergic drug that can increase the risk of dementia in older adults. It was recently found to be an mtor inhibitor but at what cost? No thanks.

[@bill9989]

For some strange reason, YT (I don't think it's Matt) won't let me advise anyone about the 2nd drug you mentioned. Search that drug and dementia. P.S. you misspelled it. Search the correct spelling and dementia.

[@SilverFan21k]

Congrats on near 5k subscribers

[@neilquinn]

Any difference between low dose (83mg) aspirin vs. regular aspirin?

[@salobaid9652]

Aspirin affect on clotting is not dose related. For prevention of heart attacks and stroke we use 81 mg which has the d same effect as 325 mg.Lower dose is safer.using aspirin for pain requires the regular dosing.

[@workingTchr]

Tetanus and Hep-A vaccination here I come. Man, if I was going through menopause I'd definitely be getting one or more of these for that.

[@medicallyenhanced]

i LOVE your channel.

[@Norm475]

Naproxen has been shown to cause a decrease in kidney function with long-term use.

[@metemad]

Thank you.

[@Char_603]

Tadalafil versus ssildenafil. Does one have more side effects OR more benefit?

[@kamanashisroy]

Tdap was a bias Matt. Wealthy people born British, have more access to Tdap. People that did not take TDAP, have less access to healthcare.

[@johnhemming]

If the levels of cytosolic acetyl-CoA are on the key aging pathway then statins will directly affect this even if only in a limited manner.

[@paulfiedler9128]

What would you consider to be an effective low dose of Tadalafil? Thanks

[@greggluberto167]

None it causes palpitations

[@drumsnmore2545]

2.5 mg/day is the lowest Rx dose

[@krisvette5874]

Serious signal worth investigating.

[@TheKeats06]

Was there any data shown on progesterone?

[@mystrength5640]

Previously, Progesterone alone, Was Said to increase Diabetes. After aged 50! So Oestrogen alone was prescribed! Will be interesting to hear, new Outcomes!

[@TheKitty1952]

Dexamethasone is a steriod...not an NSAID.

[@christopherbrand5360]

Wouldn't Otomize prescription be an effective way of identifying individuals who swim? Any prescription that is used to treat the effects of exercise would be expected to be associated with individuals who are healthier than the general population.

[@anode-cathode]

One correction: dexamethisone is a steroid, not an nsaid.

[@medicallyenhanced]

dexamethasone is a corticosteroid

[@joeextraknow2854]

Can some summarize if watched all?

[@PerMattson]

The big winners here are the estrogens, which are associated with a reduction in all-cause mortality by 20% or more. But there have been extensive studies of estrogens (such as the Women's Health Initiative) which showed equivocal or even negative health impacts for estrogen replacement. How do we reconcile the current analysis with those studies? Is it really possible that estrogen replacement therapy raises the risk of breast cancer and heart disease (albeit minimally) but simultaneously reduces all-cause mortality by 20% or more? And if we can't make sense of this, do we really trust this analysis for the other drugs, for which (in most cases) there are no such studies?

[@elst2504]

I would strongly advise to check this book “Oestrogen Matters” from dr Avrum Bluming and Carol Travis PhD! Thank Mat, very interesting!!

[@MsElaine122]

The WHI study has been discredited in its false results of generalized assertion that BHRT avoids and thus are beneficial. Google for the discretiting studies.

[@Dr.AmyBKillen]

When given early in menopause and without synthetic progestins, estrogen reduced breast cancer and CV disease in the WHI. Multiple large observational studies and several RCTs have shown us that bioidentical Estradiol and Progesterone are much better than the WHI at reducing cancer, CV disease, and dementia risks and they don't carry the same risks that were seen in the progestin arm of the WHI.

[@sgill4833]

50 mg sildenafil makes you drowsy and sleepy., but messes up your vision.

[@Milpower]

:/ Check your spelling.

[@KenDanielMurphy]

Anyone else have the compulsion to repeat the word conagloflosen everytime he said it? Just me? Ok. 👀

[@notrueflagshere198]

"Broad" benefits for women?

[@nadernayo]

👏👏

[@dianaboos5602]

I thought statins increased the risk of dementia?

[@Nilsosmar]

Three thoughts: 1) Some studies suggest they do; other studies came to a different conclusion 2) What's true of one statin may not be of another. 3) Matt is suggesting in the video that a small dose of one particular statin "may" reduce all cause mortality (but it's also possible that it may not)

[@bill9989]

This is a concern. If a particular statin has a positive effect on lifespan but contributes to dementia, then it is an overall negative. The last thing I want is to be long living with dementia.

[@hadleys.4869]

From the research I've seen, they do not cause dementia.

[@natureins4644]

@@bill9989 There is no way you are going to live long with dementia. Even if the risk of getting dementia may (or may not) be increased with statins it is far outweighed by the benefit of postponing dying from cardiovascular disease.

[@abdelilahbenahmed4350]

@@bill9989 ha ha ha

[@67daltonknox]

Hope the statin bashers are watching.

[@doctormurphy]

Pooled data unimpressive

[@harveyquirke6376]

The. Secret. To. Long. Life. Is. Don't. Pick. Up. Cigarette. Butts

[@len5742]

Your intro music is ridiculous. Instead of talking to a camera nonstop, write a blog post. Save all of us an immense amount of time. Either that, or hire Physionic read the script.

[@jowarren4083]

Picky like a pick ax.

[@user-ln3vw5mo7n]

Statins reduce the risk of Alzheimer's disease by 38%, (also vascular dementia). Theses diseases are not observed in mice.

[@evanmoyle]

Estrogen, the deeper reason women outlive men on avg?

[@Norm475]

I've read that when you adjust for accidents, homicides, and smoking, men live as long as women, and the gap is narrowing as more women smoke, and more men are quitting. In my group of friends and relatives, the men have been outliving their wives or X wives by at least 2 to 1.

[@user-ln3vw5mo7n]

Women live longer than men, so the estrogen effect may be the cause.

[@johnnykrauze]

Or Iron.